GASTROINTESTINAL CANCER

This early-stage study tested a new drug called cabotamig in 33 adults with advanced gastrointestinal cancers that had stopped responding to standard treatments. The main goals were to check the drug's safety, see how the body processes it, and look for early signs it might help …

This early-phase trial tested a new type of gene therapy for advanced gastrointestinal and other cancers. Researchers collected a patient's own white blood cells, genetically modified them in a lab to recognize and attack cancer cells with a specific mutation called KRAS G12D, an…

This study tested whether adding an experimental drug called TJ004309 to an existing immunotherapy (atezolizumab) could help control advanced cancers that have stopped responding to standard treatments. It involved 25 patients with specific types of advanced solid tumors, includi…

This early-phase trial tested a new cell therapy for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Researchers collected a patient's own immune cells from a tumor, used CRISPR gene editing to remove a molecular 'brake' (CISH), a…

This small, completed study tested whether ultrasound could be a better way to detect nerve damage caused by the chemotherapy drug oxaliplatin. Researchers compared ultrasound images of leg nerves from 20 patients with gastrointestinal cancer to data from healthy people. The goal…

This study tested whether adding a specialized support team (palliative care) to work alongside surgeons improves the experience for patients and their families around major stomach or digestive system cancer surgery. It compared standard surgeon-led care to a combined approach f…

This study tested a remote nutrition support program for people with gastrointestinal cancer who had undergone surgery and chemotherapy. The program provided dietary guidance and monitoring through technology like Fitbit and video visits with a dietitian. Researchers wanted to se…

This study tested whether adding special oral nutrition drinks to standard chemotherapy could help patients with stomach, colon, or other gastrointestinal cancers. Researchers wanted to see if these supplements could improve patients' strength, quality of life, and ability to tol…

This study tested a new approach to managing side effects during cancer radiation treatment. Researchers wanted to see if having patients directly report their own symptoms to their doctors, rather than relying only on the doctor's observations, would lead to better detection and…

This study tested a support program called BOLSTER for people with gynecologic or gastrointestinal cancers and their caregivers. The goal was to help them better manage the transition home after a hospital stay by providing education, skills training, and symptom support. The res…

This study aimed to understand how a common chemotherapy drug, 5-Fluorouracil (5-FU), affects small blood vessels, which may explain its known link to heart problems. Researchers compared blood flow in the skin of 62 people across four groups: current 5-FU patients, patients on o…

This study aimed to understand why cancer patients with weight loss experience muscle weakness and fatigue. Researchers examined muscle tissue from 51 patients with gastrointestinal cancer, comparing those with significant weight loss to those without. The goal was to learn how c…

This study aimed to find the best ways to encourage doctors and patients to use a genetic test before starting certain chemotherapy drugs. The test checks for a gene change that can cause severe, sometimes fatal, side effects. Researchers gathered feedback from doctors, patients,…