LUNG NON-SMALL CELL CARCINOMA

This study tests whether a cancer drug called atezolizumab can be given safely at home to people with non-small cell lung cancer. Instead of going to a clinic, patients receive the injection under the skin from a nurse while using telemedicine. The goal is to see if this home-bas…

This study is for people with stage II or III non-small cell lung cancer who are not healthy enough for standard treatments. It tests a shorter, stronger radiation course followed by the immunotherapy drug atezolizumab. The goal is to see if this combination is safe and helps con…

This study looks at whether adding radiation therapy to standard immunotherapy (with or without chemotherapy) can help people with advanced non-small cell lung cancer that lacks the PD-L1 marker. About 427 adults with stage IIIB, IIIC, or IV disease will be randomly assigned to r…

This study compares two medications, infliximab and vedolizumab, for treating colitis (colon inflammation) caused by immune checkpoint inhibitor cancer therapy. About 47 adults with genitourinary cancer, melanoma, or non-small cell lung cancer who develop moderate to severe diarr…

This study tests whether adding the immunotherapy drug atezolizumab to standard radiation therapy helps people with early-stage non-small cell lung cancer live longer. About 480 high-risk patients will receive either radiation alone or radiation plus atezolizumab. The goal is to …

This phase III trial tests whether adding the drug AZD6738 to the immunotherapy durvalumab can help prevent lung cancer from returning after chemotherapy and surgery. About 630 adults with stage II to IIIB non-small cell lung cancer will be randomly assigned to receive either the…

This study tests a vaccine called CIMAvax combined with immunotherapy drugs (nivolumab or pembrolizumab) in people with advanced non-small cell lung cancer or head/neck cancer that has spread. The goal is to find the best dose and see if the combination helps control tumor growth…

This early trial tests whether adding surgery or radiation to the targeted drug brigatinib can better control advanced ALK-positive non-small cell lung cancer. About 35 people whose cancer has spread or returned will receive both treatments. The main goal is to check safety and s…

This study compares giving the immunotherapy drug pembrolizumab every 12 weeks versus every 3 weeks for people with non-small cell lung cancer who are already benefiting from the drug. The goal is to see if the less frequent schedule works just as well, which could mean fewer hos…

This early-phase trial tests whether adding papaverine (a drug that relaxes blood vessels) to precise, high-dose radiation therapy is safe and helps control non-small cell lung cancer or lung tumors that have spread from other cancers. About 19 adults with tumors 5 cm or smaller …

This study looks at whether adding surgery or radiation to the targeted drug osimertinib helps people with advanced EGFR-mutant lung cancer live longer without their cancer growing. About 173 adults with stage IIIB or IV non-small cell lung cancer that has a specific EGFR mutatio…

This study tests a DNA vaccine called STEMVAC in people with stage IV non-small cell lung cancer. The vaccine helps the immune system recognize and attack cancer cells. It is given alongside standard maintenance therapy. The goal is to see if it can shrink tumors and improve outc…

This early-phase trial is testing whether combining two immunotherapy drugs (ipilimumab and nivolumab) with radiation therapy is safe and effective for people with stage II or III non-small cell lung cancer that cannot be removed by surgery. The goal is to see if this approach ca…

This study compares two treatments for lung tumors: microwave ablation (using heat to kill cancer cells) and surgical wedge resection (removing a small piece of lung). It includes people with early or advanced lung cancer, sarcoma, or colorectal cancer that has spread to the lung…

This study tests a drug called AMG 510 in people with advanced lung cancer that has a specific genetic change (KRAS G12C mutation). The drug is designed to block the cancer's growth signal. About 116 participants will receive the treatment to see if it shrinks tumors and how safe…

This study tests whether adding local treatments like surgery or radiation to a two-drug immunotherapy regimen helps people with stage IV non-small cell lung cancer live longer. About 339 participants will receive either immunotherapy alone or immunotherapy plus local therapy. Th…

This study looks at whether giving a single, precise dose of radiation after lung cancer surgery is safe and causes fewer side effects than the usual weeks-long radiation. About 50 adults with non-small cell lung cancer who had surgery but still have cancer cells at the edge of t…

This study looks at whether a drug called anamorelin can help improve appetite and stop weight loss in people with advanced non-small cell lung cancer who have lost their appetite and weight. About 25 participants will take either the drug or a placebo and share their experiences…

This study looks for early signs of heart injury in people receiving radiation therapy for lung or esophageal cancer. Researchers use heart scans and blood tests to detect changes during or shortly after treatment. The goal is to identify patients at risk for heart problems and i…

This study looks at over 1,300 cancer patients to find out who is more likely to develop nerve damage (tingling or numbness in hands and feet) from taxane chemotherapy. Researchers will track factors like age, gender, and pre-existing conditions to create a prediction tool. The g…

This study tests a decision aid designed for people with non-small cell lung cancer. The tool helps patients and doctors talk together about treatment options, risks, and what matters most to the patient. About 98 adults with lung cancer will use the tool to see if it improves th…

This study tests a telehealth self-management program for people who have finished treatment for early-stage lung or colorectal cancer. The program coaches survivors on follow-up care, communication with doctors, and managing their health. Researchers want to see if it improves c…

This study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. The goal is to track how cancer changes over time and during treatment. Researchers hope this will help them understand why some cancers resist therapy a…