Ocular growth disorder

This study tests whether new spectacle lenses can safely slow the progression of myopia (nearsightedness) in children. About 249 kids will wear either the novel lenses or standard single vision glasses for 36 months. Researchers will measure changes in eye length and prescription…

This study tests whether combining special glasses (that create optical defocus) with low-dose atropine eye drops can better control myopia (nearsightedness) in children aged 7 to 12. Over 18 months, researchers will measure changes in eye prescription and eye length. The goal is…

Researchers compare two strengths of atropine eye drops, 0.05% and 0.5%, in Dutch children aged 6 to 11 with progressive nearsightedness. About 550 children use the drops for three years, then researchers follow them for two more years. The goal is to see which strength better sl…

This study tests whether a tiny steroid-releasing implant (Dextenza) placed in the tear duct works as well as standard steroid eye drops after corneal crosslinking surgery for keratoconus. About 20 people aged 13 and older with progressive keratoconus will receive either the impl…

Researchers are studying whether the benefit of a special spectacle lens for slowing nearsightedness lasts after children stop wearing it. The trial follows 91 children who took part in an earlier three-year study, where some wore the innovative lenses and others wore regular sin…

This study tests whether pupil size changes can predict how well peripheral defocus spectacle lenses slow myopia progression in children. Researchers will measure pupil responses and track eye growth over 24 months in 14 kids with progressive myopia. The goal is to see if a simpl…

This study compares two special contact lenses (MiSight 1 Day and Abiliti 1-Day) to see which one better slows the worsening of nearsightedness in Chinese children aged 6-12 living in New Zealand. Each child will wear a different lens in each eye for 6 months. The goal is to find…

This phase 3 trial tests whether an experimental eye drop called CTO0308 can slow the progression of myopia, or nearsightedness, in children aged 5 to 12. Participants receive either the active drop or a placebo once daily in each eye for 12 months. Researchers measure changes in…

This study tests whether Essilor Stellest spectacle lenses can slow the progression of myopia (nearsightedness) in children and teens aged 6 to 16. One hundred fifty participants will wear the lenses for at least 12 hours a day over 24 months. Researchers will measure changes in …

This trial tests whether alternating two common myopia treatments—nightly ortho-k contact lenses and low-dose atropine eye drops—can slow the progression of nearsightedness in children and teens more effectively than using ortho-k lenses alone. The study will enroll 112 participa…

This study tests whether contact lenses with A.R.R.E.S.T.® technology can slow the progression of myopia (nearsightedness) in children compared to standard single-vision lenses. About 80 children aged 7 to 15 will wear either the special or standard lenses for 12 months, with sev…

This trial tests whether implanting a fresh, donated corneal lenticule — a thin layer of corneal tissue — can safely correct residual farsightedness in people who already have an artificial lens implant after cataract surgery. The procedure uses a femtosecond laser to create a po…

This case report tests whether implanting a fresh corneal lenticule from a myopic donor, along with autologous serum drops, can safely thicken the cornea and improve vision in a person with advanced keratoconus. The procedure uses a femtosecond laser to place the graft. The goal …

This trial tests whether a corneal lenticule — a thin disc of tissue taken from a donor eye during a type of laser surgery — can be implanted into the cornea of people with progressive keratoconus, a condition where the cornea thins and bulges outward. The goal is to increase cor…

This trial tests whether a laser procedure called Relex-Smile can correct leftover nearsightedness or farsightedness in people who had cataract surgery six months earlier. About 130 participants with blurry vision after receiving a trifocal lens implant will undergo the laser tre…

This study tests special glasses called D.D.C dual-control lenses to see if they can slow down worsening nearsightedness (myopia) in children aged 6 to 14. Over 24 months, 316 kids will wear either the new lenses or standard glasses. The goal is to measure changes in eye prescrip…

This trial tests three approaches to slow the progression of nearsightedness (myopia) in children aged 5 to 12: daily atropine eye drops, MiSight contact lenses, and NaturalVue multifocal contact lenses. Over two years, researchers will measure changes in eye length and prescript…

This study tests whether special spectacle lenses called DIMS (defocus incorporated multiple segment) can slow the progression of nearsightedness (myopia) in university students aged 18 to 23. Participants wear either the DIMS lenses or standard single-vision glasses for comparis…

This study tests whether taking branched-chain amino acid (BCAA) supplements for six months can slow the progression of myopia (nearsightedness) in young adults aged 18 to 25. Participants either receive BCAA supplements plus standard glasses or a placebo plus glasses. The goal i…

This trial tests whether special spectacle lenses called Diffusion Optics Technology (DOT) lenses can slow the progression of nearsightedness (myopia) in Chinese children aged 6 to 13. Over 12 months, 195 children will wear either the DOT lenses or standard single-vision lenses. …

This study tests whether MiSight 1 Day contact lenses can slow the progression of myopia (nearsightedness) in children aged 8 to 12. Participants wear either MiSight 1 Day or standard Proclear 1 day lenses for three years, then all switch to Proclear for one year to see if the ef…

This study looks at the safety of MiSight 1 Day contact lenses in children aged 8 to 12 with nearsightedness (myopia). Participants wear the lenses daily for three years, and researchers track eye infections and other problems. The goal is to confirm that these lenses are safe fo…

This early-stage study is testing whether a specially prepared membrane made from donated human tissue can help heal chronic wounds, like diabetic foot ulcers and eye surface injuries. The membrane is sterilized with different doses of radiation to find the best balance between s…

This study tests whether dual focus contact lenses (MiSight) can slow the progression of nearsightedness (myopia) in university students aged 18 to 21. Participants wear either the test lenses or standard single vision lenses for at least 10 hours a day. Researchers measure chang…

This study compares two common laser eye surgeries—KLEx and FS-LASIK—for treating nearsightedness and astigmatism. Researchers will follow 80 adults aged 21 and older to see which procedure provides better vision without glasses and has fewer side effects. Both surgeries reshape …

This study tests two types of eyeglass lenses designed to slow the progression of nearsightedness (myopia) in children aged 6 to 13. Over 6 months, researchers will measure changes in eye length and thickness to see how the lenses affect eye growth. The goal is to find a better w…

This registry collects long-term data from hundreds of people in Germany who have undergone corneal cross linking for keratoconus, a condition where the cornea thins and bulges, causing vision loss. The procedure uses riboflavin (vitamin B2) eye drops and UV light to stiffen the …

This study compares two types of contact lenses for slowing myopia (nearsightedness) in children aged 8 to 14. Over three years, researchers will measure changes in eye length and vision to see if the new lens works as well as the existing one. The goal is to help kids maintain b…

This study tests special spectacle films designed to slow down myopia (nearsightedness) in children. About 210 kids aged 6 to 14 are taking part. The films use a new technology called S.T.O.P.® that creates changing visual cues, which may help control how fast the eye grows and p…

This pilot study tests whether combining low-dose atropine eye drops (0.01% or 0.025%) with ear acupressure can safely slow myopia progression in 420 children aged 6-12. Participants are randomly assigned to one of six groups, including placebo, and are followed for 12 weeks. The…

This study tests a new type of eyeglass lens designed to slow down nearsightedness (myopia) in children. Fifty kids aged 6 to 15 will wear the special lenses for six months. Researchers will measure changes in the eye's thickness and length to see if the lens works and is safe.

This study tests whether eye pressure-lowering medication can slow the progression of severe nearsightedness (high myopia) in adults. Researchers will measure changes in eye length and vision over time. The trial includes 152 participants aged 18 to 65 with worsening high myopia …

This study tests whether a special film applied to glasses can slow the progression of nearsightedness (myopia) in children aged 6 to 14. The film uses A.R.R.E.S.T.® technology, which is designed to send specific light signals to the eye to control its growth. Over two years, res…

This study tests whether special glasses with P.A.U.S.E. technology can slow the progression of nearsightedness (myopia) in children. About 205 Vietnamese children aged 6-14 will wear either the special lenses or regular glasses for one year, then all will wear the special lenses…

This phase 3 trial tests a procedure called corneal collagen crosslinking for people with progressive keratoconus, a condition where the cornea thins and bulges, blurring vision. The treatment uses riboflavin (vitamin B2) drops and UV light to stiffen the cornea. The study aims t…

This study tests special glasses with Diffusion Optics Technology to see if they can slow the progression of nearsightedness (myopia) in children. About 200 kids who completed a previous study will wear these glasses for up to 3 years. Researchers will measure changes in eye leng…

This 3-year study tests whether a new type of spectacle lens can slow the progression of nearsightedness (myopia) in children aged 6 to 10. A total of 266 kids will wear either the novel lenses or standard lenses, and researchers will measure changes in eye length and prescriptio…

This study tests whether special new spectacle lenses can slow the worsening of nearsightedness (myopia) in children. About 342 kids aged 7 to 13 will wear either the new lenses or standard single-vision glasses for one year, then all switch to the new lenses for another year. Th…

This study tests a new type of spectacle lens (DG2) designed to slow down nearsightedness (myopia) in children whose vision is getting worse quickly. 118 children aged 4–13 will wear these lenses for 4 years. Researchers will measure changes in their eye prescription and eye leng…

This study tests two types of special glasses (DIMS and D2 lenses) to see if they can slow down worsening nearsightedness in children whose vision is getting worse quickly. About 59 children will wear these glasses for 4 years, and researchers will measure changes in their eyesig…

This study tests whether a new surgical guide (the Alfonso nomogram) helps doctors place corneal ring implants more effectively in people with moderate keratoconus. Twenty-five adults aged 18–35 with progressive disease received the implant. Researchers will measure changes in vi…

This study tests whether specially designed eyeglass lenses can slow the progression of myopia (nearsightedness) in children aged 6 to 14. Researchers will measure changes in eye length and prescription over time, while also checking for safety and comfort. The goal is to find a …

This study tests a new surgical technique to close macular holes in people with high myopia without using a gas bubble. The standard approach requires a gas bubble that blurs vision and forces patients to keep their head down for days. The new method uses a gel-like substance to …

This study tests whether a special lens called Blue Star MAX-5 can slow the progression of nearsightedness (myopia) in children aged 8 to 11. Two hundred kids will wear either the new lens or standard glasses and be checked every six months for two years. The goal is to see if th…

This study tests whether Essilor Stellest spectacle lenses can slow the progression of nearsightedness (myopia) in adults aged 18 to 40. Each participant wears a Stellest lens in one eye and a standard lens in the other, allowing direct comparison. The trial measures changes in e…

This early study tests whether TN-001 eye drops are safe and can stop keratoconus, a disease that thins and bulges the cornea, from getting worse. About 20 adults with progressive keratoconus will use the drops twice daily for 3-6 weeks. Researchers will monitor for side effects …

This study tracks 75 nearsighted young adults over 12 months to see how low-dose atropine eye drops or soft multifocal contact lenses affect the shape of the eye. Participants are randomly assigned to one of these treatments or no treatment. Researchers will take eye photos and m…

This study tests a new eye drop called SHJ002 to see if it can safely slow down worsening nearsightedness (myopia) in children ages 3 to 12. The drop works by targeting a specific molecule in the eye. Researchers will compare it to a standard treatment, atropine, and measure chan…

This study tests special 3D-designed defocus lenses to see if they can slow down myopia (nearsightedness) in children aged 6 to 14. The lenses are meant to control how the eye grows, reducing the need for stronger glasses over time. Researchers will track changes in vision and ey…

This study tests whether special open-ring spectacle lenses can slow the progression of nearsightedness (myopia) in Chinese children aged 6 to 12. A total of 180 children will wear one of three lens designs for 12 months, with some continuing for another year. The goal is to see …

This study tests whether special glasses with a double helix lens design can slow the progression of myopia (nearsightedness) in children and adolescents aged 6 to 13. About 236 participants will wear either the new glasses or standard single-vision glasses for over 10 hours a da…

This phase 2 trial tests whether adding a new antibody called HLX22 to standard treatment (trastuzumab plus chemotherapy) can shrink tumors and improve survival in people with HER2-positive pancreatic cancer that has spread. The study enrolls 45 adults who have not had prior trea…

This study looks at how removing a pterygium (a fleshy growth on the eye) and replacing it with a small piece of the patient's own eye tissue changes the shape of the cornea. Researchers will measure the cornea's curve before and one month after surgery in 130 adults aged 30 to 7…

This Phase 3 trial tests CBT-001 eye drops against a placebo in 660 people with pterygium, a non-cancerous growth on the eye's surface. The goal is to see if the drops can reduce redness and stop the growth from getting bigger over 24 months. If successful, it could offer a drug-…

This study tests whether NaturalVue multifocal contact lenses can slow the progression of myopia (nearsightedness) in children aged 7 to 12. Over three years, 144 kids will wear either standard single-vision lenses or the multifocal lenses. Researchers will measure changes in the…

This study tests whether combining low-dose atropine eye drops with special glasses (DIMS lenses) can slow the worsening of nearsightedness in children better than atropine alone. About 111 kids aged 4–16 with progressing myopia will be randomly assigned to one of two groups. The…

This study compares a new AI system, called AEYE, against a human eye doctor in diagnosing keratoconus and deciding who is eligible for laser vision correction. The AI analyzes patient history, eye scans, and other data to make its recommendations. Researchers will check if the A…

This trial tests whether giving free glasses to short-sighted middle school children in rural China helps more of them continue to academic high school. Researchers will randomly assign 111 schools to either provide glasses with teacher support or just give prescriptions. The mai…

This study tests whether taking vitamin B2 (riboflavin) daily and spending time outdoors in sunlight can slow the progression of myopia (nearsightedness) in children aged 6 to 12. Participants will be randomly assigned to receive different doses of riboflavin or a placebo, and al…

This trial tests whether providing free corrective glasses to young motorcycle drivers with myopia (nearsightedness) can reduce the number of crashes and near-misses. Participants are university students in Ho Chi Minh City who drive regularly and have uncorrected or under-correc…

This study tests whether special 'peripheral focus-out' glasses can prevent nearsightedness (myopia) in Chinese children aged 6 to 8. Over two years, 160 children will wear the glasses at least 8 hours a day. Researchers will measure changes in their vision to see if the glasses …

This study tests whether special glasses can prevent nearsightedness (myopia) in children aged 6 to 9 who are not yet nearsighted but are at risk. About 388 children will wear the glasses for at least 8 hours a day for one year. Researchers will track how many children become nea…

This study looks at whether using a special red light device twice a day can help prevent or control nearsightedness (myopia) in children aged 5 to 16. Researchers are following 3,000 kids who have used the therapy for at least a year, some for up to three years or more. The goal…

This trial tests whether Relex-Smile laser surgery can safely and effectively correct residual nearsightedness in people who still have blurry distance vision six months after cataract surgery. Participants will undergo the laser procedure and have their vision and refraction mea…

This expanded access program gives seriously ill adults with advanced pancreatic cancer and cachexia (severe weight loss and muscle wasting) access to the experimental drug mifomelatide. Patients receive a daily injection for up to 13 weeks. The goal is to provide a potential tre…

This study compares two methods of removing the outer layer of the cornea during PRK laser eye surgery. One method uses a laser to remove the layer, while the other uses a manual tool. The goal is to see which approach leads to better vision and faster healing. About 100 people a…

This study compares how well two types of daily disposable multifocal contact lenses work for people with nearsightedness (myopia). Researchers will measure things like sharpness of vision, reading ability, and eye coordination. About 30 people aged 9 to 30 who already wear conta…

This study tests whether a software program called the Vision Trainer can guide eyeglass prescriptions as accurately as the traditional manual method performed by trained examiners. Adults with myopia (nearsightedness) will have their prescriptions determined both ways, and the r…

This study examines protein differences in the tears of nearsighted children who use special overnight contact lenses (orthokeratology) to slow down worsening vision. Researchers want to understand why some children get better control of their myopia than others. The study involv…

This study looks at how a new type of eyeglass lens affects the back layer of the eye (the choroid) in children with worsening nearsightedness. Ten children already in a larger study will have their eye thickness measured with a special camera. The goal is to understand if the le…

This study looks at how well children with nearsightedness (myopia) see when wearing special glasses. The 51 participants are already part of a larger study on myopia progression. Researchers will measure reading speed and vision in different lighting to see how the lenses perfor…

This study follows 90 children who previously wore special spectacle lenses to slow nearsightedness (myopia). After stopping the lenses, researchers measure how much their vision changes over 12 months. The goal is to see if the benefits of the lenses last after use ends.

This study looks at how the eye focuses (lag of accommodation) when children with nearsightedness wear special DOT pattern spectacle lenses compared to regular glasses. About 30 kids aged 6 to 18 will have their vision measured at distance and close-up with each lens type. The go…

This study tests whether special spectacle lenses called Diffusion Optics Technology (DOT) lenses can change the thickness of the choroid, a layer of blood vessels in the eye. Researchers will measure these changes in 30 children aged 8-14 with normal vision after wearing the len…

This study uses artificial intelligence to predict true eye pressure after corneal refractive surgery like LASIK or SMILE. Standard eye pressure measurements can be falsely low after these surgeries, masking glaucoma risk. Researchers will analyze data from over 10,000 participan…

This study looks at how keratoconus, a disease that thins and bulges the cornea, affects electrical signals in the eye and brain. Researchers will measure these signals in 50 adults with different stages of keratoconus using standard eye tests. The goal is to see if these measure…

This study uses a special light-based technique called Brillouin microscopy to measure the stiffness of the cornea in people with keratoconus, a condition where the cornea thins and bulges. Researchers will compare measurements before and after treatments like corneal cross-linki…

This study reviewed records of 70,000 adults who had non-urinary surgery under general anesthesia. It compared two drugs used to reverse muscle relaxants: sugammadex and neostigmine (given with atropine or glycopyrrolate). The goal was to see which drug is linked to fewer cases o…