Respiratory tract infectious disorder

This trial is testing an updated version of the BNT162b2 COVID-19 vaccine in healthy adults aged 18 to 64. Participants will receive either the updated COVID-19 vaccine or a Tdap vaccine (for tetanus, diphtheria, and whooping cough) to compare safety and measure spike protein lev…

This study tests personalized phage therapy in people with serious infections that have not responded to antibiotics or surgery. Researchers will collect data before, during, and after treatment to see how safe and effective phage therapy is, and how it affects different body sit…

This large Phase 3 trial is testing an experimental drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. Participants receive either a single dose of tozorakimab or a placebo, added to standard care. The main goal is to see…

This phase 3 trial tests a new antiviral pill, ibuzatrelvir, alone or with an IV drug (remdesivir) in 300 adults with weak immune systems who have mild-to-moderate COVID-19. The goal is to see if the combination prevents hospitalizations or worsening symptoms better than remdesiv…

This study tests whether children with bacterial infections like urinary tract infections, cellulitis, or pneumonia can safely stop oral antibiotics once their symptoms go away, instead of finishing the entire course. About 200 children aged 1 to 17 who have already received IV a…

This study tests an oral medication called ibuzatrelvir in adults and teens with COVID-19 who are not hospitalized but have a high risk of becoming severely ill. Participants will receive either the drug or a placebo for 5 days, and researchers will track whether it reduces emerg…

This study tests whether a 2-month combination of four drugs can cure drug-susceptible tuberculosis in children under 10 as safely and effectively as the standard 4- to 6-month regimen. Researchers will enroll 860 children, including those with HIV, to compare the shorter treatme…

This trial investigates whether a rapid C-reactive protein (CRP) blood test can help doctors decide when antibiotics are truly needed for adults with acute respiratory infections in Indonesian primary health clinics. Many such infections are viral and do not require antibiotics, …

This study tests whether a daily probiotic supplement (Antrrix) can reduce the frequency and severity of respiratory infections in children under 6 who get sick often. Over 8 weeks, 120 kids will receive either the probiotic or a placebo. Researchers will track symptoms and quali…

This study tests whether ColdZyme mouth spray can lower the amount of virus people breathe out when they have a cold or flu. Researchers will measure virus particles in exhaled air before and after using the spray. The goal is to see if the spray might help reduce airborne transm…

This study tests whether giving oral antibiotics instead of IV antibiotics is just as safe and effective for patients with common infections like pneumonia, urinary tract infections, and cellulitis. About 4,000 adults in Danish emergency rooms will be randomly assigned to start o…

This study tests a new drug called AV-001 in 120 hospitalized adults with pneumonia who need extra oxygen. The drug is given daily for up to 28 days alongside standard care. The goal is to see if it is safe and helps patients recover faster from pneumonia caused by COVID-19 or ot…

This early-phase trial tests the safety and tolerability of a new antibiotic called JKN2501 in 66 healthy adults in China. Participants receive either the drug or a placebo by IV infusion, and researchers monitor for side effects and how the drug moves through the body. The goal …

This study tests a new technology called Pictura Bio that aims to detect respiratory viruses quickly and cheaply from nose or throat swabs. Researchers will collect samples from 1000 adults and children with suspected viral infections at a UK hospital. The data will be used to tr…

This study tests an electronic decision support tool to help doctors diagnose and treat lower respiratory tract infections. About 765 patients in Sri Lankan hospitals will use the tool, and researchers will compare their outcomes and antibiotic use to those receiving usual care. …

This study is testing a finger-prick blood test called FebriDx in 800 children aged 2-11 who have a fever and symptoms of a respiratory infection. The goal is to see if the test can quickly tell whether the infection is caused by bacteria or something else (like a virus). If accu…

This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study is testing a new diagnostic tool that helps doctors quickly tell if a respiratory infection is caused by bacteria or a virus. The goal is to see if using this test leads to better treatment decisions, fewer unnecessary antibiotics, and lower healthcare costs. About 100…

This study tests whether an AI-powered app can help doctors more accurately diagnose ear infections in young children (6-24 months) with cold symptoms. Researchers will compare standard ear exams with the AI app's analysis of eardrum photos. The goal is to see if the AI reduces u…

Karamoja in north-eastern Uganda is one of the most water-insecure regions in sub-Saharan Africa, and many schools lack enough latrines and menstrual health facilities. Researchers are running a three-arm cluster-randomised trial across 60 water-insecure primary schools to test a…

Researchers are testing whether a bacterial lysate, a mix of inactivated bacteria, can reduce respiratory tract infections and wheezing in late-moderate preterm infants during their first years of life. The trial enrolls 500 infants born between 30 and 35 weeks of gestation, givi…

This study tests whether a special fish oil (Omega Cold) can help healthy adults avoid or recover faster from colds, flu, and COVID-19. Four hundred participants aged 18–80 will take either the fish oil or a placebo daily for four months during flu season. They will report any sy…

This study tests whether PMBL® sublingual tablets can reduce the number of respiratory infections (like colds) in children aged 3 to 12 who are prone to getting sick. Half the children will receive the active tablet, and half will receive a placebo (inactive tablet) for 3 months,…

This study tests whether giving both an RSV vaccine to pregnant women and an antibody shot to their babies prevents RSV infection better than giving only the baby shot. About 1000 pregnant women in France will be randomly assigned to one of two groups. The goal is to see if the c…

This study tests whether Buccalin tablets can reduce the number of lower respiratory tract infections in adults who get them often. 240 participants will receive either Buccalin or a placebo for 12 months. The goal is to see if the treatment lowers infection episodes compared to …

This study is testing whether taking high-dose fish oil supplements during pregnancy can prevent asthma and persistent wheezing in early childhood. The trial will enroll 2000 pregnant Danish women with low blood levels of omega-3s. Participants take fish oil or placebo capsules d…

This study is testing whether taking a higher dose of vitamin D during pregnancy can prevent asthma and persistent wheezing in children up to age 3. Researchers will give 2000 pregnant women either vitamin D or a placebo daily from week 22-26 of pregnancy until one week after del…

This study tests whether a daily probiotic supplement (Lacticaseibacillus rhamnosus CRL1505) can prevent upper respiratory infections like colds and flu in healthy children aged 3 to 12. Over 268 kids will take either the probiotic or a placebo for 12 weeks, then be followed for …

This phase 3 trial tests whether a single dose of baloxavir helps non-hospitalized adults with mild-to-moderate influenza recover faster compared to a placebo. About 264 participants will be enrolled within 5 days of symptoms and tracked until they feel fully recovered. The study…

This study tests whether adding lymphatic pump osteopathic manipulative therapy (OMT) to standard care helps older adults recover faster from respiratory illnesses like bronchitis, sinusitis, or pneumonia. Participants aged 65 to 100 with a new respiratory diagnosis will receive …

This study tests whether adding remimazolam to standard sedation (propofol and alfentanil) can lower the risk of low oxygen levels in high-risk patients during painless tracheoscopy. About 360 participants with serious health conditions (ASA class 3-4) will be randomly assigned t…

This study tests whether a liquid medicine called Rengalin can safely reduce coughing in children aged 6 months to 3 years who have a viral cold or flu. About 264 children will take either Rengalin or a placebo three times a day for 7 days. The main goal is to see if more childre…

This study tests a new way to give oxygen during a sedated lung scope (bronchoscopy). Normally, patients can have dangerously low oxygen levels because the scope and sedation block the airway. The new method uses a thin, flexible tube placed through the nose to deliver oxygen dir…

This study looks at how well seawater nasal sprays work in everyday life for people with nasal and sinus issues like colds, allergies, or after surgery. About 1065 people of all ages, including pregnant women, will use the sprays and report their symptoms. The goal is to see if t…

This study tests whether a nasal decongestant spray given before anesthesia can reduce breathing complications in children aged 1 to 8 who have a cold and need surgery. Two hundred children will receive either the active spray or a placebo, and doctors will monitor for issues lik…

This study gathers fluid and tissue from the lungs and nose of healthy volunteers and people with a history of lung infections. Researchers will compare samples to find differences in immune function that might explain why some people are more prone to infections. Participants un…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This study will follow 2,000 people of all ages who visit their doctor with symptoms of an acute respiratory infection, like cough, sore throat, or runny nose. Researchers will collect information on symptoms, treatments, and lab results to better understand how these infections …

This study tests whether a rapid nose swab test that detects three common respiratory viruses (COVID-19, flu, and RSV) can help doctors avoid prescribing antibiotics when they aren't needed. About 2,000 people with respiratory symptoms will be enrolled. Doctors will either prescr…

This study is recruiting 160 people — half who carry one copy of the cystic fibrosis (CF) gene and half who do not — to see if carriers have different risks for respiratory infections. Researchers will collect nasal cells and blood samples to measure how well the cells move chlor…

This study will track which respiratory viruses—like flu, COVID-19, and RSV—are circulating in French primary care clinics each winter. Up to 25,000 patients with cold or flu symptoms will provide a saliva or nose swab sample. The goal is to monitor virus activity and help guide …

This study aims to identify the types of fungi causing pneumonia in immunocompromised ICU patients and test how resistant they are to antifungal drugs. Researchers will collect samples from 250 adults in intensive care who have pneumonia that does not respond to antibiotics. The …

This study investigates the range of symptoms children with newly diagnosed asthma may experience, including less common ones like recurrent pneumonia, chronic wet cough, or difficulty breathing in. By tracking 80 children aged 3 to 18, researchers aim to better understand how of…

This study tracks respiratory infections in thousands of patients across China to build a better early warning system. Researchers collect routine medical data and samples to identify which germs are circulating and how the body responds. The goal is to help hospitals and health …

This study tests whether implementing new Swiss national guidelines for acute respiratory infections can reduce unnecessary antibiotic prescribing in primary care. Researchers will work with 200 family doctors in quality circles and walk-in clinics, providing training and materia…

This study is observing 2,000 children under 2 years old in Ho Chi Minh City who have respiratory infections. Researchers will test for RSV, track how the virus spreads across seasons, and measure the illness's impact on families, including medical costs. No new treatments or vac…

This study tests two ways to help general practitioners (GPs) use antimicrobial stewardship resources when treating respiratory tract infections. One group gets online training and self-audit tools; the other gets face-to-face support. Researchers will track how often GPs use the…

This study looks at how serious respiratory infections (like flu, COVID-19, and RSV) affect the ability of adults aged 60 and older to live independently. Researchers will follow 1,600 hospitalized seniors across multiple countries to track changes in daily activities such as bat…

This study looks at whether a quick lab test (Spotfire R/ST) can help doctors decide when antibiotics are truly needed for people with respiratory infections like colds or sore throats. About 800 urgent care patients will take part, and researchers will compare antibiotic use bef…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This observational study follows 400 women aged 40-60 to compare respiratory infection rates between those taking hormone replacement therapy (HRT) and those not. Participants wear a smartwatch to track vital signs and report symptoms for six months. The goal is to understand if …

This study will follow 1,000 adults who come to fever clinics with a respiratory infection. Researchers will collect data on symptoms, lab tests, and chest scans at the start, then check in over time to see who develops pneumonia or other complications. The goal is to better unde…

This study in Kyrgyzstan is testing whether using a rapid C-reactive protein (CRP) blood test and giving patients an information leaflet can help doctors prescribe fewer antibiotics for respiratory infections like coughs and sore throats. About 1050 adults will be randomly assign…

This study follows 1,088 newborns in Colombia and Panama until age 5 to learn how often respiratory infections happen, which viruses or bacteria cause them, and why some children get sicker than others. Families report symptoms twice a week and provide nasal and blood samples dur…

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This study investigates whether certain autoantibodies that block the body's natural antiviral defenses lead to higher viral levels and slower recovery in severe respiratory infections like flu, RSV, and COVID-19. Researchers will measure viral load changes over a week in 360 ICU…

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…