Ketone drink may shed light on Alcohol's toll on brain and heart
NCT ID NCT05015881
First seen Apr 10, 2026 · Last updated Jun 19, 2026 · Updated 15 times
Summary
This study looks at how a single dose of a ketone ester supplement (DeltaG) changes glucose use in the brain and heart of people with alcohol use disorder compared to healthy volunteers. Twenty participants will receive either the supplement or a placebo, then undergo PET scans. The goal is to better understand the link between alcohol misuse and energy metabolism in these organs.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of Pennsylvania Center for Studies of Addiction
Philadelphia, Pennsylvania, 19104, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketone ester (DeltaG)
What this could lead to
If successful, this could reveal how ketone esters affect brain and heart energy use in alcohol use disorder, pointing toward new ways to understand or manage the condition.
What could go wrong
This is a very small, early-stage study with only 20 participants, so results may not apply broadly. It measures short-term effects after a single dose, not long-term outcomes.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.