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Alcohol use disorder (AUD)
Clinical trials for Alcohol use disorder (AUD) explained in plain language.
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Could a blood pressure drug curb alcohol cravings?
Disease control OngoingThis study tests whether a drug that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel less craving. About 184 adults who want to cut back or quit drinking will take the drug or a placebo and report their drinking and cravings. The goal is to …
Matched conditions: ALCOHOL USE DISORDER (AUD)
Phase 2 • Sponsor: Brown University • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Can a psychedelic compound help veterans and first responders with PTSD and alcohol use disorder?
Disease control OngoingThis phase 2 trial is investigating whether psilocybin, the active compound in magic mushrooms, combined with psychological support, is safe and suitable for military veterans and first responders who have both alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). …
Matched conditions: ALCOHOL USE DISORDER (AUD)
Phase 2 • Sponsor: Nathan Brashares Sackett • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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Could a seizure drug curb alcohol cravings? new trial investigates
Disease control OngoingThis phase 2 trial tests whether zonisamide, a drug currently used for seizures, can help adults with alcohol use disorder drink less. About 205 treatment-seeking participants will receive either zonisamide or a placebo, along with standard support. The study measures alcohol con…
Matched conditions: ALCOHOL USE DISORDER (AUD)
Phase 2 • Sponsor: Washington State University • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Could an asthma drug curb alcohol cravings? new trial investigates.
Disease control OngoingThis study tests whether ibudilast, an anti-inflammatory drug used in Japan, can help people with alcohol use disorder drink less. Fifty adults will take either ibudilast or a placebo for 6 weeks, plus counseling. The main goal is to see if it reduces the number of heavy drinking…
Matched conditions: ALCOHOL USE DISORDER (AUD)
Phase 2 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Non-alcoholic beer tested as a recovery aid for alcohol use disorder
Symptom relief By invitation onlyThis pilot study is testing whether giving people non-alcoholic beer or sparkling water can help them reduce their alcohol intake. 60 adults with alcohol use disorder who are already in treatment will receive one of the two drinks for 6 weeks. The main goal is to see if people fi…
Matched conditions: ALCOHOL USE DISORDER (AUD)
Sponsor: Stanford University • Aim: Symptom relief
Last updated Jul 22, 2026 00:00 UTC
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Sound waves against alcohol cravings: new ultrasound therapy tested
Symptom relief OngoingThis study tests whether a non-invasive ultrasound treatment on the brain can lower cravings and help prevent relapse in people with alcohol use disorder. About 40 adults will be randomly assigned to receive either the real ultrasound or a fake (sham) treatment, and neither they …
Matched conditions: ALCOHOL USE DISORDER (AUD)
Sponsor: Shanghai Mental Health Center • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Ketone drink may shed light on Alcohol's toll on brain and heart
Knowledge-focused By invitation onlyThis study looks at how a single dose of a ketone ester supplement (DeltaG) changes glucose use in the brain and heart of people with alcohol use disorder compared to healthy volunteers. Twenty participants will receive either the supplement or a placebo, then undergo PET scans. …
Matched conditions: ALCOHOL USE DISORDER (AUD)
Phase 2/3 • Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Can we predict who will succeed in alcohol group therapy?
Knowledge-focused OngoingThis study follows 120 people in group therapy for alcohol use disorder to see which patient factors—like mental health, drinking severity, personality, or thinking skills—predict who finishes treatment and stays sober a year later. Researchers hope to learn how to match patients…
Matched conditions: ALCOHOL USE DISORDER (AUD)
Sponsor: The Hospital of Vestfold • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:22 UTC