LYMPHEDEMA

This study is testing a robotic system called Symani to help surgeons perform very delicate microsurgery, such as reconnecting tiny blood vessels during tissue transfer or treating lymphedema (chronic swelling). About 180 adults who need these procedures will take part. The goal …

This study is testing a surgical robot called Symani to help surgeons perform very delicate microsurgery, such as reconnecting tiny blood vessels during tissue transfer or treating lymphedema (swelling). About 455 adults will take part, and researchers will check if the robot wor…

This study tests whether a ketogenic diet (low-carb, high-fat) can improve lymph vessel function and reduce swelling in people with arm lymphedema after lymph node removal. Participants will be randomly assigned to a ketogenic diet or a standard diet, with or without a ketone sup…

This study tests whether two different drug combinations—pentoxifylline with vitamin E, or pravastatin alone—can prevent or reduce lymphedema (swelling) and fibrosis (scarring) caused by radiation therapy for head and neck cancer. About 295 adults who are about to receive radiati…

This study tests if adding medication can treat or prevent lymphedema and fibrosis—painful swelling and scarring—caused by radiation therapy in head and neck cancer survivors. About 250 participants who have finished radiation at least 6 months ago will receive one of several dru…

This study tests if a special program can prevent lymphedema (arm swelling) in women having lymph node removal for breast cancer. About 285 women will be followed for at least a year to see if the program reduces swelling and improves quality of life. The goal is to find a better…

This study uses different ultrasound techniques to find clear differences between lymphedema and lipedema, two chronic conditions that cause leg swelling and are often hard to tell apart. Researchers will compare tissue thickness, stiffness, and other features in 75 people (25 wi…

This study tests if repairing the lymphatic system right during lymph node removal surgery can lower the chance of developing lymphedema, a painful arm swelling. About 50 women with breast cancer will get this extra reconstruction step. The goal is to see if more women stay free …

This study tests a low-risk surgical procedure called LYMPHA, done at the same time as breast cancer lymph node removal, to prevent lymphedema—a chronic, painful arm swelling. About 80 adults undergoing breast cancer surgery will be randomly assigned to receive LYMPHA or standard…

This study looks at whether adding aerobic exercise to standard lymphedema therapy can help people with swelling in both legs walk better, keep their balance, and build leg strength. Researchers will compare two groups: one doing aerobic training plus standard care, and another r…

This study tests if progressive resistance exercise can improve arm swelling and function in people who developed lymphedema after breast cancer treatment. Fifty adults aged 18-60 who are at least 3 months post-surgery will be enrolled. Participants will do supervised exercises, …

This study looks at whether doing resistance exercises (like leg presses) can reduce swelling in the lower legs of people with lymphedema. It also checks if wearing compression garments during exercise makes a difference. About 36 adults with lower limb lymphedema will take part,…

This study tests whether adding virtual reality (VR) exercises to standard therapy can improve walking, daily function, and quality of life in people with lower leg lymphedema (chronic swelling). Forty adults with stage 2 or 3 lymphedema will use a VR treadmill system alongside t…

This study tests a lightweight, portable compression device for people with leg swelling caused by lymphedema or chronic vein problems. About 100 adults will use the device at home to see if it reduces swelling, improves walking, and lowers healthcare costs compared to older trea…

This study tests two non-invasive therapies—extracorporeal shock wave therapy and pulsed electromagnetic field therapy—for people with lymphedema after breast or gynecologic cancer. Lymphedema causes painful limb swelling that makes daily tasks hard. The goal is to see if these t…

This study follows 1,250 women who have had lymph nodes removed during breast cancer surgery to see how many develop lymphedema (arm swelling). Researchers will look at breast tissue for signs of inflammation that might raise risk, and ask participants about their quality of life…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to look for biological markers that could help understand these conditions better. The goal is to support…

This study follows 10,000 breast cancer patients to detect arm swelling (lymphedema) early after treatment. Researchers use arm measurements and patient surveys to understand how swelling affects daily life and quality of life. The goal is to improve screening and outcomes by cat…

This study is checking if people with lymphedema (a condition causing arm or leg swelling) have higher levels of a blood fat called lipoprotein(a), which is linked to heart attacks and strokes. Researchers will test 100 adults with lymphedema to see how common high LP(a) is and h…

This study aims to understand why lymphedema happens by comparing gene activity in swollen versus healthy limbs. Researchers will analyze tissue samples from 60 adults with either inherited or cancer-related lymphedema. The goal is to identify key genes involved, which could lead…

This study follows 100 women with early-stage breast cancer for two years after surgery and other treatments. Researchers will measure changes in muscle mass and body fat to understand how the body recovers. The goal is to learn more about long-term health and quality of life aft…

This study looks at how lymphedema patients' quality of life changes over time, comparing those who choose surgery (a lymph node transfer) with those who choose non-surgical care. Researchers will follow 600 adults aged 18 to 80 with arm or leg swelling. The goal is to understand…