Pulmonary arterial hypertension

This early-stage study by Pfizer tests a new drug called PF-07868489. First, it will be given to healthy volunteers to check safety and how the body processes it. Then, people with pulmonary arterial hypertension (PAH) will receive repeated doses over 24 weeks to see if it helps …

This Phase 2 trial tests whether satralizumab, an antibody that blocks IL-6 (a protein involved in inflammation), can improve blood flow in the lungs of people with pulmonary arterial hypertension (PAH). The study includes 20 adults in Japan who have high IL-6 levels and haven't …

This study tests whether a new generic tablet containing selexipag works the same as the brand-name drug Uptravi. Healthy adults aged 18 to 55 take a single dose of each version under fed conditions, and researchers compare how much drug gets into the bloodstream. The goal is to …

This study investigates whether eccentric cycling—where the pedals resist the rider's effort, similar to walking downhill—can improve exercise capacity in people with heart or lung conditions. Unlike normal cycling, eccentric cycling demands less oxygen, which may allow patients …

This study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if rali…

This study tested a drug called sotatercept (MK-7962) in 46 Japanese adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took the drug alongside their usual treatments. The main goals were to see if it improve…

This study looked at whether bosentan (Tracleer) can reduce the thickness of lung artery walls in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension, or PAH). Eleven adults with PAH took bosentan for 6 months. Researchers measured artery wall …

This study tested a drug called sotatercept in 173 people with severe pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work too hard. Participants received either the drug or a placebo on top of their usual treatments. The goal was to see if th…

This study tested an inhaled medication called seralutinib in 390 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe and limits physical activity. The goal was to see if the drug improves how far patients can walk in six minu…

This study tested the drug macitentan in 7 Japanese children aged 3 months to 15 years with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs strains the heart. The goal was to see if the drug improves blood flow and heart function after 24…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This study tested whether the drug sotatercept, given for 36 weeks, improves how the heart and lungs work during exercise in people with pulmonary arterial hypertension (PAH). Thirty adults with PAH received injections of sotatercept. Researchers measured heart pressure, blood fl…

This study looked at how the drug CS1 changes the structure of small lung arteries in people with pulmonary arterial hypertension (PAH). Seven patients already taking CS1 in an expanded access program had special CT scans at the start and after 12 months. The goal was to see if C…

This phase 2b trial tested an inhaled powder form of treprostinil palmitil in 102 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe. The study compared the drug to a placebo to see if it could lower lung…

This study tested the drug macitentan in 165 children with pulmonary arterial hypertension (PAH), a serious lung condition. The children were randomly assigned to receive macitentan or standard care. The main goal was to see how the drug behaves in the body and whether it is safe…

This completed phase 3 trial tested whether giving children with pulmonary hypertension two drugs (sildenafil and bosentan) from the start works better than just one drug (sildenafil alone). The study enrolled 28 children who had not yet received long-term treatment. Researchers …

This study tested two drugs, levosimendan and dobutamine, in 52 adults undergoing heart valve replacement. The goal was to see which one better preserves right ventricular function after surgery. Patients were randomly assigned to receive one of the drugs, and their heart functio…

This study tested the drug dapagliflozin (used for diabetes and heart failure) in 52 adults with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension. The goal was to see if it improves exercise capacity and heart function. Participants took the …

This study tested whether a single pill containing two drugs (macitentan and tadalafil) works better than taking either drug alone for people with pulmonary arterial hypertension (PAH), a serious lung condition. 187 adults with PAH took either the combination pill or one of the s…

This study looked at two ways of giving the drug sotatercept to people with pulmonary arterial hypertension (PAH), a condition where lung blood vessels narrow, making it hard to breathe. Researchers compared a standard weight-based dose to a simpler weight-banded dose to see how …

This study looked at how an inhaled drug called treprostinil helps patients with pulmonary hypertension caused by interstitial lung disease. Researchers measured heart function and breathing efficiency during exercise after 3 months of treatment. The goal was to understand how th…

This study tested whether DHEA, a natural hormone, can improve heart function in people with pulmonary arterial hypertension (high blood pressure in the lungs). 26 adults took DHEA or a placebo for 18 weeks, then switched. The main goal was to see changes in heart strain measured…

This large Phase 3 study tested whether selexipag, a daily pill, can delay serious complications or death in people with pulmonary arterial hypertension (PAH), a rare condition of high blood pressure in the lungs. Over 1,100 adults with PAH received either selexipag or a placebo.…

This study looked at the long-term safety of the drug riociguat (Adempas) in adults with pulmonary arterial hypertension (PAH), a type of high blood pressure in the lungs. It included 18 people who had already taken riociguat in earlier Bayer studies. The main goal was to track s…

This study tested a procedure called pulmonary artery denervation (PADN) for people with pulmonary arterial hypertension (PAH), a condition where blood pressure in the lungs is dangerously high. 128 adults received either the real procedure or a sham (fake) procedure. The goal wa…

This study tested a new drug called ACT-293987 (NS-304) in 43 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure damages the lungs. The trial had two parts: first, a single dose to check how it affects blood flow, then 21 weeks where some peo…

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This study compares cardiac MRI to the standard right heart catheterization for monitoring people with pulmonary arterial hypertension (PAH), a condition that strains the heart. Researchers want to see if the non-invasive MRI can reliably detect when a patient's condition is wors…

This study tested whether a special MRI technique called 4D flow can accurately measure blood pressure in the lungs of people with pulmonary hypertension. 28 patients had both the MRI and the standard invasive catheterization to compare results. If the MRI proves reliable, it cou…

This study tested whether metformin, a common diabetes drug, along with a text-message activity program, could help people with pulmonary artery hypertension (PAH) walk farther and feel better day-to-day. 73 adults with PAH took part. The goal was to see if these interventions im…

This study looks at whether low-resistance exercise (like light strength training) can safely help people with pulmonary arterial hypertension (PAH) feel better and be less frail. About 20 adults with stable PAH will try the program. Researchers will track safety, how well people…

This study tested a single dose of an investigational drug called RT234 in 42 adults with pulmonary arterial hypertension (PAH), a condition that makes it hard to exercise due to high blood pressure in the lungs. The main goals were to see if the drug is safe and if it improves e…

This study tested an inhaled medication called RT234 in 14 adults with pulmonary arterial hypertension (PAH), a condition where blood pressure in the lungs is dangerously high. The goal was to see if the drug could quickly lower lung blood pressure during a heart catheterization …

This study tested whether people with pulmonary vascular disease (problems with blood vessels in the lungs) can walk the same distance in 6 minutes without extra oxygen as they can with it. 40 adults who had low oxygen levels during exercise did two walk tests—one breathing norma…

This study tested whether slow-paced breathing at home can help people with pulmonary arterial hypertension (PAH) manage symptoms like shortness of breath, fatigue, and poor sleep. Forty-two adults with stable PAH took part, with one group adding slow breathing exercises to their…

This study tested whether 8 weeks of inspiratory muscle training (breathing exercises using a device) could improve exercise capacity in 32 people with pulmonary hypertension. Participants were randomly assigned to either active training or a placebo version. The goal was to see …

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This trial tests whether an Apple Watch paired with a special app can accurately measure how far people with pulmonary arterial hypertension (PAH) can walk in six minutes — both in the clinic and at home. Researchers want to see if daily home-based walk tests can detect changes i…

This study tested whether a new 3D ultrasound technique can predict how well patients with pulmonary hypertension will do. Researchers followed 150 patients for six months, collecting heart images and tracking deaths and hospitalizations. The goal was to see if this non-invasive …

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study looked at whether a special MRI scan (4D Flow) can accurately measure blood flow to the lungs in people with both congenital heart disease and pulmonary hypertension. The standard test for this is a heart catheterization, which is invasive and uncomfortable. The study …

This study tested a special MRI that uses inhaled xenon gas to take detailed pictures of lung function in people with pulmonary arterial hypertension (PAH). Ten adults with PAH had four scans over 18 weeks to see how their lungs processed the gas. The goal was to find new ways to…

This study looked at whether cardiac MRI can accurately measure right heart function in 112 people with pulmonary arterial hypertension. Researchers compared MRI results with data from invasive heart catheterization. The goal was to see if MRI could be used to monitor disease and…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This study looked at 43 adults with scleroderma or unexplained pulmonary arterial hypertension (PAH) to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over 6 months. The goal…

This completed study looked at whether a new ultrasound score called VExUS can help doctors better assess risk in people with pulmonary arterial hypertension (PAH). Researchers measured VExUS in 86 adults and compared it to standard tests like heart catheterization and blood mark…

This study tested whether a device called MYOTRACE, which measures how hard a person's breathing muscles are working, can help doctors assess patients with respiratory diseases. 56 adults with conditions like COPD or asthma were included. The goal was to see if the device's readi…

This study tested a new self-administered questionnaire called DYSLIM to measure shortness of breath and its impact on daily life in people with chronic respiratory diseases like COPD, cystic fibrosis, and pulmonary hypertension. Researchers enrolled 199 participants to check if …

This study looked at whether breathing in nitroglycerin (a medicine that opens blood vessels) is safe and effective for people with pulmonary arterial hypertension (PAH), a condition where lung blood vessels narrow. Twenty adults with PAH took part. The goal was to see if the spr…

This early-stage study looked at whether people with pulmonary arterial hypertension (PAH) have low carnitine levels and if taking carnitine supplements could help. Ten adults with PAH kept food diaries and had blood tests to measure carnitine. The goal was to gather information …

This early-phase trial tested the safety and how the body processes an inhaled form of vardenafil (RT234) in 31 healthy adults. Participants received single and multiple doses of the drug via an inhaler or as a pill. The study is complete and focused on side effects and drug leve…

This completed Phase 1 study looked at how two drugs, BIA 5-1058 and furosemide, affect each other when taken together. 44 healthy adults received each drug alone and then together, under fasting conditions. The goal was to measure drug levels and safety, not to treat any disease…

This completed study looked at 1,200 pregnant women with pulmonary hypertension (high blood pressure in the lungs) to see if long-term exposure to air pollution raises the risk of serious pregnancy complications like heart failure or death. Researchers analyzed medical records an…