HEART FAILURE WITH REDUCED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH REDUCED EJECTION FRACTION explained in plain language.
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Probiotic shows promise for heart failure patients
Disease control CompletedThis study looked at whether taking a specific probiotic (Lactobacillus plantarum 299v) for 12 weeks could improve exercise ability and blood vessel health in people with chronic heart failure. Ten adults with heart failure participated. The goal was to see if the probiotic could…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Medical College of Wisconsin • Aim: Disease control
Last updated May 26, 2026 06:56 UTC
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Heart failure drug combo: start both at once or one by one?
Disease control CompletedThis study looked at 62 adults with heart failure with reduced ejection fraction (HFrEF) to see if starting two medications—sacubitril/valsartan and an SGLT2 inhibitor—at the same time is as safe as starting one first and adding the other later. The goal was to check for side eff…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Universidade do Porto • Aim: Disease control
Last updated May 26, 2026 06:56 UTC
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Could a breathing pacemaker help failing hearts?
Disease control CompletedThis study tested a device that gently stimulates the diaphragm (the main breathing muscle) in people with heart failure. The goal was to see if it is safe and can improve heart function and quality of life. 35 adults with moderate-to-severe heart failure took part. The device is…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: VisCardia Inc. • Aim: Disease control
Last updated May 26, 2026 06:47 UTC
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One pill to rule them all? heart failure polypill aims to boost adherence
Disease control CompletedThis study tested a new combination pill (polypill) that packs four heart failure medications into one tablet. The goal was to see if it helps people take their medicine more regularly compared to taking several separate pills. The study included 35 adults with heart failure and …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated May 26, 2026 06:43 UTC
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Could a heart pill cut hospital visits after a heart attack?
Disease control CompletedThis study looked at whether the drug vericiguat helps people who recently had a heart attack or unstable angina and have a weak heart (ejection fraction below 45%). Researchers compared those who took vericiguat regularly to those who did not, tracking deaths, heart failure hosp…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: The First Affiliated Hospital with Nanjing Medical University • Aim: Disease control
Last updated May 22, 2026 14:04 UTC
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Lokelma allows higher heart med doses in kidney patients
Disease control CompletedThis study tested whether a drug called Lokelma (SZC) can help people with both heart failure and chronic kidney disease safely take higher doses of standard heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and high-nor…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE3 • Sponsor: St George's, University of London • Aim: Disease control
Last updated May 22, 2026 14:02 UTC
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New approach boosts use of life-saving heart failure drugs in thousands of patients
Disease control CompletedThis study tested whether a team-based program could help doctors prescribe more of the recommended heart failure medications to patients with a weak heart pump. Over 4,300 adults took part. The goal was to increase use of these drugs to reduce deaths and hospital stays.
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Geisinger Clinic • Aim: Disease control
Last updated May 22, 2026 13:54 UTC
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Heart pump patients may benefit from common diabetes drug
Disease control CompletedThis study looked at whether a type of diabetes medicine (SGLT2 inhibitors) helps people with severe heart failure who also have a mechanical heart pump (LVAD). 32 adults took the drug for 6 months. Researchers measured changes in heart size, weight, and kidney function. The goal…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: University of Chicago • Aim: Disease control
Last updated May 22, 2026 13:51 UTC
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Heart failure drug may drain excess fluid without harming blood flow
Disease control CompletedThis study tested whether ertugliflozin, a diabetes drug, can reduce excess fluid in the skin and tissues of people with heart failure without lowering blood volume. 28 adults with heart failure and reduced pumping function took the drug or a placebo in a crossover design. The go…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Disease control
Last updated May 22, 2026 13:51 UTC
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New heart procedure matches standard treatment in High-Risk patients
Disease control CompletedThis study looked at 700 people with both atrial fibrillation (an irregular heartbeat) and heart failure (a weak heart pump). It compared two catheter-based treatments that isolate the veins carrying abnormal signals to the heart: a newer method called pulsed-field ablation and a…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: St. Josefs-Hospital Wiesbaden GmbH • Aim: Disease control
Last updated May 18, 2026 12:11 UTC
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New heart failure drug shows promise in Mid-Stage trial
Disease control CompletedThis study tested a new drug called tovinontrine in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if the drug could safely lower a key heart stress marker (NT-proBNP) compared to a placebo over 12 weeks. Participants had heart failure symp…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Cardurion Pharmaceuticals, Inc. • Aim: Disease control
Last updated May 18, 2026 12:03 UTC
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Could a common diabetes pill ease rare heart condition?
Disease control CompletedThis study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking ability, and heart stress levels over…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Disease control
Last updated May 11, 2026 20:37 UTC
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New heart drug AC01 shows promise in early trial
Disease control CompletedThis study tested a new medicine called AC01 in 58 adults with a type of heart failure where the heart pumps less blood than normal. The goal was to check if the drug is safe and how the body processes it. Participants received either AC01 or a placebo, and researchers monitored …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE1, PHASE2 • Sponsor: AnaCardio AB • Aim: Disease control
Last updated May 04, 2026 16:30 UTC
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Can a computer nudge help heart failure patients get the right meds?
Knowledge-focused CompletedThis small pilot study tested whether alerts in the electronic health record could help pharmacists reach out to heart failure patients who were not taking their medications as prescribed. Only 3 pharmacists took part. The goal was to see if the system was practical and useful, n…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated May 26, 2026 06:54 UTC
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Ketone drink may boost heart efficiency in heart failure patients
Knowledge-focused CompletedThis study looked at whether taking a ketone supplement for two weeks can improve how the heart uses energy in people with chronic heart failure. Twelve patients with heart failure and reduced pumping function took the supplement or a placebo. Researchers used PET scans and heart…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Aarhus University Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 06:53 UTC
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Heart Drug's hidden powers revealed in new study
Knowledge-focused CompletedThis study looked at how Sacubitril-Valsartan, a drug already known to help people with heart failure, actually improves heart function. Researchers measured heart pressure and volume in 117 adults with heart failure and reduced pumping ability. The goal was to understand the und…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: University of Leipzig • Aim: Knowledge-focused
Last updated May 26, 2026 06:52 UTC
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AI-Powered ECG spots hidden heart failure risk years before symptoms appear
Knowledge-focused CompletedThis study tested whether artificial intelligence (AI) could predict a person's risk of developing a specific type of heart failure (HFrEF) up to five years in advance, using only a standard ECG. Researchers analyzed data from over 286,000 adults in China and the United States. T…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Shanghai Zhongshan Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 06:49 UTC
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Heart failure drug use tracked in 13,660 remote monitoring patients
Knowledge-focused CompletedThis study reviewed the medical records of over 13,000 adults with chronic heart failure enrolled in a French remote monitoring program between 2021 and 2024. Researchers wanted to see how often doctors prescribed a type of medication called SGLT2 inhibitors, and whether factors …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Satelia • Aim: Knowledge-focused
Last updated May 26, 2026 06:42 UTC