Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New hope for preventing Post-Surgery confusion in seniors

NCT ID NCT05242692

Symptom relief Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving a small amount of s-ketamine during chest surgery could reduce the risk of postoperative delirium (sudden confusion) in patients aged 60 and older. Over 500 participants were randomly assigned to receive either s-ketamine or another drug (dexmedetomidine) during their operation. The goal was to see if s-ketamine works as well as the standard treatment for preventing confusion after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

520 people

The number who actually took part.

Started

Jun 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 60 years or over * Both genders * American anesthesiologist association (ASA) physical status classificationⅠ-Ⅲ * Diagnosed with lung, esophagus, or mediastinum disorders * Undergoing open or video-assisted thoracic surgery including lobectomy, segmentectomy, pneumonectomy, esophagectomy, or resection of mediastinal tumor * General anesthesia with one-lung ventilation (OLV) or bronchial blocker. * An expected operation duration of 2 hours or more. * Voluntarily participate in the trial and sign informed consent. Exclusion Criteria: * History of psychiatric disease or severe depression * History of glaucoma or hyperthyroidism * History of severe hepatic (Child-Pugh grade C) or renal (requirement for renal replacement therapy) disorder. * Body mass index (BMI) greater 35 kg/m2 * Dementia history or baseline Mini-Mental State Examination (MMSE) score less than 23 * Severe audio-visual impairments, or inability to speak Mandarin or Cantonese precluding communication * Sinus bradycardia (heart rate \< 50 beats per minutes, bpm), sick sinus or Wolff- Parkinson-White syndromes, or Ⅱ degree atrioventricular block and over * Poorly controlled hypertension (resting systolic blood pressure over 180 mm Hg, or resting diastolic blood pressure over 100 mm Hg) * Allergic to dexmedetomidine, S-ketamine or any of their formulation ingredients; * Taking sedatives, antidepressants or glucocorticoids * Alcohol or drug abuser * Life expectancy of less than 2 months due to extensive tumor metastasis.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Elderly patients are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Emergence Delirium esophageal disorder lung disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Elderly patients Postoperative delirium

Contacts and locations

Locations

  • Cancer hospital and institute of Guangzhou medical university

    Guangzhou, Guangdong, 510095, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.