ANATOMIC STAGE II BREAST CANCER AJCC V8

This early-phase trial is testing a personalized vaccine made from a patient's own tumor, given alone or with drugs that boost the immune system (pembrolizumab or ipilimumab). The goal is to see if the combination is safe and can help the immune system attack triple-negative brea…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: Emory University • Aim: Disease control

Last updated Jun 23, 2026 11:57 UTC

Could 6 months of therapy be enough for some breast cancer patients?

This phase 3 trial is testing whether 6 months of HER2-targeted therapy (trastuzumab and pertuzumab) works as well as the standard 12 months for people with early-stage HER2+ breast cancer who had a complete response to initial chemotherapy. About 1,500 participants will be rando…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control

Last updated Jun 23, 2026 11:56 UTC

Could a shorter, less toxic treatment be just as effective for early breast cancer?

This study is for people with early-stage triple-negative breast cancer. It compares a shorter chemo-immunotherapy regimen without anthracyclines (a type of strong chemo) to the usual longer treatment. The goal is to see if the shorter approach works just as well while reducing s…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control

Last updated Jun 22, 2026 12:03 UTC

Vaccine boosts breast cancer fight before surgery

This study tests whether adding a vaccine called WOKVAC to standard chemotherapy and targeted therapy before surgery can help the immune system better attack HER2+ breast cancer. About 25 adults with early-stage breast cancer will receive the vaccine alongside their regular treat…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control

Last updated Jun 18, 2026 11:53 UTC

Shorter radiation before or after breast surgery may cut side effects

This study compares giving a shorter, higher-dose radiation treatment (hypofractionated radiotherapy) either before or after breast surgery in 120 adults with non-metastatic breast cancer. The goal is to see which timing causes fewer serious side effects and works better. Researc…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control

Last updated Jun 18, 2026 11:53 UTC

Breast cancer survivors: could a common diabetes drug lower your risk?

This study looks at whether metformin, a diabetes drug, can help prevent or reverse insulin resistance in women who finished chemotherapy for early-stage breast cancer. Insulin resistance raises the risk of diabetes and heart disease, and may also be linked to more aggressive bre…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: City of Hope Medical Center • Aim: Disease control

Last updated Jun 18, 2026 11:48 UTC

Could a pill replace chemo for some breast cancers? major trial launches

This study compares two treatments for people with high-stage, estrogen-positive, HER2-negative breast cancer that has a low genetic risk of returning. One group gets standard hormone therapy plus a targeted pill (ribociclib), while the other gets chemotherapy first, then the sam…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 17, 2026 12:07 UTC

New study aims to help latina breast cancer survivors lose weight and improve survival

This study tests two remote weight loss programs designed for Latina breast cancer survivors. Being overweight can worsen breast cancer outcomes, and few programs exist for this group. The study will enroll 640 women who have had breast cancer to see which approach works best for…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: NA • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control

Last updated Jun 17, 2026 12:06 UTC

New study tests cheaper drug to block estrogen in breast cancer

This study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen levels in premenopausal women with breast cancer. Both drugs work by temporarily stopping the ovaries from making estrogen, which can fuel cancer growth. The trial will enroll 75 women an…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control

Last updated Jun 16, 2026 12:51 UTC

Immunotherapy boost may stop High-Risk breast cancer from returning

This study tests whether adding an immunotherapy drug (durvalumab) to standard chemotherapy can better prevent breast cancer from coming back in people with a high-risk type of hormone receptor-positive, HER2-negative breast cancer. About 3,680 adults with stage II or III breast …

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 16, 2026 12:48 UTC

5-Day breast radiation: a game changer for cancer patients?

This study tests a new, ultra-short radiation schedule for women with stage I-III breast cancer who have had a lumpectomy. Instead of weeks of daily radiation, the whole breast and surgical cavity are treated together over just 5 days. The goal is to see if this approach controls…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control

Last updated Jun 15, 2026 19:02 UTC

New drug combo shows promise in shrinking tough breast cancer before surgery

This study tests whether adding the drug darolutamide to standard chemotherapy and immunotherapy before surgery can shrink tumors more effectively in people with early-stage androgen receptor positive triple-negative breast cancer. About 51 participants will receive either standa…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: Vandana Abramson • Aim: Disease control

Last updated Jun 15, 2026 18:56 UTC

Could less chemo be better for older breast cancer patients?

This study looks at whether giving a lower dose of two chemotherapy drugs (docetaxel and cyclophosphamide) can work well and cause fewer side effects in women aged 65 and older with early-stage HER2-negative breast cancer. The goal is to help these women complete their treatment …

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control

Last updated Jun 12, 2026 12:08 UTC

CBD oil tested for breast cancer drug side effect

This study tests whether a high-CBD plant extract can reduce joint stiffness and pain in women with breast cancer who take aromatase inhibitors. These drugs lower estrogen to prevent cancer return but often cause painful joints, leading some women to stop treatment. The trial wil…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Symptom relief

Last updated Jun 23, 2026 11:54 UTC

Exercise may sharpen memory in breast cancer survivors

This study tests whether a community-based exercise program can improve memory, attention, and brain health in women who have had breast cancer. About 160 survivors, aged 50 and older, will either take part in aerobic exercise or health education sessions. The goal is to see if p…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: NA • Sponsor: Mayo Clinic • Aim: Symptom relief

Last updated Jun 22, 2026 12:03 UTC

Tailored exercise may protect heart and fitness in breast cancer patients on chemo

This study tests whether a personalized virtual exercise program, combined with health education, helps breast cancer patients maintain their ability to exercise, heart health, and quality of life during chemotherapy. About 120 adults with stage I-III breast cancer scheduled for …

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Symptom relief

Last updated Jun 17, 2026 12:04 UTC

Can a baldness drug save hair during breast cancer treatment?

This study looks at whether minoxidil (a hair growth drug) can help with hair loss caused by hormone therapy in breast cancer patients. About 50 women with stage I-IV breast cancer who are on hormone therapy and have noticed hair thinning will either take minoxidil pills or apply…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: EARLY_PHASE1 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief

Last updated Jun 16, 2026 12:55 UTC

Brain food: MIND diet may fight chemo fog in breast cancer patients

This study tests whether a 12-week MIND eating plan can reduce memory problems, fatigue, and other symptoms in women with stage II-III triple-negative breast cancer during chemotherapy. About 60 women will be randomly assigned to either the MIND diet or general health coaching, w…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief

Last updated Jun 15, 2026 19:05 UTC

Acupuncture may help black women avoid debilitating joint pain during breast cancer treatment

This study tests whether in-person acupuncture or virtual acupressure can prevent joint pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. It focuses on Non-Hispanic Black women with early-stage breast cancer, who are more likely to stop treatment du…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: NA • Sponsor: Emory University • Aim: Symptom relief

Last updated Jun 15, 2026 19:02 UTC

Laser therapy offers hope for breast cancer survivors suffering from vaginal dryness

This study tests a laser treatment for vaginal dryness in breast cancer survivors. Many survivors experience this side effect from cancer treatments like chemotherapy or hormone therapy. The trial will compare the laser to no treatment in 250 women to see if it improves symptoms.

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Symptom relief

Last updated Jun 15, 2026 18:57 UTC

Potato starch may ease joint pain in breast cancer patients

This study tests whether a dietary supplement called resistant potato starch can help prevent joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. About 20 people with stage 0-III breast cancer or at high risk for it will take the supplement …

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Symptom relief

Last updated Jun 12, 2026 12:07 UTC

Stress relief trial aims to ease triple negative breast cancer journey

This study tests whether a 10-week stress reduction program is practical and helpful for women with early-stage triple negative breast cancer. The program teaches relaxation, coping skills, and communication, and also connects participants with social services for needs like tran…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief

Last updated Jun 03, 2026 12:04 UTC

Friends and fitness: key to life after cancer?

This study follows 250 young adult cancer survivors to see how their social relationships and physical activity change over time and how these factors affect their quality of life. Participants wear an activity tracker and complete surveys. The goal is to learn how to better supp…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Sponsor: University of Southern California • Aim: Knowledge-focused

Last updated Jun 23, 2026 21:04 UTC

Could your gut bacteria predict chemo nausea and fatigue?

This pilot study at Mayo Clinic is looking at how changes in gut bacteria might be linked to fatigue and nausea in women getting chemotherapy for early-stage breast cancer. Researchers will collect stool and blood samples and have patients fill out questionnaires before and after…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Sponsor: Mayo Clinic • Aim: Knowledge-focused

Last updated Jun 23, 2026 12:01 UTC

New tool aims to help breast cancer patients decide on preventive surgery

This study tests a decision-making tool for women newly diagnosed with breast cancer who are considering whether to have the healthy breast removed preventively (contralateral prophylactic mastectomy). The tool is designed to provide clear, balanced information. Researchers will …

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused

Last updated Jun 23, 2026 11:59 UTC

Breast cancer drug's skin side effects under the microscope

This study looks at how aromatase inhibitor therapy changes skin quality and self-esteem in breast cancer survivors. Researchers will use skin imaging and surveys to track changes in 35 women starting this hormone therapy. The goal is to better understand and manage these side ef…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Sponsor: Mayo Clinic • Aim: Knowledge-focused

Last updated Jun 23, 2026 11:59 UTC

Mayo clinic study probes immune secrets of breast cancer drugs

This study collects blood and tumor samples from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. Researchers want to see how the immune system reacts to these treatments. The goal is to learn more, not to test a new the…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Sponsor: Mayo Clinic • Aim: Knowledge-focused

Last updated Jun 22, 2026 12:09 UTC

Breast cancer survivors needed for biobank study

This study collects blood samples and health information from 1,300 women who have had stage I-III breast cancer and finished active treatment. The goal is to create a biorepository that scientists can use in the future to explore links between genes, molecules, and long-term can…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Sponsor: University of Southern California • Aim: Knowledge-focused

Last updated Jun 16, 2026 12:50 UTC

Breast cancer and sleepless nights: new study investigates the link

This study looks at how sleep changes in women with early-stage breast cancer during treatment. Researchers will track sleep patterns and check for links to stress, social support, and living environment. About 100 participants will wear a sleep monitor and answer surveys before,…

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused

Last updated Jun 11, 2026 12:12 UTC

Blood test may spot breast cancer resistance before It's too late

This study is looking at whether a blood test called DiviTum TKa can predict when hormone-receptor-positive, HER2-negative metastatic breast cancer stops responding to treatment. About 100 participants will give blood samples before and during their standard therapy. The goal is …

Matched conditions: ANATOMIC STAGE II BREAST CANCER AJCC V8

Sponsor: Mayo Clinic • Aim: Knowledge-focused

Last updated Jun 10, 2026 13:25 UTC

New ultrasound marker aims to improve breast cancer surgery guidance