New strategy aims to get lifesaving heart drugs to more patients
NCT ID NCT05990296
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed study tested whether special alerts in electronic health records and referrals to pharmacists could help doctors prescribe guideline-recommended heart failure medications more often. Over 4,300 patients with heart failure and reduced ejection fraction took part. The goal was to increase use of drugs that can reduce hospitalizations and improve survival.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Behavioral intervention: clinical decision support tools and pharmacist co-management
- What this could lead to
- If successful, this approach could help more heart failure patients get the right medications, potentially reducing hospitalizations and deaths.
- What could go wrong
- This is a completed implementation study, not a drug trial. The strategies may not work in other healthcare systems or may not change long-term outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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4,306 people
The number who actually took part.
- Started
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Aug 2023
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged 18 years or older AND * Completed visit at included Geisinger cardiology outpatient clinics (office visit or telemedicine) AND * Clinicians are on a list of currently active Geisinger clinicians in outpatient cardiology clinics who can prescribe heart failure medications AND * Active problem list diagnosis of HFrEF at time of Cardiology clinic encounter OR Left Ventricular Ejection Fraction (LVEF) \< 40: most recent to the cardiology clinic encounter within 2 years of the visit. Exclusion Criteria: * Currently in hospice or palliative care (ICD 10 code: Z51.5) * Patient is allergic to each category of GDMT * Patient is prescribed medications from all four categories of GDMT, including ARNI specifically
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Geisinger Cardiology Clinics
Danville, Pennsylvania, 17822, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can AI read heart ultrasounds as well as trained sonographers?