GASTROINTESTINAL NEOPLASMS

This study tests a new medicine (PF-08634404) combined with standard chemotherapy against an approved drug (bevacizumab) plus chemotherapy for people with colorectal cancer that has spread. About 800 adults who have not had prior treatment for metastatic disease will be randomly …

This study compares a new drug, IDRX-42, to the standard drug sunitinib in adults with advanced gastrointestinal stromal tumors (GIST) that have spread or can't be removed by surgery and have already been treated with imatinib. The main goal is to see if IDRX-42 delays cancer gro…

This study tests a new drug, IDRX-42, for people with advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The goal is to see if the drug is safe and can shrink or control these tumors. About 278 adults who have already tried the stand…

This study tests a new medicine called GSK5764227 in people with advanced gastrointestinal cancers that have spread and not responded to prior treatments. The goal is to see if the drug can shrink tumors and how safe it is. About 320 adults will take part worldwide.

This early-phase study tests an experimental drug called JNJ-89402638 in people with advanced colorectal or stomach cancer that has spread and not responded to prior treatments. The study aims to find the safest dose and check if combining the drug with standard therapies like be…

This study is for adults who have finished chemotherapy for gastrointestinal cancer and are in remission, but still have dangerously low platelet counts. Researchers want to see if adding a second drug (ATRA) to the standard platelet-boosting drug (romiplostim N01) works better t…

This study tests a new, dye-free way to check blood flow during gastrointestinal surgery. About 200 adults having planned gut surgery will be randomly assigned to either the new light-based method (iPPG) or the standard dye method (ICG). The goal is to see if the new method works…

This study looks at whether fecal microbiota transplantation (FMT) can reduce or prevent stomach and bowel side effects from chemotherapy in people with advanced gastrointestinal cancers. About 90 adults with stage IV cancer will receive FMT during their 4th chemo cycle. The goal…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve daily life in people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. The goal is to see if …

This study follows 8,000 adults who have precancerous or early cancerous growths in their digestive tract removed using a special endoscope. The goal is to see how often the removal is complete and safe, and to track any return of the growths over time. Researchers are collecting…

This study collects videos and images from 1,650 adults having routine upper or lower endoscopy (gastroscopy or colonoscopy) to test how well artificial intelligence can spot early gastrointestinal cancers. The goal is to see if AI can help doctors find and identify suspicious gr…