GENERALIZED ANXIETY DISORDER

This pilot study is testing whether a group-based cognitive-behavioural therapy (CBT) program can help people with generalized anxiety disorder (GAD) become more comfortable with uncertainty. About 12-20 participants will attend 12 weekly virtual therapy sessions. The goal is to …

This study tests whether a single type of cognitive-behavioral therapy (CBT) can work for several anxiety disorders, compared to therapies designed for each specific disorder. About 76 adults with panic disorder, generalized anxiety, social anxiety, OCD, or PTSD will participate.…

This phase 2a trial is testing a synthetic DMT analog called CYB004, combined with psychotherapy, in 36 adults with moderate to severe generalized anxiety disorder. The study aims to see if the drug is safe, tolerable, and can reduce anxiety symptoms. Participants must be on a st…

This study looks at whether unlicensed professionals can successfully provide cognitive behavioral therapy (CBT) to patients in a general hospital. It includes 250 adults with conditions like anxiety, depression, OCD, and PTSD. The goal is to see if this approach improves psychol…

This study compares two low-intensity family-based therapies delivered via telehealth for children aged 7-13 with anxiety or obsessive-compulsive disorder (OCD). The goal is to see if these treatments can reduce symptoms as effectively as standard therapy while being easier for f…

This study tests whether a device called CES (cranial electrotherapy stimulation) can reduce anxiety symptoms in 200 active-duty military members and their families. Participants receive either real CES or a sham (placebo) device to see if the gentle electrical pulses truly help.…

This study tests an oral medication called MM120 against a placebo in 245 adults with generalized anxiety disorder. Participants take the drug or placebo for 12 weeks, and those who complete may join a 40-week follow-up where everyone gets the active drug. The goal is to see if M…

This study looks at whether adding physical exercise to cognitive behavioural therapy (CBT) helps older adults with generalized anxiety disorder more than CBT alone. About 53 participants will receive the combined treatment. The goal is to reduce worry and increase remission rate…

This phase 3 study tests whether an oral medication called MM120 can reduce anxiety symptoms in adults with generalized anxiety disorder. About 214 participants will receive either MM120 or a placebo for 12 weeks, followed by a 40-week period where everyone can receive MM120. The…

This study compares two internet-based cognitive behavioral therapy programs for people with generalized anxiety disorder. About 400 adults will receive one of two 10-week online treatments targeting either intolerance of uncertainty or unhelpful beliefs about worry. Researchers …

This study explores whether emphasizing certain instructions on mental health questionnaires changes how people respond. Researchers will ask 200 U.S. adults with depression or anxiety to complete the same survey twice in one day, with instructions highlighted the second time. Th…

This study tests a three-session program called Omnis Salutis that teaches veterans about Whole Health and how to communicate their health needs. It involves 238 recent veterans with PTSD, depression, anxiety, or substance use disorders. The goal is to see if the program improves…