MALIGNANT DIGESTIVE SYSTEM NEOPLASM

This study is testing whether a new dosing guide called PAGODA can help prevent unplanned delays during FOLFOX chemotherapy for cancers of the digestive system. About 420 adults with GI cancers will be randomly assigned to either standard care or the PAGODA-guided dosing. The goa…

This study tracks 150 gastrointestinal cancer patients with a narrowed portal vein who receive a stent to keep the vein open. Researchers will monitor how long the stent stays clear, changes in liver function, nutrition, bleeding risk, and quality of life. The goal is to see if s…

This phase I/II trial tests whether vasodilator drugs (isosorbide mononitrate or diltiazem) can prevent blood vessel damage caused by fluoropyrimidine chemotherapy in 60 patients with gastrointestinal cancer. Researchers will monitor blood vessel reactivity using a non-invasive d…

This study tests whether fucoidan, a supplement from brown seaweed, can reduce fatigue caused by chemotherapy in people with gastrointestinal or gynecological cancer. About 34 participants will receive either fucoidan or a placebo, and report their fatigue levels over 16 weeks. T…

This study tests whether giving the chemotherapy drug oxaliplatin over 6 hours instead of the usual 2 hours can prevent or delay nerve damage in people with gastrointestinal cancers. About 60 participants will be randomly assigned to one of two infusion times. The goal is to see …

This study is collecting tissue and blood samples, along with questionnaires, from 1,500 people with biliary tree cancers and healthy volunteers. Researchers hope to identify risk factors and genetic changes that influence how these cancers develop and respond to treatment. The g…

This study gathers information on side effects from proton therapy in 5,000 adults with various cancers. Researchers will collect details on treatment plans and any short- or long-term side effects. The goal is to better predict who might have side effects and improve future care…

This study surveys 500 surgeons and advanced practice providers to see how often they prescribe blood clot prevention medication after abdominal or pelvic cancer surgery. The goal is to understand current practices and improve adherence to guidelines. No patients are treated dire…