ALCOHOL USE DISORDER (AUD)

This study tests a non-invasive brain stimulation technique called deep TMS to help Veterans with Alcohol Use Disorder reduce relapse. Researchers will use brain scans to see how the treatment affects emotional processing and drinking behavior. 100 participants will be followed f…

This study looks at whether adding a smartphone app to standard medication helps Veterans with alcohol use disorder drink less heavily. About 330 Veterans from VA primary care will either get medication alone or medication plus the app. The goal is to see if the app makes treatme…

This study tests whether a psychedelic drug called DMT, combined with talk therapy, can help people with alcohol use disorder drink less. About 63 adults with alcohol use disorder will receive either DMT or a placebo in a controlled setting. Researchers will check if the treatmen…

This study explores whether suvorexant, a drug currently used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. Researchers will compare suvorexant to a placebo in 180 adults (ages 18-75) with AUD who are underg…

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce the desire to drink and lower heavy drinking days in people with alcohol use disorder. About 86 adults who drink heavily will receive either real or fake (sham…

This study tests whether two doses of LSD can help people with alcohol use disorder drink less heavily. 128 adults who have recently stopped drinking will receive either a low or moderate-to-high dose of LSD in a supervised setting. The main goal is to see if LSD reduces the numb…

This study is testing whether a combination of ketamine (a medicine) and real-time brain training (neurofeedback) can help people with alcohol use disorder drink less. About 75 adults who want to reduce or stop drinking will receive either ketamine or a placebo, along with real o…

This small pilot study is testing whether tirzepatide, a drug used for diabetes, can help people with alcohol use disorder reduce their cravings for alcohol. Twenty adults will receive weekly injections of either tirzepatide or a placebo for 4 weeks. The goal is to see if the dru…

This study tests whether a drug that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel fewer cravings. Researchers want to understand how stress plays a role in drinking. About 184 adults who want to cut back or quit drinking will take the med…

This study tests whether probenecid, a medication currently used for gout, can help people with alcohol use disorder drink less and feel less craving. About 120 adults who drink heavily will take probenecid or a placebo daily for 16 weeks. Researchers will measure cravings in the…

This study is testing whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Researchers will enroll 30 adults with HIV and alcohol use disorder to see if the treatment is practical, safe, and effective. The goal is to improve h…

This early-phase study tests whether a new sublingual medication (BXCL501) is safe and shows promise for people who drink heavily and also have PTSD. Ten adults aged 21–65 will take the drug and be monitored for changes in anxiety, PTSD symptoms, and alcohol use over 28 days. The…

This early-stage study tests whether diclofenac, a common anti-inflammatory drug, can help people with alcohol use disorder by changing brain chemistry. Researchers will give 24 adults either a placebo or one of three doses of diclofenac to see if it reduces alcohol cravings and …

This study is creating and testing a short, virtual therapy program for LGBTQ+ people who have experienced trauma and use alcohol. In the first part, participants share their thoughts to make the program more helpful and inclusive. In the second part, some participants can try th…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people with substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with psychological…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This early-stage study looks at whether tirzepatide, a drug used for diabetes and weight loss, changes brain activity related to alcohol cravings. About 176 adults with alcohol use disorder and healthy volunteers will receive tirzepatide or a placebo and undergo brain scans. The …

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…

This study is testing whether a smartphone app can help young people aged 14 to 35 with alcohol or cocaine use disorder by training their brain to say "no" to substance-related cues. Participants will use the app for short training sessions over a month, plus booster sessions. Th…