Metastatic malignant neoplasm in the brain

Researchers are testing whether adding AGuIX, a gadolinium-based nanoparticle, to whole brain radiation therapy improves how well brain metastases shrink in adults whose cancer has spread to the brain. Participants receive standard whole brain radiation, and some also receive thr…

Researchers are testing whether adding brain radiotherapy to PD-1/PD-L1 inhibitors and chemotherapy helps people with untreated stage IV non-small cell lung cancer that has spread to the brain. The trial enrolls about 40 adults whose tumors lack common driver mutations and whose …

This study tested giving focused radiation before surgery to people with cancer that spread to the brain. The goal was to see if this approach is safe and might lower the chance of the tumor coming back. 26 adults with brain metastases took part. The treatment aims to control the…

This phase I trial tested a special type of radiation called hypofractionated radiosurgery for people with large brain metastases (tumors that spread from other cancers). The goal was to find the safest and most effective dose while limiting damage to healthy brain tissue. Twenty…

This phase 2 trial tested whether adding the drug veliparib to standard chemotherapy (cisplatin) helps people with metastatic triple-negative or BRCA-related breast cancer, including those with brain metastases. The study enrolled 344 participants to see if the combination slows …

This early study tested whether giving a single dose of nivolumab with either ipilimumab or relatlimab before surgery is safe and possible for people with melanoma that has spread to the brain. Only one person took part, so results are very limited. The goal was to see how the dr…

This pilot study tested whether giving gamma knife radiation before surgery for brain metastases is safe and feasible. Eleven adults with 1 to 4 brain tumors took part. The goal was to see how many patients could have surgery after radiation and how many had no visible tumor left…

This study tested whether a device that uses focused ultrasound can safely and temporarily open the blood-brain barrier in people with HER2-positive breast cancer that has spread to the brain. Eight participants received the procedure, and researchers checked for side effects and…

This early study tested combining the immunotherapy drug pembrolizumab with precise radiation (stereotactic radiosurgery) in 25 people with melanoma or lung cancer that had spread to the brain. The main goal was to check for serious side effects. Researchers also tracked how long…

This study tested a new approach for people with large brain metastases (tumors that spread from other cancers). Instead of the usual surgery followed by radiation, patients received focused radiation first, then surgery. The goal was to see if this order reduces side effects and…

This study tested a precise type of radiation called fractionated stereotactic radiotherapy (FSRT) in 33 adults with 1 to 4 small brain metastases (each 2 cm or smaller). The goal was to see if this approach could control the tumors while avoiding serious side effects like radiat…

This study tested a combination of two immunotherapy drugs, low-dose ipilimumab and pembrolizumab, in 24 people with advanced melanoma that had spread to the brain. The goal was to see if the treatment could shrink or control brain tumors and improve survival. Participants receiv…

This phase 2 trial tested the drug furmonertinib in 24 people with advanced non-small cell lung cancer (NSCLC) that has EGFR mutations and spread to the brain. The goal was to see how long the drug could keep brain tumors from growing. Participants took a daily pill, and research…

This early-phase study tested whether combining stereotactic radiosurgery (precise radiation) with the immunotherapy drug nivolumab (Opdivo) is safe and can shrink tumors in people with breast cancer that has spread to the brain. Fourteen participants received the combination. Th…

This study tested giving a precise, high-dose radiation treatment (stereotactic radiosurgery) to brain metastases before surgical removal. The goal was to see if this approach improves local control at 6 months. The trial enrolled 70 adults with up to 4 brain metastases from cert…

This study tested whether giving higher doses of radiation over five sessions is safe for people with brain metastases that are 2 to 6 cm in size. These larger tumors are often too risky for a single high-dose treatment. The trial enrolled 13 adults and aimed to find the highest …

This study tested whether a portable device that creates low-intensity electric fields (called Tumor Treating Fields, or TTFields) can help control brain tumors that have spread from non-small cell lung cancer. 298 adults with 1 to 10 brain metastases received standard radiosurge…

This early-phase trial tested a four-drug combination (entinostat, atezolizumab, carboplatin, and etoposide) in 3 people with extensive-stage small cell lung cancer that had not been treated before. The goal was to find a safe dose and see if the combination could be given for at…

This study tested a new drug called AZD3759 against standard targeted therapies (erlotinib or gefitinib) in 492 people with advanced EGFR-mutant lung cancer that had spread to the brain. The goal was to see if AZD3759, which is designed to better reach the brain, could keep the c…

Researchers at Lund University Hospital are testing a new MRI technique called DIVIDE to see if it can measure how sensitive brain metastases are to radiation. Today, doctors only see whether radiation worked by watching tumor size change on scans weeks or months later. This tria…

This completed study tested whether a special type of MRI called dynamic susceptibility contrast (DSC) perfusion MRI can accurately tell the difference between radiation-induced brain damage and tumor regrowth in people whose cancer has spread to the brain. Eight patients who had…

This study looked at 30 adults with lung cancer that had spread to the brain. Researchers compared two standard MRI sequences (T1 and T2*) to see which one better detects and tracks brain metastases after chemotherapy or targeted therapy. The goal is to improve diagnosis and moni…

This study tested a special PET scan tracer called FLT in 50 adults with brain tumors (gliomas or metastases). The goal was to see if FLT-PET can measure how fast tumor cells are growing, which could help doctors diagnose and predict tumor behavior better than current scans like …

This study tested whether a special PET scan (called 18F-DOPA PET-CT) can find brain metastases as well as or better than standard MRI in people with lung cancer, breast cancer, or melanoma. 32 adults with untreated brain metastases took part. The goal was to see if this PET meth…

This study tested a new MRI contrast agent called RVP-001, made with manganese instead of gadolinium, in 18 adults with known brain lesions (like tumors or multiple sclerosis). The goal was to see if it is safe and can detect lesions as well as current gadolinium-based dyes. Each…

This study tested whether an early, quick PET scan using F-DOPA can help doctors tell the difference between a brain tumor coming back and damage from radiation therapy. Eight patients who already needed a PET scan for their brain metastases took part. The goal was to see if meas…

Whole-brain radiotherapy is a common treatment for cancer that has spread to the brain, but it often harms memory and thinking. This phase III trial tests whether adding the drug memantine and using a radiation technique that avoids the hippocampus, a brain area key to memory, ca…

This study tested a therapy called Managing Cancer and Living Meaningfully (CALM) to see if it helps people with brain cancer feel less distressed. 60 adults with brain tumors or brain metastases who had high depression or death anxiety took part. The study measured how many peop…

This study looked at whether standard radiation treatment for cancer that has spread to the brain causes changes in thinking skills like memory and attention. 35 adults with brain metastases received radiation and took tests and surveys before and after treatment. The goal was to…

This study tests whether a surface-guided system called AlignRT can position patients more accurately during stereotactic radiosurgery for brain metastases compared to standard manual methods. Twenty adults each had their position checked twice—once manually and once with AlignRT…

This study compared two types of radiation for people with 11 to 20 brain tumors that spread from other cancers. One group got Gamma Knife radiosurgery, which targets each tumor precisely. The other got whole brain radiation, which treats the entire brain. The goal was to see whi…

This study analyzed health records from over 229,000 people with newly diagnosed lung cancer in Korea to see if getting a brain MRI every year helps find cancer that has spread to the brain. The goal was to learn whether these scans catch brain metastases earlier, when they might…

This study looked at medical records of 938 adults with solid tumors who received immunotherapy. Researchers compared how well the treatment worked when cancer had spread to different organs like the liver, brain, lung, or bone. The goal is to understand why some metastatic sites…

This completed study from Mayo Clinic interviewed 33 adults with brain or central nervous system (CNS) tumors, along with their caregivers, to learn about their biggest challenges and needs. The goal was to identify areas where doctors and healthcare teams can offer better suppor…

This study examined genetic and epigenetic changes in brain metastases from solid cancers. Researchers collected tumor tissue, blood, and spinal fluid from 21 patients during surgery to compare molecular profiles. The goal was to see if liquid biopsies could reliably reflect the …

This study looked back at medical records of 300 people with EGFR-positive non-small cell lung cancer that had spread to the brain or spinal cord. All patients were treated with the drug firmonertinib. Researchers analyzed how long the drug controlled brain tumors and explored wh…

This completed study gathered information from nearly 1,000 patients who received or were scheduled to receive HyperArc stereotactic radiosurgery, a precise radiation treatment for brain tumors. The goal was to collect data on survival and tumor control to compare HyperArc with o…