GENERALIZED ANXIETY DISORDER

This study is testing whether a computer-delivered therapy program can help people who have both an anxiety disorder and alcohol use disorder. Participants will use an online program that teaches skills like breathing control and problem solving to break the cycle of anxiety and …

This study tests whether using a person's genetic information to choose psychiatric medications leads to better recovery than standard prescribing. About 2,500 adults with mood, anxiety, or psychotic disorders will be randomly assigned to either gene-guided treatment or usual car…

This study tests a new program called MOMI PODS that provides extra medical and emotional support to new mothers who had pregnancy complications like high blood pressure, diabetes, or depression. About 384 mother-baby pairs will be randomly assigned to either the new program or s…

This study tests whether community health workers can help adults with chronic diseases get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health disparit…

This study is developing and testing a new internet-delivered cognitive behavioral therapy (ICBT) program for children and teens aged 8-17 with anxiety disorders. The 12-week program, guided by a therapist, uses exposure therapy to help young people face their fears. Researchers …

This study tests Velibra, an internet-based cognitive behavioral therapy program, for people on a waitlist for anxiety treatment. About 30 adults with panic disorder, social anxiety, or generalized anxiety will use the program for 6 weeks. Researchers will measure changes in anxi…

This early-phase trial is testing whether a generative AI chatbot called Therabot-CALM is usable and acceptable for people who have cannabis use disorder along with anxiety or depression. Fifteen participants will use the app for 4 weeks and give feedback through interviews and q…

This study tests whether a daily tablet called ITI-1284, taken under the tongue, can help people with generalized anxiety disorder whose current treatments aren't working well enough. About 570 adults will receive either the drug or a placebo, and researchers will measure changes…

This study tests whether a single dose of the experimental drug SYT-510 can reduce anxiety-related brain activity and behavior in 24 adults with generalized anxiety disorder. Participants will receive either the drug or a placebo, then switch after a washout period. The goal is t…

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This study tests an experimental drug called ITI-1284 for people with generalized anxiety disorder (GAD) whose current treatment isn't working well enough. About 705 adults will receive either ITI-1284 or a placebo added to their usual therapy. The goal is to see if the drug safe…

This study tests whether a single injection of RE104 can reduce anxiety symptoms in people with Generalized Anxiety Disorder (GAD). Researchers will compare RE104 to a placebo in 64 adults over 4 weeks. The goal is to see if this treatment offers a fast, effective option for easi…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study tests whether combining a gentle brain stimulation technique (tDCS) with cognitive-behavioral therapy (CBT) can reduce repetitive negative thinking in adults with generalized anxiety disorder or depression. About 85 participants will receive either real or sham tDCS du…

This study tests whether adding a computer-based music therapy that tracks eye movements (GCMRT) to standard talk therapy (CBT) works better than CBT alone for children with anxiety. About 150 kids aged 8 to 17 with separation, generalized, or social anxiety will take part. They …

This study tests whether group therapy for generalized anxiety disorder works as well as individual therapy. 64 adults with GAD will receive either group or individual metacognitive therapy. The goal is to see if group treatment can be a more accessible and cost-effective option …

This study looks at whether Swedish massage or light touch can reduce anxiety symptoms and change brain activity in people with generalized anxiety disorder. About 46 adults will receive one of two types of touch therapy twice a week for six weeks. Brain scans and questionnaires …

This study tests a new medication called crisugabalin for people with generalized anxiety disorder. About 216 Chinese adults will receive either crisugabalin, a placebo, or an existing drug (venlafaxine) for 8 weeks. The goal is to see if crisugabalin reduces anxiety symptoms bet…

This study compares two approaches to treating anxiety in children and teens aged 8-17. In stepped care, everyone starts with online therapy and gets in-person sessions if needed. In stratified care, participants are assigned to online or in-person therapy based on their needs. T…

This study tests a gentle, non-invasive brain stimulation method called cTBS to see if it can reduce anxiety in people with Generalized Anxiety Disorder. Forty adults will receive either real or placebo stimulation three times daily for a week. Researchers will use brain scans to…

This study tests a new, non-invasive treatment for people with generalized anxiety disorder who haven't gotten better with standard medications. The treatment uses low-intensity focused ultrasound to gently stimulate a deep brain area linked to anxiety, called the amygdala. 48 ad…

This study aims to find risk factors for depression and other mental health issues in medical students. Researchers will follow up to 10,000 students for up to 12 years each, using yearly questionnaires. The goal is to compare those who enter medical school with those who do not,…

This study looks at how the brain works in children aged 8-17 with anxiety or depression. Researchers use brain scans and thinking tasks to see how two standard treatments—talk therapy (CBT) or medication (fluoxetine)—affect brain activity over one year. The goal is to understand…

This study looks at whether a single session of a brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also have anxiety. Forty-six women will receive either real or fake stimulation while their heart rate is monito…

This study is testing whether a carbon dioxide (CO2) breathing challenge can identify people with anxiety, OCD, PTSD, or panic disorder who are unlikely to improve with exposure-based therapy. Researchers will give 600 adults a brief CO2 inhalation and measure their response, the…

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety handle fear. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatment. The goal is not…

This study at the University of Michigan tests whether real-time fMRI neurofeedback can help young adults with anxiety disorders better regulate their emotions. Participants will learn to control brain activity while viewing emotional images, with some receiving real feedback and…

This study looks at how exercise training impacts blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers want to understand if harmful substances called oxidants play a role in blood vessel damage. The study involve…

This study looks at how exercise might help the brain in adults with anxiety disorders. Researchers will measure certain brain chemicals from blood samples to understand the biological effects of physical activity. The goal is to learn more about the brain's response to exercise,…

This study uses a simple survey to see if people with major depression, borderline personality disorder, or generalized anxiety disorder might be eligible for industry-sponsored clinical trials. Researchers will track how many participants go on to screen for and enroll in those …

This study looks at a telephone program called SUSTAIN that helps older adults (65+) manage behavioral health issues like depression, anxiety, and chronic pain. Researchers want to understand what makes the program work best and if its benefits last over time. About 4,000 partici…

This study looks at how mindfulness-based stress reduction (MBSR) affects the brains of 150 adults with generalized anxiety disorder. Participants will be randomly assigned to either an 8-week MBSR program or a stress education class. Researchers will use brain scans and other te…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in people with depression, OCD, anxiety, or schizophrenia. Researchers will stimulate different areas of the prefrontal cortex and test how behavior changes. The goal is to understand which brain circui…