GASTROINTESTINAL CANCER

This study tests a new drug called DR30206 combined with standard treatments for people with advanced or spreading gastrointestinal cancers. The goal is to see if the combination is safe and can shrink tumors. About 186 adults aged 18 to 75 in China will take part.

This study is testing several new experimental drugs called RAS(ON) inhibitors, alone or with standard chemotherapy, in people with advanced colorectal or pancreatic cancer that has spread. About 1,130 adults will participate to see if these combinations are safe and can shrink t…

This study tests a new drug called DB-1324 in people with advanced stomach, bowel, or other gastrointestinal cancers that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. About 127 participants will take…

This study tests a drug called atezolizumab in about 200 adults with advanced solid tumors (like breast, lung, or colon cancer) whose tumor DNA suggests the drug might help. Participants get the same dose every 3 weeks, and researchers check if their cancer shrinks or stops growi…

This study tests a new treatment for people with certain advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12V. The treatment involves taking a patient's own white blood cells, modifying them in a lab to better recognize…

This early-phase trial tests a combination of two targeted drugs, neratinib and fam-trastuzumab deruxtecan (Enhertu), in people with advanced stomach, esophageal, or other gastrointestinal cancers that have stopped responding to standard treatments. The main goal is to find the s…

This study tests a drug called patritumab deruxtecan in people with advanced gastrointestinal cancers that have spread. The main goals are to check the drug's safety and see if it can shrink or eliminate tumors. About 180 adults who have already tried other treatments will take p…

This early-stage study tests a combination of two drugs (sacituzumab govitecan and capecitabine) in people with advanced gastrointestinal cancers that have stopped responding to standard treatments. The main goal is to find a safe dose and see how well the body tolerates it. Abou…

This early-phase study tests a new drug, QXL138AM, for safety and tolerability in about 100 people with advanced solid tumors (like ovarian, pancreatic, or lung cancer) or multiple myeloma. Participants must have tried standard treatments without success. The study will also look…

This early-phase study tests a new treatment called GC203 TIL, which uses a patient's own immune cells that are modified in a lab to better attack cancer. The trial enrolls 18 adults with advanced solid tumors (including breast, lung, and gastrointestinal cancers) who have not re…

This early-stage study tests a new treatment for adults with advanced gastrointestinal cancer that hasn't responded to standard therapies. The treatment combines a drug called XH001 with a personalized vaccine made from the patient's own tumor markers, plus immune cells trained t…

This study tests a new way to care for cancer patients who also have other chronic conditions like diabetes or high blood pressure. It brings together cancer doctors and primary care providers to improve communication and support. The goal is to help patients better manage their …

This study tests whether a dye called CYTALUX™, given before surgery, can help surgeons see cancer tissue in real time using a special camera. It includes 15 adults with stomach, esophagus, or appendix cancer who are already scheduled for surgery. The goal is to see if this techn…

This study looks at whether different amounts of aerobic exercise (like walking or cycling) can help people with stomach or bowel cancer better tolerate chemotherapy. Researchers want to find a safe and practical exercise level that reduces side effects and helps patients complet…

This study is testing whether a remote resistance training program is practical and safe for 100 people with advanced upper gastrointestinal cancer who are receiving chemotherapy. Participants will do guided strength exercises at home using video calls. The goal is to see if most…

This study tests a new radiation technique called lattice radiation therapy (LRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better than standard radiation and whether it helps the immune system attack cancer cells. Abo…

This study tests a program called BOLSTER designed to help people with advanced gynecologic or gastrointestinal cancers and their caregivers. The program provides extra support for those with complex care needs like ostomies or feeding tubes. Researchers want to see if it improve…

This study looks at whether having a conversation about care goals in the emergency department can improve quality of life for people with advanced lung or gastrointestinal cancer. It involves 200 adults who are at least 18, have advanced cancer, and have certain severe symptoms.…

This study looks at sleep habits in people with gastrointestinal cancer and their sleep partners (like a spouse). It tests two different programs to help improve sleep quality and reduce insomnia. About 152 patient-partner pairs will join, and the study tracks sleep changes over …

This study watches how people with gastrointestinal or sarcoma cancers do on standard treatments like radiation. It collects information on cancer return and side effects to help doctors improve care. About 180 adults will take part, and no experimental drugs are given.

This early-phase study tests whether a special dye called pafolacianine (CYTALUX) can help surgeons see cancerous lesions during surgery for gastrointestinal cancer that has spread to the lining of the abdomen. Ten adults with this condition will receive the dye before surgery, a…

This study aims to find out if tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. About 120 adults with certain cancers will give blood samples and answer questionnaires before, during, and after treatment. The goal is to …

This study looks at whether a special genetic test can help doctors pick the right dose or type of medicine for people with cancer. About 120 adults with gastrointestinal or other cancers who are already getting a standard genetic test will also receive a broader test. The goal i…

This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA) can find cancer early after treatment. Researchers will follow about 100 people with different solid tumors, plus healthy volunteers, to see if the test helps predict when cancer comes back. …

This study is for adults with cancers that have spread to the lining of the abdomen. Doctors will remove most tumors during surgery, then give heated chemotherapy directly into the abdomen. They will also test the same chemo on tumor samples in the lab to see if lab results match…

This study looks at how well a simple questionnaire (SARC-F) can identify gastrointestinal cancer patients who are at risk for sarcopenia—a condition where they lose muscle mass and strength. Sarcopenia can lead to more complications and worse outcomes, even in patients who seem …

This study collects blood, tumor, and other tissue samples from up to 1,250 people with head and neck, lung, or gastrointestinal cancers. The goal is to learn how the immune system changes during cancer treatments that affect immunity. Participants donate samples and fill out que…

This study tests whether extra support—like a patient navigator, text message check-ins, and an educational video—can help Black, Latinx, and older adults (70+) with advanced cancer get the genomic testing needed to join precision cancer trials. About 210 participants with gastro…

This study is collecting blood, tissue, urine, and saliva from 7,000 people with many types of cancer to look for tiny bits of cancer DNA left after treatment. The goal is to find out if this DNA test can spot remaining cancer early and help doctors decide on next treatments. Par…

This study looks at whether adding a geriatrician to the care team can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online fitness questionnaire is easy to use and if geriatric c…

This study looks at 100 adults with gastrointestinal cancer who are scheduled for major surgery. Researchers want to see if frailty—symptoms like weight loss, weakness, and low activity—is more common in rural or urban patients. Participants will fill out a survey, give a blood s…

This study checks how many people with gastrointestinal cancer are at risk for sarcopenia—a condition where muscles weaken and shrink. Researchers will use a simple questionnaire (SARC-F) before and during cancer treatment. The goal is to find those at risk early so they can get …

This early-phase study tests whether artificial intelligence can help doctors choose and dose the right combination of cancer drugs for each person with a solid tumor (like breast or gastrointestinal cancer). Researchers will use a patient's own tumor sample in the lab to find th…

This study collects blood and tumor samples from 550 adults with gastrointestinal cancers (throat, stomach, gallbladder, liver, pancreas, or colon) to understand how the immune system fights the cancer. Participants give blood samples at the start, after 2 and 4 months, and at th…

This study looks at why cancer patients feel very tired during chemotherapy and radiation. Researchers will collect blood and stool samples from 125 adults with different cancers before, during, and after treatment. They aim to find links between fatigue and changes in genes and …

This study is testing whether a special type of PET scan (PSMA-PET) can find and monitor certain digestive system cancers, like liver, colon, and pancreatic cancers. Researchers will compare the scan results with standard imaging and tissue samples from 46 newly diagnosed patient…