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Can short bursts of intense exercise help heart failure patients?

NCT ID NCT04248894

Symptom relief Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether high-intensity interval training (short bursts of hard exercise) is better than moderate continuous exercise for people with heart failure. Researchers measured nerve activity, blood vessel function, and muscle health in 35 participants. The goal was to see which type of exercise improves the body's ability to control blood flow and daily function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise training (high-intensity interval training and moderate-intensity continuous training)
What this could lead to
If HIIT proves better, it could offer a more effective exercise program to improve daily function and quality of life for people with heart failure.
What could go wrong
This is a small, completed study with only 35 participants, so results may not apply to all heart failure patients. Exercise programs also require careful supervision to avoid risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 35 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2015

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Functional Class II to III of New York Heart Association * Left ventricular ejection fraction ≤40% * Peak oxygen uptake (V̇O2) \<20 ml•kg-1•min-1 Exclusion Criteria: * Myocardial infarction within three months * Unstable angina * Acute heart failure * Pacemaker * Pulmonary disease * Chronic renal disease * Peripheral neuropathy * History of stroke * Untreated hypo/hyperthyroidism * Body mass index (BMI) \>30 kg/m2 * History of smoking

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Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure

Contacts and locations

Locations

  • Heart Institute

    São Paulo, Cerqueira Cesar, Brazil

  • Heart Institute (InCor)

    São Paulo, São Paulo, 05403-900, Brazil

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