Can special lenses plus eye drops stop Kids' myopia from getting worse?
NCT ID NCT06358755
First seen Jun 27, 2026 · Last updated Sep 18, 2026 · Updated 2 times
Summary
This study tests whether combining special glasses (that create optical defocus) with low-dose atropine eye drops can better control myopia (nearsightedness) in children aged 7 to 12. Over 18 months, researchers will measure changes in eye prescription and eye length. The goal is to find a more effective way to slow myopia progression.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- low-dose atropine (0.01%) eye drops
- What this could lead to
- If successful, this combination approach could offer a more effective way to slow down worsening nearsightedness in children, potentially reducing the need for stronger glasses later.
- What could go wrong
- This is a relatively small, early-stage trial (112 children) and results may not apply to all ethnicities or ages. The atropine drops can cause side effects like light sensitivity or blurred near vision.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 112 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2024
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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7 to 12 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age at enrollment: 7 to 12 years * Ethnicity: Hong Kong Chinese * Myopia: -0.75D (in spherical equivalent) or above in both eyes * Astigmatism: -1.50D or less in both eyes * Anisometropia: 1.50D or less (in spherical equivalent) between two eyes * Best corrected monocular visual acuity (VA): 0.04 logMAR or better * Ocular health: No abnormalities in both internal and external ocular health * Systemic health: No abnormalities such as cardiac and respiratory diseases * Binocular vision: No strabismus, diplopia, suppression and other binocular abnormalities * Normal colour vision * No previous refractive surgery or use of myopic control interventions, such as atropine, orthokeratology, and specialized spectacle lenses and contact lenses for myopic control * Able to wear the prescribed spectacles * No known allergy to atropine Exclusion Criteria: * Eye disease or binocular vision problems (e.g., strabismus, amblyopia, oculomotor nerve palsies, corneal disease, etc.) * Previous intraocular or corneal surgery * Colour vision deficiencies * Systemic disease that may affect vision, vision development (e.g. diabetes mellitus, hypertension, Down syndrome, etc.) * Systemic disease that are contradictory to atropine (e.g. asthma, cardiac diseases, etc.) * Previous gas permeable, soft bifocal, or orthokeratology contact lenses wear or bifocal / progressive addition lens spectacles wear or use of atropine or pirenzepine (longer than one month of usage) * Previous or current participation in myopia control studies * Allergy to cyclopentolate hydrochloride or atropine
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre for Myopia Research, The Hong Kong Polytechnic University and Department of Ophthalmology, The University of Hong Kong
Hong Kong, No postcode, Hong Kong
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Other studies related to the condition(s) this trial covers.
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