Heart failure with reduced ejection fraction

This trial tests a procedure called pulmonary arterial denervation (PADN) for people with heart failure who also have high blood pressure in the lungs. A special catheter delivers radiofrequency energy to nerves in the pulmonary artery, which may help lower pressure and improve h…

This study tests whether a fully online exercise program is practical and acceptable for people with heart failure. Participants are randomly assigned to either a supervised online exercise group or a self-managed home exercise program for 8 weeks. The goal is to see if people st…

This trial investigates whether intravenous infusions of tiny particles (extracellular vesicles) from heart progenitor cells can safely improve heart function in people with severe dilated cardiomyopathy and heart failure. Participants receive three infusions and are monitored fo…

This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, hear…

This study tests whether a ketone ester supplement, taken three times a day for 12 weeks, can improve heart function in people with heart failure. Fifty participants will be randomly assigned to receive the supplement or a placebo. Heart function will be measured using cardiac MR…

This study tests a new device that combines two heart therapies: one to strengthen heartbeats and another to stop dangerous rhythms. About 300 adults with heart failure and a weak heart pump will get the device. Researchers will check if it safely converts life-threatening heart …

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This study tests whether a special heart pacing technique (left bundle branch pacing) combined with standard heart failure drugs can improve heart function better than drugs alone. It includes 50 adults with non-ischemic heart failure and a specific heart block. The main goal is …

This study looks at how vericiguat, a recently approved heart failure drug, improves heart function during activity and at rest. Researchers will give 30 adults with heart failure either vericiguat or a placebo for about three months, then measure heart performance using catheter…

This early study tests a device that creates a small opening between the upper chambers of the heart to relieve pressure in people with symptomatic heart failure. The study includes 71 participants and focuses on safety and whether the device works as intended. It is not a cure b…

This study asks whether tiny RNA molecules in the blood can signal a higher risk of dangerous heart rhythms in people who have heart failure after a heart attack and use an implanted defibrillator. Researchers collect blood samples from 57 participants and compare RNA patterns be…

This early study tests a device that creates a small, temporary opening in the wall of the heart to relieve pressure and improve symptoms in people with advanced heart failure. The main goal is to see if the procedure is safe. About 20 participants who have not responded well to …

This study tests whether a 9-month program that encourages people with heart failure to gradually increase their daily steps and walking speed can improve their physical function and symptoms. Two hundred participants will either receive standard care or the step-based program, w…

This study tests a personalized approach to find the best beta-blocker dose for older adults with heart failure. Fifty participants will either receive the N-of-1 intervention (testing different doses in 2-week cycles) or enhanced usual care. The goal is to see if this patient-dr…

This study looks at whether standard blood tests for heart failure show different results in African American and Caucasian patients. Researchers will compare levels of cardiac biomarkers in 400 adults newly diagnosed with heart failure. The goal is to see if current tests miss o…

This study tests a redesigned clinical decision support tool for heart failure patients during virtual visits. The tool gives doctors medication recommendations and tips for patients to upload their vitals at home. Researchers will compare it to the usual tool in a small pilot wi…

This study tests a new computer tool that gives doctors personalized reminders when prescribing heart failure medications. The goal is to help doctors follow treatment guidelines more closely. About 764 doctors from cardiology and primary care clinics are taking part.

This trial aimed to see if an AI program could help doctors choose better heart failure treatments for each patient. It planned to compare standard care with AI-generated treatment advice. However, the study was withdrawn before enrolling any participants, so no results are avail…

This study tests whether sending cardiologists regular emails about quality goals helps them prescribe recommended medications for heart failure and atrial fibrillation. Researchers will track prescribing rates for 7,000 patients. The goal is to see if simple feedback can improve…

This study looks at tiny RNA molecules in the blood of 200 people hospitalized with acute congestive heart failure. Researchers want to see if these RNA levels change as patients receive decongestive therapy and if they can help predict who will respond well to treatment. The goa…