Lung disorder

This Phase 3 trial tests an updated COVID-19 vaccine (BNT162b2, 2025/2026 formulation) in 343 children aged 5 to 11 who have medical conditions that put them at high risk for severe COVID-19. All participants receive one dose and are monitored for about 6 months to check safety a…

This trial tests a system that evaluates donor lungs outside the body to see if they are suitable for transplant. The goal is to increase the number of lungs available for people with severe, life-limiting lung disease who are waiting for a transplant. Participants are adults alr…

This phase II trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation can help people with stage III non-small cell lung cancer that cannot be surgically removed. About 50 participants will receive the combination treatment, and …

This phase 3 trial tested a new triple-combination inhaler (beclometasone, formoterol, and glycopyrrolate) against a standard two-drug inhaler in 1,368 adults with severe COPD. The study measured changes in lung function and breathlessness over 52 weeks. The goal was to see if th…

This study tested whether video-based medication coaching helps adolescents and young adults with uncontrolled asthma take their inhaled steroids more regularly. 375 participants received either standard care or telehealth sessions to improve medication use. The goal was to see i…

This study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if rali…

This study tested a device called the Toronto EVLP System that keeps donated lungs warm and breathing outside the body. The goal was to see if it is safe to extend the time doctors can preserve and check the lungs before transplant. 118 adults waiting for a lung transplant took p…

This study tested a new drug called verekitug (UPB-101) in 479 adults with severe asthma. The goal was to see if it could reduce asthma attacks and improve lung function compared to a placebo. Participants received either verekitug or a dummy injection over several months. The tr…

This study followed 212 adults with moderate to severe COPD in Greece who were prescribed a triple-combination inhaler (Trixeo Aerosphere). Researchers tracked why patients switched from dual therapy and how their symptoms and quality of life changed over 52 weeks. The goal was t…

This study followed 250 adults with COPD who were starting a new triple-combination inhaler (budesonide/glycopyrronium/formoterol, or BGF) in routine Italian clinics. Researchers measured how patients felt about their health after 12 weeks and up to a year. The goal was to see re…

This phase 2 trial tested a combination of two oral drugs, RMC-4630 and sotorasib, in 47 adults with advanced KRASG12C-mutant non-small cell lung cancer that had progressed after standard treatments. The goal was to see if the combination could shrink tumors. The study is now com…

This study tested a new way to give Alpha-1 protein therapy by injecting it under the skin instead of into a vein. Seventeen adults with Alpha-1 Antitrypsin Deficiency received either a low or high dose weekly for eight weeks. The main goal was to check safety and how the drug mo…

This study tested an experimental oral drug called INS018_055 in 71 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and makes breathing hard. The main goal was to see if the drug is safe and tolerable over 12 weeks compared to a placebo. Resea…

This study tested an experimental drug called SPR720 in 25 adults with a chronic lung infection caused by Mycobacterium avium complex (MAC). The goal was to see if the drug can reduce bacteria in sputum and is safe compared to a placebo. Participants took the drug or placebo by m…

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This study tested whether taking vitamin D every day could reduce lung complications in children and teens with sickle cell disease. Lung problems like infections, asthma attacks, and acute chest syndrome are major causes of illness and death in this condition. Researchers gave d…

This study tested whether a salmon oil supplement called CARDIO® could help control asthma in adults. 70 participants took either the supplement or a placebo alongside their usual asthma medications. The goal was to see if the supplement reduced asthma attacks and improved breath…

This study tested whether adding a digital remote monitoring system to a standard pulmonary rehabilitation program helps people with COPD. 78 participants either received the enhanced program with daily vital sign tracking or the standard program alone. The main goal was to see i…

This study tests whether an enhanced diagnostic workup can identify lung diseases other than tuberculosis in patients who are about to start TB treatment based on clinical signs but have negative sputum tests. Participants will undergo a thorough review and possibly additional te…

This trial tests whether an ultra-low-dose CT scan, using a new image reconstruction algorithm, can produce images good enough for diagnosing lung, abdominal-pelvic, and bone lesions, compared to a standard-dose CT scan. About 116 adults will receive both scans as part of their u…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This study tested whether a simple checklist and blood test (the YEARS algorithm) can safely rule out pulmonary embolism (a blood clot in the lungs) in people with active cancer, compared to the standard approach of doing a CT scan on everyone. About 700 cancer patients with susp…

This study tested whether giving doctors access to a blood test called FirstLook increases lung cancer screening rates among people at high risk. The test looks for DNA fragments in the blood that may signal lung cancer. Researchers compared screening rates in practices that coul…

This study tested a new MRI technique that can take pictures of children's lungs without using radiation or injecting contrast dye. 72 children aged 6-16 had both a standard CT scan and this new MRI. The goal was to see if the MRI could produce clear images of the lungs, potentia…

This study looked at whether giving warm, moist oxygen through a tracheostomy tube can prevent lung complications like pneumonia or collapsed lungs after major head and neck surgery. 56 adults who had surgery with a tracheostomy were randomly assigned to receive either this high-…

Researchers compare two ultrasound-guided nerve blocks to see which one better controls pain after video-assisted thoracoscopic surgery (VATS), a minimally invasive lung operation. The trial enrolls 46 adults scheduled for VATS. Participants receive either a serratus posterior su…

This study looked at whether an 8-week Pilates exercise program could improve breathing in overweight and obese women. 54 women were split into an exercise group and a control group. The exercises focused on core strength and abdominal endurance. Researchers measured lung functio…

This study tested a single dose of a new albuterol inhaler called PT007 in 118 adults with asthma. Researchers compared how well it opened airways and its safety against a placebo inhaler and the standard Ventolin inhaler. The goal is to see if PT007 works as a quick-relief treat…

This trial tests three methods to prepare children aged 6–12 for a pulmonary function test (spirometry): routine verbal instruction, verbal instruction with a live demonstration, or watching an animation. The goal is to see which approach helps children perform the breathing mane…

This study tests whether using a mobile breathing trainer (AiroFit PRO™) for 6 weeks can improve lung function, muscle strength, and quality of life in people with hemiplegia (paralysis on one side) after a stroke. 54 adults who are at least 3 months post-stroke will be randomly …

This pilot study tested whether a smartphone-based program could help high-risk patients recover their breathing after lung surgery. Fifty-eight adults who had lung resection and were either older or had reduced lung function were split into two groups: one used a smartphone app …

This study tested whether a personalized home respiratory rehabilitation program is feasible for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants completed a 3-month program with one supervised session followed by home exercises. The …

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach…

This study tested whether giving a small amount of s-ketamine during chest surgery could reduce the risk of postoperative delirium (sudden confusion) in patients aged 60 and older. Over 500 participants were randomly assigned to receive either s-ketamine or another drug (dexmedet…

This study tested freezing the nerves between the ribs during robot-assisted lung surgery to see if it reduces pain and the need for painkillers afterward. 33 adults having lung surgery were randomly assigned to get the nerve freeze or standard pain medicine. Researchers tracked …

This study tested an inhaled medication called RT234 in 14 adults with pulmonary arterial hypertension (PAH), a condition where blood pressure in the lungs is dangerously high. The goal was to see if the drug could quickly lower lung blood pressure during a heart catheterization …

This study tested whether using a special high-flow oxygen device during exercise training helps people with COPD breathe easier and exercise more. Thirty patients completed 12 rehab sessions, and those using the device could walk at a steeper incline on the treadmill. The approa…

This study tested whether giving lidocaine or alfentanil before inserting a bronchoscope can reduce coughing when spraying numbing medicine into the airways. 108 adults with lung tumors received one of these drugs or a placebo before the procedure. Researchers measured cough seve…

This study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …

This study looked at whether taking oral corticosteroids (prednisone) for 5 days can help people with COPD who are having a flare-up. The trial involved 189 adults aged 40 and older who were treated in general practice. Researchers tracked treatment failure, including emergency v…

Bronchoscopy lets doctors look inside the airways to diagnose and treat lung diseases, and deep sedation can make the procedure more comfortable and efficient. Deep sedation also carries risks, including low oxygen levels and airway blockage. This study observes whether giving a …

This study looks at how different types of tuberculosis affect lung function and physical capacity in teenagers who have recovered from the disease. Researchers will measure lung function with a breathing test and walking ability with a 6-minute walk test in 20 adolescents aged 1…

This study looked at whether new computer methods can create higher-resolution images from a standard CT scan. Researchers compared the quality of regular CT images with enhanced versions from the same scan. 148 adults scheduled for a CT scan participated. The goal was to see if …

This study tests whether a software tool called Synapse Medicine can help hospital pharmacists who work with medical teams make better and faster medication recommendations. The tool analyzes each patient's health information to flag potential drug-related risks, such as harmful …

This study compares two breathing techniques used during robotic bronchoscopy, a procedure to biopsy lung nodules. The goal is to see which method better prevents atelectasis (lung collapse) during the procedure. About 62 adults with suspicious lung nodules will be randomly assig…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study looks at how lung ultrasound can help find lung issues early in women who are critically ill due to pregnancy complications or gynecologic cancer. Researchers will check for different lung ultrasound patterns and see if they relate to patient outcomes like death or nee…

This study looked at a new method to find out if diuretics (water pills) help individual premature babies with a chronic lung condition called bronchopulmonary dysplasia (BPD). Researchers enrolled 19 very premature infants and used a special 'N-of-1' approach, where each baby wa…

This study looked at immune cells called alveolar macrophages in the lungs of 18 people with non-infectious lung diseases. Researchers used a technique called flow cytometry to study the surface proteins on these cells. The goal was to better understand the role of these cells in…

This study looked at whether using a bedside ultrasound device to measure blood clotting can reduce the amount of blood products given during double-lung transplantation. The trial involved 128 adult patients. The goal was to see if this quick test helps doctors make better decis…

This study looked at how to best set a breathing machine during lung surgery when only one lung is being used. The goal was to see if using smaller breaths with higher pressure could keep oxygen levels stable. 88 adults having lung surgery took part. The study measured oxygen in …

This study looked at 93 people with lung disease who get short of breath when active. Participants did two 6-minute walk tests: one at their fastest pace and one at their normal walking speed. The goal was to see if the normal-speed test gives a more accurate picture of when they…

This study tested a new navigation device called AirWaze, designed to help doctors perform lung biopsies using CT scans. 37 adults with lung lesions underwent a bronchoscopy procedure with the device. The main goals were to see if the device was easy to use and if it could accura…

This study looked at 72 adults with cystic fibrosis to see if chemical changes in DNA, called methylation, are linked to how well their lungs work. The goal was to understand why lung disease gets worse at different rates in different people. No treatment was given; instead, rese…

This completed study from Johns Hopkins University compared two methods for taking lung tissue samples during a bronchoscopy: a 1.1mm cryoprobe (which freezes tissue) versus standard 2.0mm forceps (which grab tissue). The trial enrolled 500 adults scheduled for a lung biopsy and …

This study aims to find DNA markers (epigenetic biomarkers) in sputum that can predict how severe lung disease will become in people with cystic fibrosis. Researchers will collect sputum samples from 50 participants aged 12 to 30 over 18 months and analyze changes in DNA methylat…

This study tested a new device called Neola® that monitors the lungs of newborn babies. Ten preterm and term infants were enrolled to see if the device is safe and works well. The main goal was to check for any skin reactions or other side effects.

This study looked at whether a person's blood group antigens are linked to asthma attacks. Researchers followed 126 people with asthma to see if certain blood types had more flare-ups requiring steroids. The goal was to understand, not treat, the disease.

This study looked at whether people with cystic fibrosis (CF) have COVID-19 antibodies from infection or vaccination. Researchers followed 152 adults and children with CF for two years, taking blood samples every six months. They aimed to understand how many had antibodies, how l…

This study looked at 622 veterans with chronic lung disease who had COVID-19. Researchers tracked their health outcomes, recovery, and need for rehabilitation services. The goal was to understand which factors lead to more severe illness and what support patients need after recov…

This completed study looked at 102 adults undergoing a lung biopsy (EBUS-TBNA) under general anesthesia. Researchers compared two drugs—propofol (given through a vein) and sevoflurane (inhaled as a gas)—to see which one keeps the heart and blood pressure more stable and makes the…

This study tested a special MRI technique called Ultra Short Echo Time (UTE) to see if it can take clearer pictures of the lungs than traditional MRI. Researchers collected images and health information from people with and without lung disease to help doctors better understand l…

This completed study looked at 170 smokers with COPD to understand how lung damage affects brain structure and thinking skills. Participants took memory and thinking tests, had lung function tests, and underwent brain scans. The goal was to find early clues that could one day lea…

This study tested whether having a dietitian help patients with lung disease order meals during a hospital stay could improve their nutrition and reduce the chance of being readmitted after discharge. 41 patients at nutritional risk took part. Researchers measured daily food inta…

This early-stage study tested a new drug called AZD8965 in 147 healthy adults, including Japanese and Chinese participants. The main goal was to check if the drug is safe and how the body processes it, both with and without food. No treatment was given for any disease, so this st…

This study looked at whether doing synchronized breathing exercises along with aerobic exercise can improve lung function more than aerobic exercise alone. Researchers divided 45 healthy university students into three groups: one did aerobic exercise, one did both breathing and a…

This study looked at whether firefighters have different lung scan results compared to non-firefighters, and if a blood test can help better predict lung cancer risk. Over 700 current and retired firefighters took part. The goal was to improve early detection of lung cancer and o…

This completed study followed 332 adults who were hospitalized with severe COVID-19 pneumonia and needed oxygen. Researchers used CT scans and breathing tests to check for lasting lung damage. The goal was to understand how the lungs recover after a serious infection.

This early-stage study looked at whether people with pulmonary arterial hypertension (PAH) have low carnitine levels and if taking carnitine supplements could help. Ten adults with PAH kept food diaries and had blood tests to measure carnitine. The goal was to gather information …

This study reviewed medical records of 59 adults with COPD to see if a standard pulmonary rehabilitation program is safe and effective for those who also have pulmonary hypertension (high blood pressure in the lungs). Researchers compared how much walking distance improved in peo…

This early-phase trial tested the safety and how the body processes an inhaled form of vardenafil (RT234) in 31 healthy adults. Participants received single and multiple doses of the drug via an inhaler or as a pill. The study is complete and focused on side effects and drug leve…