ALCOHOL USE DISORDER (AUD)

This study tests whether a weekly injection of tirzepatide (a drug used for weight loss and diabetes) plus cognitive-behavioral therapy can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking days. 46 participants will receive either the drug or …

This study tests whether a natural supplement called oleoylethanolamide (OEA) can reduce inflammation, improve thinking, and lower alcohol use in young adults aged 18–25 with alcohol use disorder. Over 6 weeks, 42 participants will take either OEA or a placebo and provide blood, …

This study looks at whether adding a smartphone app to brief counseling from a nurse can help men with alcohol use disorder avoid relapse. About 74 men aged 18-59 who own an Android phone will be split into two groups: one gets only nurse counseling, the other gets the same couns…

This study tests a naltrexone implant placed under the skin to help people with alcohol use disorder drink less. About 240 adults will get either the implant or a placebo, plus counseling. The main goal is to see if the implant reduces heavy drinking days over 24 weeks.

This study tests whether online programs can help people who are not seeking treatment reduce their drinking and prevent alcohol use disorders. About 3,500 adults in Denmark will be randomly assigned to one of three internet-based programs: a brief intervention, unguided cognitiv…

This study tests a two-session, Zoom-based cognitive behavioral therapy program designed for Deaf adults who use American Sign Language. The goal is to change negative beliefs about mental health treatment and encourage participants to seek professional help. Researchers will als…

This early study tests whether a gentle electrical current applied to the scalp can help people with alcohol use disorder feel less urge to drink. Eighteen adults will receive the stimulation and report changes in cravings and drinking habits. The goal is to see if this non-invas…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. About 105 adults will stay in a hospital for 5 days, receive either CBD or a placebo alongside standard care, …

This study tests whether a smartphone app that uses machine learning can send personalized messages to help people with alcohol use disorder reduce heavy drinking and avoid relapse. About 416 adults who have recently stopped drinking will use the app and complete surveys over fou…

This early-stage study tests whether adding ketamine to talk therapy is safe and practical for people who struggle with both alcohol use disorder and major depression. Twenty participants will receive ketamine doses alongside cognitive behavioral therapy. The goal is to see if th…

This study aims to help teens (ages 12-19) with alcohol use disorder by using a visual tool called SIM-AiR. The tool helps them understand how their social groups and identities affect their recovery. Researchers will ask 60 participants and their clinicians about how useful and …

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help people who have both major depression and alcohol use disorder. Thirty adults will receive either psilocybin or a placebo, along with therapy sessions. The main goal is t…

This study explores whether listening to music can help young adults (ages 18-35) manage stress during their first year of recovery from alcohol use disorder. Researchers will use a smartphone app and a wearable device to detect stress in real time and suggest calming music. The …

This study compares how people with alcohol use disorder think and feel versus those without the condition. Researchers will use questionnaires to measure psychological processes, depression, and anxiety. The goal is to better understand the mental patterns linked to alcohol prob…

This study uses a special PET scan to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers will compare these scans to those of healthy volunteers to see if the protein levels differ. The goal is to better understand the brain changes link…

This study tests whether a virtual reality version of the Multiple Errands Test can accurately assess executive functions (like planning and problem-solving) in people with alcohol use disorder. About 90 participants will complete both a real-life and a virtual supermarket task, …

This study looks at how things like air pollution, noise, and lack of green spaces in cities may affect mental health. Researchers will track 680 people with depression, anxiety, or alcohol use disorder, plus healthy volunteers, using wearable devices and a smartphone app. The go…