GASTROINTESTINAL NEOPLASMS

This study tests whether the drug avatrombopag can safely raise low platelet counts caused by chemotherapy in people with gastrointestinal cancers. About 60 adults will receive either avatrombopag or a placebo. The goal is to see if the drug helps patients keep their platelet cou…

This phase 3 study tests whether adding the drug durvalumab to standard chemotherapy (FLOT) before and after surgery can help people with resectable stomach or gastroesophageal junction cancer live longer without the disease getting worse. About 957 participants receive either du…

This study compares a new bipolar knife to a standard monopolar knife for removing colon growths during a procedure called endoscopic submucosal dissection (ESD). About 80 adults with colon growths will be randomly assigned to one knife. The goal is to see which knife works faste…

This study compares two ways of monitoring colorectal cancer patients after surgery: standard CT scans versus a new approach that also uses a blood test (ctDNA) to find cancer DNA. The goal is to see if the blood test helps detect cancer recurrence earlier and allows more patient…

This study looks at whether chemotherapy slows tumor growth in people with a rare type of appendiceal cancer that has spread. Researchers will compare tumor growth during chemotherapy versus no treatment in the same patient. The goal is to learn if chemotherapy is effective for t…

This study follows 138 people who had surgery for esophageal cancer to see how often they experience reflux afterward. Researchers use a simple test called PEPTEST to measure stomach acid in saliva before surgery, at discharge, and 1, 3, and 6 months later. The goal is to find pa…