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Simple nose spray may keep kids breathing easy during surgery

NCT ID NCT07000877

Symptom relief Sponsor: Telethon Kids Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a nasal decongestant spray given before anesthesia can reduce breathing complications in children aged 1 to 8 who have a cold and need surgery. Two hundred children will receive either the active spray or a placebo, and doctors will monitor for issues like coughing, airway blockage, or low oxygen. The goal is to find a simple, low-risk way to make anesthesia safer for kids with upper respiratory infections.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
oxymetazoline hydrochloride (0.05%) nasal spray
What this could lead to
If it works, this simple nasal spray could become a standard way to reduce breathing problems in children with colds who need surgery.
What could go wrong
This is a small, early-phase trial, so results may not apply to all children. The spray might not reduce complications significantly compared to a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 year to 8 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged 1 to 8.99 years with a current or recent upper respiratory tract infection (\<2 weeks). * Undergoing interventions or surgery under general anesthesia (elective or urgent not emergency). Exclusion Criteria: * Currently taking nasal decongestants (past 24 hours) or receiving co-phenylocaine or decongestion for surgery. * Surgery impacting the nasal airflow, e.g. adenoidectomy, cautery of inferior turbinates. * Airway management with an endotracheal tube, face mask or high flow nasal oxygen. * Known cardiovascular, respiratory or neurological disorders giving an ASA III or above. * Thyroid disease. * Diabetes. * Known hypersensitivity to the interventional products. * Department of Child Protection and Family Services involved in their care. * Planned admissions to the Paediatric Intensive Care Unit (PICU).

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Conditions

The condition(s) this trial relates to.

respiratory tract infectious disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia outcomes Perioperative respiratory adverse events

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Perth Children's Hospital

    RECRUITING

    Perth, We, Australia

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