GASTROINTESTINAL CANCER

This study aims to improve a treatment for cancer that has spread to the lining of the abdomen. The treatment involves surgery to remove tumors, followed by a heated chemotherapy wash inside the abdomen. Researchers will test different chemotherapy drugs on tumor samples in the l…

This early-stage clinical trial is testing whether adding an experimental drug called DR30206 to standard cancer treatments is safe and effective for people with advanced gastrointestinal cancers. The study will enroll 186 adults in China with cancers like colorectal, stomach, or…

This study is testing whether a cancer drug called atezolizumab works better when given to people whose tumor DNA analysis suggests they might respond to it. It will enroll about 200 adults with various advanced, incurable solid tumors. Participants will receive the drug every th…

This study is testing a new care model called OPTIMISE, designed to improve overall health for cancer patients who also have other chronic conditions like diabetes or high blood pressure. It focuses on better communication and coordination between a patient's cancer doctor and th…

This study is testing whether giving doctors a patient's genetic information can help them personalize chemotherapy dosing. Researchers will randomly assign 860 cancer patients to either have their genetic data used to guide treatment or receive standard care. The main goal is to…

This study is testing an experimental drug called patritumab deruxtecan for people with advanced gastrointestinal cancers that have spread. The main goals are to find a safe dose and to see if the treatment causes tumors to shrink or go away. It is for adults with specific cancer…

This study is testing two new drugs, BI 765049 alone and combined with ezabenlimab, in Asian adults with advanced cancers that have a specific marker called B7-H6. The main goals are to find the highest safe dose patients can tolerate and to see if the treatments cause tumors to …

This early-stage study is testing a new two-part treatment for advanced gastrointestinal cancers that have stopped responding to standard therapies. It combines a personalized cancer vaccine with an infusion of specially trained immune cells, both designed to target the patient's…

This early-stage study is testing the safety of a new two-drug combination for people with advanced gastrointestinal cancers (like stomach, colon, or pancreatic cancer) that have continued to grow despite standard treatments. The trial will enroll about 20 patients to find the be…

This study is testing new targeted drugs called RAS inhibitors in combination with standard cancer treatments for people with advanced colorectal or pancreatic cancer. The goal is to find safe and effective doses while seeing if these new drug combinations can help control cancer…

This early-stage study is testing a new type of personalized cell therapy called GC203 TIL in adults with advanced solid tumors that have stopped responding to standard treatments. Doctors take a patient's own immune cells from a tumor, modify them in a lab to potentially fight c…

This study is testing a new type of radiation therapy called lattice radiation (LRT) for people with large cancer tumors that have spread to soft tissues. It compares LRT to standard radiation to see which is better at shrinking tumors and attracting immune cells to fight the can…

This is an early safety study to find the right dose of two drugs, neratinib and fam-trastuzumab deruxtecan, when given together. It's for adults with advanced stomach, esophageal, or other gastrointestinal cancers that have a specific marker called HER2 and have worsened after a…

This trial is testing a new type of gene therapy for people with advanced pancreatic, colon, and other cancers that have a specific genetic change called KRAS G12V. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer c…

This early-stage trial is testing a two-part personalized treatment for adults with advanced solid cancers that have spread and contain specific KRAS gene mutations. Doctors take a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cells w…

This small pilot study is testing a new, highly personalized approach to treating advanced breast or stomach cancer. For each of the 10 participants, scientists will first use lab tests on their own tumor cells to find the best drug combination. Then, an artificial intelligence (…

This study is testing whether a special fluorescent dye called CYTALUX can help surgeons see gastrointestinal cancer cells more clearly during surgery. The dye is injected before the operation and glows under special near-infrared light, potentially revealing cancer that might ot…

This is a small, early study to see if a special fluorescent dye called CYTALUX can help surgeons better see and remove cancerous spots during surgery for abdominal cancers that have spread. The dye is designed to stick to cancer cells and glow under special light. The main goal …

This study aims to help people with gastrointestinal cancer and their sleep partners get better rest. Researchers are testing two different sleep improvement programs to see which works better. The study will measure changes in sleep quality and insomnia symptoms for both patient…

This study is testing a new telehealth support program called BOLSTER for people with advanced gastrointestinal or gynecologic cancers who have complex care needs, like feeding tubes or drains. The program aims to improve patients' quality of life, ease symptoms, and reduce the b…

This study is testing whether having a structured conversation about a patient's goals and wishes for care during an emergency room visit improves their quality of life. It involves 200 adults with advanced lung or gastrointestinal cancer who are not expected to be cured. Researc…

This study is testing whether different amounts of aerobic exercise, like walking on a treadmill, can help reduce the side effects of chemotherapy for people with stomach or colon cancers. Researchers want to find the exercise level that is safe, practical, and most helpful for p…

This study is testing if a guided, at-home strength training program is safe, practical, and helpful for people with advanced stomach or intestinal cancer who are undergoing chemotherapy. Researchers will enroll 100 participants to see if the program improves muscle strength, red…

This study is testing whether a more comprehensive genetic test can help doctors prescribe safer and more effective drug doses for cancer patients. Researchers will enroll 120 adults with cancer who are already eligible for a standard genetic test related to a specific chemothera…

This study is testing a specialized PET scan that looks for a protein called PSMA, which is often found on gastrointestinal cancer cells. Researchers want to see if this scan can find more cancer sites than standard imaging and if it can help predict how patients will respond to …

This study aims to understand why cancer patients feel extreme fatigue and nerve pain during standard chemotherapy and radiation treatment. Researchers will observe 125 patients with various cancers, collecting blood and stool samples to look for biological markers linked to thes…

This study aims to collect blood, tumor tissue, and stool samples from people diagnosed with gastrointestinal cancers. Researchers will use these samples to study how the patient's immune system responds to the cancer and how gut bacteria might influence the disease. No treatment…

This study is testing a short questionnaire to identify gastrointestinal cancer patients at risk for sarcopenia—a serious loss of muscle mass and strength. Researchers want to see how many patients screen positive for this risk before starting cancer treatment and again during tr…

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This study aims to understand if muscle loss (sarcopenia) changes how patients respond to muscle-relaxing drugs used during anesthesia for gastrointestinal cancer surgery. Researchers will observe 100 patients during their operations, comparing those with and without muscle loss.…

This study tests a support program designed to help Black, Latino, and older adult cancer patients overcome barriers to getting genetic testing. Genetic testing is often required to qualify for newer, targeted cancer treatments and clinical trials. The program includes a patient …

This study aims to find out how many people with stomach or intestinal cancers show early warning signs of muscle loss, known as sarcopenia. Researchers will screen 60 patients using a simple questionnaire before they start cancer treatment and again during treatment. Patients wh…

This study aims to collect blood and tissue samples from people with head, neck, lung, or gastrointestinal cancers. Researchers will analyze these samples to learn how cancer treatments, especially immunotherapies, affect the body's immune system. The goal is to discover better w…