METASTATIC MELANOMA

This early-stage trial tested a drug called STI-3031, given directly into lymph nodes or vessels using a special device, for people with in-transit melanoma (skin cancer that has spread along lymph channels). The goal was to find a safe dose and check for side effects. Only 3 peo…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in adults with melanoma or kidney cancer that had spread to the brain. Participants had already received anti-PD-1/PD-L1 treatments. The goal was to see if the drug combo could shrink brain tumors. The st…

This early-phase trial tested a specially modified virus (VSV-IFNb-TYRP1) in 12 people with advanced melanoma that had spread or couldn't be removed. The virus was injected directly into tumors and into a vein to see if it could safely trigger the immune system to attack cancer c…

This study looked at two ways to treat cancer that has spread to the brain and returned after initial radiation. One method used focused radiation only on the new tumors, while the other used whole-brain radiation while trying to protect memory areas and adding a medication to re…

This study tested a treatment that takes immune cells from a patient's own tumor, grows them in a lab, and gives them back to fight cancer. It included 225 adults with advanced melanoma, head and neck, or lung cancer. The goal was to see if these cells could shrink tumors and how…

This study tested a new drug called PF-08046031 in 11 adults with advanced melanoma or other solid tumors that had spread or had no standard treatment. The goal was to check the drug's safety and side effects. The study was stopped early, so results are limited.

This study tested a new drug combination for people with advanced melanoma that cannot be removed by surgery or has spread. The experimental treatment involved injecting CMP-001 directly into tumors along with the immunotherapy nivolumab, compared to nivolumab alone. The study wa…

This study tested two drugs, bintrafusp alfa and pimasertib, in people whose cancer had spread to the brain. The goal was to find the best dose and see if the combination could slow or stop tumor growth. The trial was stopped early after enrolling only 8 participants, so no clear…

This early-stage trial aimed to see if adding a device that sends gentle electric fields (tumor treating fields) to standard radiation and immunotherapy could help people with melanoma that spread to the brain. Only one person took part before the study was stopped early. The mai…