ADOLESCENT

This study looks at whether involving a parent or caregiver in a brief counseling session at the doctor's office helps teenagers ages 12-17 drink less alcohol. Some teens will have a session alone, some with a parent present, and some with an online program for parents. The goal …

This study tests a new treatment for children, teens, and young adults (ages 2 to 34) with newly diagnosed classical Hodgkin lymphoma. The drug brentuximab vedotin replaces two older drugs in the standard chemo mix, with the goal of achieving a faster complete response on PET sca…

This study, called CAMPFIRE, is a master protocol that helps researchers test multiple new cancer drugs in children and young adults more efficiently. About 105 participants with different types of cancer will join, and each will receive a drug tailored to their disease. The goal…

This study tests whether a daily pill called dapagliflozin (an SGLT2 inhibitor) can reduce protein leakage in the urine of teenagers aged 14–18 with mild chronic kidney disease. About 200 participants will receive either the drug or a placebo for six months. The goal is to see if…

This study tests a drug called romiplostim N01 in children and young adults (ages 6-24) whose platelet counts drop dangerously low after chemotherapy. The goal is to see if weekly injections can safely bring platelet levels back up within three weeks. About 50 participants will r…

This study tests whether a single injection of Telpegfilgrastim works better than multiple daily injections of Filgrastim to prevent fever and dangerously low white blood cell counts caused by chemotherapy in children and teens (ages 6-24) with solid tumors. About 132 participant…

This study tests whether giving tuberculosis (TB) preventive medicine right away to children and teens who live with a TB patient can prevent them from getting infected. About 647 participants aged 5 to 17 will either get immediate treatment or standard care. The goal is to see i…

This study tests whether a special nerve block (PECS) given before surgery can lower the amount of strong pain medicine (opioids) children need after getting a heart device like a pacemaker. About 48 kids aged 3-18 will be randomly assigned to get either the nerve block or standa…

This study tests whether adding a low dose of esketamine (a fast-acting anesthetic) to standard electroconvulsive therapy (ECT) can improve depression outcomes in adolescents aged 13-17 with severe depression. About 220 participants will be randomly assigned to receive either esk…

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can reduce depression symptoms in adolescents with bipolar disorder. One hundred teens will receive either real or sham stimulation over two weeks, alongside their usual care. Researchers will also…

This study is testing a digital program designed to help adolescent and young adult cancer survivors (ages 15-39) manage symptoms of depression. The program includes educational content and four evidence-based strategies. Researchers want to find out which parts of the program wo…

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in teenage refugees. About 80 participants aged 14 to 18 will be randomly assigned to either the START NOW program or standard care. Researchers will compare c…

This study looks at whether a special 3D exercise program (the Schroth method) can help teenagers aged 12-18 with hyperkyphosis (excessive rounding of the upper back). The goal is to see if these exercises improve back muscle endurance, reduce pain, enhance sleep quality, and boo…

This study looks at whether a simple breathing practice is a practical and well-liked option for teenagers aged 12 to 17 who have anxiety or depression. Researchers will work with 40 teens from both rural and non-rural areas to see if they can stick with the program and find it h…

This study gathers movement data from 40 healthy children and teens aged 3 to 25. Using cameras and force plates, researchers measure how they move during activities. The goal is to create a baseline of normal movement, which can later help doctors better understand and treat kid…

This study looks at why Hispanic teenagers often wait longer for knee surgery after an injury, which can lead to long-term problems like arthritis. Researchers will interview athletes, families, and coaches to understand barriers such as insurance or language issues. Then they wi…

This study looks at why teenagers with testicular torsion wait more than 6 hours before going to the hospital. Researchers will survey 150 boys aged 10-18 who had surgery for this condition between 2020 and 2025. The goal is to find out what barriers—like embarrassment, fear, or …

This study explores the personal experiences of adolescents with anorexia nervosa, their parents, and healthcare professionals regarding the use of psychotropic drugs. Researchers will conduct in-depth interviews to understand perceptions and feelings about these medications. The…

This study will follow 1,000 teenagers hospitalized for depression or bipolar disorder. Researchers will collect blood samples, brain scans, wearable device data, and psychological tests to find patterns that predict how well a teen responds to treatment. The goal is to better un…

This study looks at how trauma-focused therapy changes brain connections in teenagers with PTSD. Researchers will use brain scans before and after each phase of therapy to understand which brain networks improve. The goal is to find out how therapy works in the brain, which could…

This study is testing a family support program called Promoting Positive Family Futures (PPFF) for families in Palestine affected by ongoing conflict and violence. About 300 families with a teen aged 13–16 will be randomly assigned to either the program or usual services. Researc…