LUNG NON-SMALL CELL CARCINOMA

This early-stage trial tests the safety and best dose of gilteritinib, a drug already approved for leukemia, in 30 people with stage IV ALK-positive non-small cell lung cancer whose tumors stopped responding to other treatments. The goal is to see if the drug can control the canc…

This study tests a combination of two drugs, telisotuzumab vedotin and osimertinib, in people with a type of advanced lung cancer (non-small cell lung cancer) that has stopped responding to osimertinib alone. The cancer must have a specific gene change (EGFR mutation) and a high …

This study tests whether using a PET scan to guide radiation therapy can better control lung cancer, melanoma, or kidney cancer that has started growing again in up to 5 spots. About 32 adults will receive either standard radiation or a PET-adapted version that delivers a higher …

This early-phase study tests whether adding low-dose IL-2 to the immunotherapy drug pembrolizumab can strengthen the immune system's attack on advanced lung cancer. About 15 people with untreated stage IV non-small cell lung cancer will receive the combination. The main goal is t…

This study is for people with stage IV non-small cell lung cancer whose disease has gotten worse after immunotherapy. It tests a special type of radiation called grid therapy, which delivers high doses to small parts of the tumor, combined with standard immunotherapy. The goal is…

This study tests a procedure called chemoembolization for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor, then block that artery with tiny beads. This traps the chem…

This study tests whether artificial intelligence can help doctors choose the right radiation dose for each person's lung tumor. About 70 adults with lung cancer or tumors that spread to the lung will receive stereotactic body radiation therapy (SBRT) with doses guided by an AI to…

This study tests whether giving two immunotherapy drugs (cemiplimab and fianlimab) before surgery can kill more cancer cells in people with early-stage non-small cell lung cancer. About 60 adults with stage IB to IIIB lung cancer will receive the drug combination, then have their…

This study tests a drug called amivantamab, given as a shot under the skin, for people with advanced non-small cell lung cancer that has extra copies of the MET gene. About 88 participants will receive the drug to see if it can shrink tumors or slow the cancer's growth. The goal …

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy after surgery helps people with stage II to IIIB non-small cell lung cancer live longer without the cancer returning. About 1,210 participants will receive either the combination or sequ…

This study tests whether giving the immunotherapy drug durvalumab after surgery can prevent early-stage non-small cell lung cancer from returning. About 306 people who have had their lung cancer completely removed will either receive durvalumab or be watched closely (the usual ap…

This study tests whether adding two types of focused radiation (BgRT and SBRT) to the standard drug osimertinib can better control EGFR-positive non-small cell lung cancer that has started to grow in a few new spots. About 32 adults with advanced lung cancer will receive the comb…

This study tests whether giving the cancer drug nivolumab as a shot at home is as safe and effective as getting it in a clinic. About 50 adults with various cancers will try both settings to see which they prefer and how it affects their quality of life. The goal is to reduce the…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, and also for their family caregivers. About 400 patient-caregiver pairs will take part. …

This study tests whether psilocybin, a substance from certain mushrooms, combined with talk therapy can safely help treat major depression in people with non-small cell lung cancer. About 10 participants will receive the drug and be monitored for side effects, suicidal thoughts, …

This study tests whether adding aerobic interval training (short bursts of intense exercise with rest periods) can improve immune activity and treatment response in 100 adults with non-small cell lung cancer who are already receiving immunotherapy. The goal is to see if exercise …

This study interviews 45 adults with non-small cell lung cancer who also had a past alcohol or drug problem (not tobacco). The goal is to learn what helps or hinders their cancer detection and treatment. No new drugs or treatments are tested—just conversations to identify barrier…

This study follows 2000 adults with newly diagnosed cancers (breast, colorectal, lung, melanoma, or lymphoma) who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps reduce symptoms like pain, nausea, or fatigue, and al…

This study surveys 40 adults with non-small cell lung cancer who are already receiving immunotherapy. It aims to understand their satisfaction with IV and subcutaneous treatments and whether they prefer hospital visits or home injections. The goal is to improve patient experience…

This study looks at two different ways surgeons cut blood vessels during lung cancer surgery. The goal is to see if tying off the vein first (instead of the artery) reduces the amount of tumor DNA released into the bloodstream. About 100 adults with early-stage lung cancer will h…

This study looks at how biomarkers (like DNA in the blood) can help predict whether immunotherapy will work for people with advanced non-small cell lung cancer. Researchers will collect blood and tissue samples from about 535 participants to understand treatment response and find…

This study tests a conversation aid that helps lung cancer patients and their doctors make treatment decisions together. About 100 patients with advanced non-small cell lung cancer will use the tool during appointments to see if it improves shared decision-making and satisfaction…

This study looks at how the bacteria in your gut might influence stomach issues like diarrhea and colitis caused by certain cancer drugs (immune checkpoint inhibitors). Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or genito…

This study looks at whether giving early-stage lung cancer patients information about quality of life helps them choose between surgery and radiation therapy. About 150 adults with stage I-II lung cancer who can have either treatment will take part. The goal is to see if this inf…

This study looks at patients with non-small cell lung cancer who are getting chemotherapy, radiation, and immunotherapy. Researchers collect blood, stool, saliva, and lung function data to find early signs of lung inflammation (pneumonitis). The goal is to catch problems sooner a…