GASTROINTESTINAL CANCER

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at high risk of coming back after radiation alone. About 134 adults with brain tumors from cancers like melanoma, lung, breast, or …

This study tests a new medicine called raludotatug deruxtecan in people with advanced gastrointestinal cancers, including pancreatic, bile duct, colorectal, stomach, and gastroesophageal junction cancers. The drug works like a guided missile, attaching to a protein on cancer cell…

This study tests whether the drug avatrombopag can safely raise low platelet counts caused by chemotherapy in people with gastrointestinal cancers. About 60 adults will receive either avatrombopag or a placebo. The goal is to see if the drug helps patients keep their platelet cou…

This study tests whether taking postbiotic supplements after colon cancer surgery can help restore the natural balance of gut bacteria, which is often disrupted by the procedure. Researchers will compare changes in gut bacteria diversity between 30 adults who receive the suppleme…

This early-phase trial tests a treatment for adults with metastatic solid tumors (like colorectal, lung, or breast cancer) that have a specific genetic change called KRAS. Doctors take a person's own white blood cells, modify them in a lab to better recognize and attack cancer ce…

This pilot study tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with breast, colon, lung, or other CEA-positi…

This early-stage study tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can reduce depression and anxiety in people with advanced pancreatic, biliary, or other gastrointestinal cancers. 24 participants and their family members are involved. The…

This study tests whether a chatbot combined with continuous activity monitoring via a smartphone can help detect and manage symptoms early in people undergoing chemotherapy and radiation for lung, gastrointestinal, or head and neck cancers. The goal is to reduce unplanned hospita…

This study gathers information from 100 adults with breast, lung, gastrointestinal cancer, or multiple myeloma. Participants complete weekly online surveys about their symptoms and treatment experience for at least 12 weeks. The goal is to understand how symptoms change over time…

This study looks back at medical records of 72 American Indian patients treated with immunotherapy for different cancers. Researchers want to see how long these patients lived without their cancer getting worse, their overall survival, and side effects compared to White patients.…

This study collects white blood cells and tumor samples from up to 7,000 cancer patients and healthy volunteers. The cells are used in the lab to grow large numbers of immune cells that may one day be given back to patients as experimental treatments. Participants do not receive …

This study compares two ways of monitoring colorectal cancer patients after surgery: standard CT scans versus a new approach that also uses a blood test (ctDNA) to find cancer DNA. The goal is to see if the blood test helps detect cancer recurrence earlier and allows more patient…

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. No extra procedures are d…

This study planned to track sleep quality in adults with gastrointestinal cancers before and after surgery using a simple questionnaire. It was withdrawn before any participants were enrolled, so no results are available. The goal was simply to learn more about sleep patterns, no…

This study looks at whether a new training program for nurses, called PACT, helps them better support families of patients with advanced gastrointestinal cancer. The program teaches nurses how to involve family caregivers in care and connect them with resources. Researchers will …

This study looks at whether giving doctors information about a patient's genes can help them personalize chemotherapy doses and reduce severe side effects. About 860 adults with certain cancers (like breast, gastrointestinal, or head and neck) will be randomly assigned to have th…