KIDNEY DISEASES

This study tests the drug vorolanib in people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for patients who need a second treatment after the first one stopped working. The goal is to see how long the drug controls the cancer and what side ef…

This study tests whether using carbon dioxide gas instead of standard contrast dye during leg artery procedures can prevent serious kidney problems. About 1,960 people with blocked leg arteries and at moderate risk for kidney injury will be randomly assigned to receive either the…

This study looks at the long-term safety of a drug called zigakibart for people with IgA nephropathy, a kidney disease. It is for adults who have already finished another zigakibart study. Researchers will monitor side effects and check kidney function over 96 weeks.

This study tests two different approaches to prevent cytomegalovirus (CMV) infection in kidney transplant patients who are at high risk because the donor had CMV but the recipient did not. One group will take daily antiviral medicine for 200 days, while the other group will have …

This pilot study is testing whether providing free produce boxes can improve health outcomes for Veterans with kidney disease who also face food or nutrition insecurity. The study will track changes in blood pressure and kidney function, and also interview participants about thei…

This study tests two tools to help Black patients with advanced kidney disease get better care and delay the need for dialysis. One tool helps doctors identify high-risk patients, and the other provides health coaching. The goal is to see if these tools can help patients avoid st…

This study tests a program called NAVIGATE-Kidney for 448 adults with advanced chronic kidney disease. The goal is to help patients start kidney replacement therapy (dialysis or transplant) in a planned way, avoiding emergency starts with a central venous catheter. The program in…

This study aims to validate a test that uses a 98-peptide signature in amniotic fluid to predict kidney function after birth in fetuses with congenital anomalies of the kidney and urinary tract (CAKUT). Researchers will collect samples from 78 pregnant women across France to see …

This study looks at whether a 21-day spa program, including mineral water baths and exercise, can help people with chronic kidney and urinary tract problems. Researchers will check 150 adults (ages 40-70) before and after treatment using blood tests, urine tests, and quality-of-l…

This study aims to find kidney disease early in children by using simple urine and ultrasound tests. About 13,000 children from China will be screened and followed for 3-6 years. Those with abnormal results will be referred for further care. The goal is to build a system to predi…

This study looks at why some children with high blood pressure develop heart or kidney damage. Researchers will measure certain chemicals in the blood and urine of 125 children aged 7-18 with a new diagnosis of high blood pressure, as well as healthy children. The goal is to bett…

This study looks at how a gene called APOL1 affects kidney transplant success. African Americans and others with recent African ancestry are more likely to have a risky version of this gene. Researchers will test DNA from 5000 donors and recipients to see if the gene leads to kid…

This study is a Danish national registry that will follow 160 patients with resistant high blood pressure caused by narrowed kidney arteries. Participants will undergo a procedure called percutaneous transluminal renal angioplasty (PTRA) to open the narrowed arteries. The main go…

This study looks at kidney tissue from adults with diabetic kidney disease who are already scheduled for a kidney biopsy or surgery as part of their regular care. Researchers want to understand how SGLT2 inhibitors, a type of diabetes medicine, change the kidney's molecular finge…

This study is creating a large collection of human biological samples and health information, called a biobank. Researchers will use these materials to study the causes of diseases like cancer, heart disease, and diabetes. Up to 10,000 participants will provide samples and data t…

This study aims to understand how genes influence kidney disease risk. Anyone 18 or older living in the US can join, even if they don't have kidney disease. Participants fill out online health surveys and provide a saliva sample by mail. In return, they may receive free informati…

This study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease and early signs of heart failure. Researchers will measure heart strain, oxygen use during exercise, and blood markers. About 60 adults with mode…

This study looks at whether people who carry one copy of the cystic fibrosis gene (carriers) are more likely to have early signs of kidney and pancreas problems. Researchers will compare 1250 carriers and non-carriers using blood tests, surveys, and home-collected urine and stool…

This study looks at 500 older adults to find better ways to diagnose malnutrition, kidney disease, and dehydration. Researchers will compare new methods like body scans and blood tests to current standards. The goal is to make diagnosis more accurate for hospitalized and vulnerab…