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New drug verekitug aims to curb severe asthma attacks

NCT ID NCT06196879

Disease control Sponsor: Upstream Bio Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called verekitug (UPB-101) in 479 adults with severe asthma. The goal was to see if it could reduce asthma attacks and improve lung function compared to a placebo. Participants received either verekitug or a dummy injection over several months. The trial is now complete, and results will show if verekitug is safe and effective for severe asthma.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Verekitug (UPB-101)
What this could lead to
If successful, verekitug could offer a new treatment option to reduce severe asthma attacks and improve breathing control for people with hard-to-control asthma.
What could go wrong
This is a Phase 2 trial, so results are still early. The drug may not work better than placebo, and side effects are possible. Larger studies are needed before it becomes available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

479 people

The number who actually took part.

Started

Feb 2024

Finished

Mar 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signed, dated, and received a copy of the Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved written informed consent form (ICF). * Age 18 to 80 years of age (inclusive) at the time of consent. * Physician-diagnosed asthma for at least 12 months prior to Visit 1. * Participant has evidence of bronchodilator (BD) reversibility as documented by either historical reversibility (within 12 months prior to study entry) or reversibility during screening. * Documented treatment with a total daily dose of either medium or high dose inhaled corticosteroids (ICS) for at least 3 months. Participants on medium dose ICS must also have been taking at least one additional maintenance asthma controller medication for at least 3 months. * Documented history of asthma exacerbation(s) within 12 months of Visit 1. * Asthma Control Questionnaire-6 (ACQ-6) score greater than or equal to (\>=) 1.5 at screening and randomization. * Participant must have a pre-BD FEV1 value of \>=30 percent (%) and \<=80% predicted at Screening. * Minimum compliance with daily diary and background asthma medication(s) as captured in the daily diary during the Run-in Period. * Agrees to follow the required contraceptive techniques/methods. * Female or male participant agrees not to donate eggs or sperm, respectively, for a period of 120 days after the last dose of the study drug intervention or at the Final Visit, whichever occurs last. Exclusion Criteria: * Inpatient hospitalization due to asthma at any time within 4 weeks prior to Visit 1 or during the Screening/Run-in Period. * Previous exposure to verekitug (UPB-101) or known allergy/sensitivity to any of its excipients. * Previous biologics, including those for asthma treatment, for which the appropriate washout period is not fulfilled prior to Visit 1. If the half-life is not known, a 24-week washout period prior to Visit 1 should be applied. * Allergen immunotherapy (unless maintenance dose) within 12 weeks prior to Visit 1 or plans to begin therapy or change dosing during the study. * For participants taking oral corticosteroids (OCS), the dose has not been stable for at least 2 weeks prior to Visit 1 and/or is \>10 milligram (mg) daily, or \>20 mg every other day. * Evidence of active or suspected bacterial, viral, fungal, or parasitic infections within 2 weeks prior to Visit 1. * History compatible with or diagnosis of a parasitic infection and has not been treated or has not responded to standard of care therapy. * Current tobacco smokers, nicotine vapers (including electronic cigarettes), snuff users or participants with a smoking history \>=10 pack years. (Former nicotine smokers with a smoking history of \<10 pack years, former nicotine vapers and former snuff users must have stopped for at least 6 months prior to Visit 1 to be eligible). * Positive coronavirus disease 2019 (COVID-19) test with lower respiratory tract symptoms within 28 days before Visit 1. * Pregnant or breastfeeding or planning to become pregnant or breastfeed during the study or unwilling to use adequate birth control, if of reproductive potential and sexually active.

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Conditions

The condition(s) this trial relates to.

asthma bronchial disorder chronic asthma lung disorder respiratory system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Severe asthma

Contacts and locations

Locations

  • "ALL-MED" Specjalistyczna Opieka Medyczna. Medyczny Instytut Badawczy

    Wroclaw, Dolnoslaskie Voivodeship, 53-201, Poland

  • AA Medical Research Center

    Flint, Michigan, 48504, United States

  • AARA Research Center

    Dallas, Texas, 75231, United States

  • Advance Pharma Research

    Cutler Bay, Florida, 33189, United States

  • Advanced Respiratory and Sleep Medicine LLC

    Huntersville, North Carolina, 28078, United States

  • Alergo-Med Specjalistyczna Przychodnia Lekarska Sp Z O.O.

    Tarnów, Malopolskie Voivodeship, 33-100, Poland

  • Alergologie a imunologie Hofstetr Alois MUDr. s.r.o.

    Jihlava, Czech Republic, 586 01, Czechia

  • Alina Clinical Trials, LLC

    Dallas, Texas, 75225, United States

  • AllerVie Clinical Research

    Birmingham, Alabama, 35209, United States

  • Allergy & Asthma Clinical Research

    Walnut Creek, California, 94598, United States

  • Allianz Research Institute

    Westminster, California, 92683, United States

  • Ambulatory For Specialized Outpatient Medical Care - Individual Practice - Dr. Nikolay Evgeniev Ruse Ltd

    Rousse, 7000, Bulgaria

  • Anderson Allergy And Asthma, PA

    Orlando, Florida, 32806, United States

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asthma/COPD Clinical Research Centre

    Glasgow, Scotland, G12 0YN, United Kingdom

  • Bradford Royal Infirmary

    Bradford, West Yorkshire, BD9 6RJ, United Kingdom

  • CARE: Centro de Alergia y Enfermedades Respiratorias

    Buenos Aires, C1414AIF, Argentina

  • CIMER

    Providencia, 7500657, Chile

  • California Medical Research Associates Inc.

    Northridge, California, 91324, United States

  • Centro Dr. Lazaro Langer Privado Medicina del Aparato Respiratorio

    Córdoba, X5003DCE, Argentina

  • Centro Medico Dharma

    Mendoza, M5500, Argentina

  • Centro Médico BIOREUMA

    Concepción, 4070280, Chile

  • Centro de Medicina Respiratoria

    Concepción del Uruguay, Entre Ríos Province, E3260, Argentina

  • Centrum Badan Klinicznych

    Wroclaw, Dolnoslaskie Voivodeship, 51-162, Poland

  • Centrum Medycyny Oddechowej, Mroz Spolka Jawna

    Bialystok, Podlaskie Voivodeship, 15-044, Poland

  • Centrum Medyczne All-Med Spolka Komandytowa

    Krakow, Malopolskie Voivodeship, 30-033, Poland

  • Chernivtsi Regional Clinical Hospital

    Chernivtsi, 58001, Ukraine

  • Chesapeake Clinical Research Inc

    White Marsh, Maryland, 21162, United States

  • Chungbuk National University Hospital

    Cheongju-si, Chubgbuk, 28644, South Korea

  • Churchill Hospital

    Oxford, Oxfordshire, OX3 7LE, United Kingdom

  • Clinical Site Partners dba Flourish research

    Winter Park, Florida, 32789, United States

  • Clinical Site Partners, LLC dba Flourish Research

    Winter Park, Florida, 32789, United States

  • DCC Convex

    Sofia, 1680, Bulgaria

  • DM Clinical Tomball

    Tomball, Texas, 77375, United States

  • Duckworth Lane Clinical Research Facility

    Bradford, West Yorkshire, BD9 6RJ, United Kingdom

  • Dynamic Drug Advancement

    Ajax, Ontario, L1S 2J5, Canada

  • EMED Centrum Uslug Medycznych

    Rzeszów, Podkarpackie Voivodeship, 35-205, Poland

  • Edward Jenner Research Group, LLC

    Plantation, Florida, 33317, United States

  • El Paso Pulmonary Association

    El Paso, Texas, 79902, United States

  • Element Research Group

    San Antonio, Texas, 78258, United States

  • Emmed Research

    Pretoria, Gauteng, 0002, South Africa

  • Eunpyeong St. Marys Hospital

    Seoul, Korea, 03312, South Korea

  • Exordia Medical Research Inc

    Fall River, Massachusetts, 02723, United States

  • FCRN Clinical Trial Centre

    Vereeniging, Gauteng, 1935, South Africa

  • Fakultni Nemocnice u Sv. Anny v Brne

    Brno, Czech Republic, 602 00, Czechia

  • Fondazione IRCCS Policlinico "San Matteo" - SC Pneumologia'

    Pavia, 27100, Italy

  • Fukuwa Clinics

    Chuo-ku, Tokyo, 104-0031, Japan

  • Fundacion Cidea

    Caba, C1121ABE, Argentina

  • Fundacion Estudios Clinicos (FECLIN)

    Rosario, Santa Fe Province, 2000, Argentina

  • Fundacion Medica San Cristobal

    Santiago, Santiago Metropolitan, 7630226, Chile

  • Fundacion Respirar - Centro Medico Dra. De Salvo

    Buenos Aires, C1426ABP, Argentina

  • Fundacion Scherbovsky

    Mendoza, Mendoza Province, 5500, Argentina

  • Giromed Institute

    Girona, Barcelona, 08017, Spain

  • Greater Houston Memorial Pulmonary and Sleep

    Houston, Texas, 77008, United States

  • Health and Life Research Institute, LLC

    Miami, Florida, 33155, United States

  • Heartlands Hospital, University Hospitals Birmingham NHS Trust

    Birmingham, West Midlands, B9 5SS, United Kingdom

  • Horizon Clinical Research

    Cypress, Texas, 77429, United States

  • Hospital Gregorio Marañon

    Madrid, 28007, Spain

  • Howard County Center for Lung and Sleep Medicine LLC

    Columbia, Maryland, 21044, United States

  • Hull University Teaching Hospitals NHS Trust

    Cottingham, East Yorkshire, HU16 5JQ, United Kingdom

  • IERIM Instituto de Enfermedades Respiratorias e Investigacion Medica

    San Juan Bautista, Buenos Aires, 1888, Argentina

  • IKF Pneumologie Frankfurt, Clinical Research Center Respiratory Diseases

    Hessen, 60596, Germany

  • IKF Pneumologie GmbH & Co. KG

    Mainz, 55128, Germany

  • INSARES

    Mendoza, 5500, Argentina

  • Icegclinic

    Santiago, Santiago Metropolitan, 8241479, Chile

  • InAER

    CABA, C1425BEN, Argentina

  • Instituto Especialidades de la Salud Rosario

    Rosario, Santa Fe Province, 2000, Argentina

  • Integrated Research of Inland Inc

    Upland, California, 91786, United States

  • Investigaciones En Patologias Respiratorias

    San Miguel de Tucumán, Tucumán Province, CP T4000IAP, Argentina

  • KKR Sapporo Medical Center

    Sapporo, Hokkaido, 062-0931, Japan

  • KPPK Studienzentrum

    Koblenz, Rhineland-Palatinate, 56068, Germany

  • Kern Research, Inc.

    Bakersfield, California, 93301, United States

  • Kishiwada City Hospital

    Kishiwada, Osaka, 596-8501, Japan

  • Kyung Hee University Hospital

    Seoul, 2447, South Korea

  • Lekarze Specjalisci - J. Malolepszy I Partnerzy

    Wroclaw, Dolnoslaskie Voivodeship, 54-239, Poland

  • M3 Wake Research

    Las Vegas, Nevada, 89106, United States

  • MC Zdrave 1

    Vratsa, 3320, Bulgaria

  • ME Clinical Respiratory Research Hamburg GmbH

    Hamburg, 22299, Germany

  • MHAT "Rahila Angelova" Pernik

    Pernik, 2300, Bulgaria

  • Malopolskie Centrum Alergologii

    Krakow, Malopolskie Voivodeship, 31-624, Poland

  • Mayflower Clinical

    Marble Falls, Texas, 02747, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Medconsult Pleven

    Sofia, 1756, Bulgaria

  • Medical Center Excelsior

    Sofia, 1407, Bulgaria

  • Medical Center HERA EOOD

    Sofia, 1510, Bulgaria

  • Medical Center New Rehabilitation Center EOOD

    Stara Zagora, 6001, Bulgaria

  • Medical Centre "Neuromed" of Limited Liability Company "Scan Light"

    Vinnytsia, 21050, Ukraine

  • Medical center Pulmovizhyn

    Sofia, 1756, Bulgaria

  • Metroplex Pulmonary and Sleep Center Drive

    McKinney, Texas, 75069, United States

  • Municipal non-Profit Enterprise "lvano-Frankivsk Regional Phthisiology-Pulmonology Center of lvano-Frankivsk regional council

    Ivano-Frankivsk, 76018, Ukraine

  • National Hospital Organization Ibarakihigashi National Hospital

    Ibaraki, 319-1113, Japan

  • National Jewish Health

    Denver, Colorado, 80206, United States

  • Newport Native MD Inc

    Newport Beach, California, 92663, United States

  • Newtown Clinical Research Centre

    Johannesburg, Gauteng, 2001, South Africa

  • Nouvelle Clinical Research

    Miami, Florida, 33189, United States

  • Nzoz Atopia

    Krakow, Malopolskie Voivodeship, 31-159, Poland

  • OK Clinical Research, LLC

    Edmond, Oklahoma, 73034, United States

  • Office of Hector H. Altieri MD

    San Miguel de Tucumán, Tucumán Province, 4000, Argentina

  • Oji General Hospital

    Tomakomai, Hokkaido, 053-8506, Japan

  • Ormeau Clinical Trials Ltd

    Belfast, Northern Ireland, BT7 2EB, United Kingdom

  • Osaka Habikino Medical Center

    Habikino, Osaka, 583-8588, Japan

  • Osaka Metropolitan University Hospital

    Osaka, 545-0051, Japan

  • Ospedale San Martino

    Genova, 16132, Italy

  • Ostrowieckie Centrum Medyczne spolka cywilna Anna Olech-Cudzik, Krzysztof Cudzik

    Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, 27-400, Poland

  • Ottawa Allergy Research Corp

    Ottawa, Ontario, K1H 1E4, Canada

  • PNEUMOLOGIE VARNSDORF s.r.o.

    Varnsdorf, Czech Republic, 407 47, Czechia

  • POIS Sachsen GmbH

    Leipzig, Saxony, 04347, Germany

  • Phoenix Medical Research

    Miami, Florida, 33165, United States

  • Pivotal Research Solutions

    Stonecrest, Georgia, 30038, United States

  • Plicni Stredisko Teplice S.R.O

    Teplice, Czech Republic, 415 01, Czechia

  • Pneumologisches Studienzentrum

    Berlin, 10961, Germany

  • Portland Clinical Research

    Clackamas, Oregon, 97015, United States

  • Prywatny Gabinet Lekarski Malgorzata Pawlukiewicz

    Rzeszów, Podkarpackie Voivodeship, 35-051, Poland

  • Pulmonary Research Institute of Southeast Michigan

    Farmington Hills, Michigan, 48336, United States

  • R&B Medical Center

    Tampa, Florida, 33614, United States

  • RCMS/Lungenpraxis Hohenzollerndamm

    Berlin, 10717, Germany

  • RNA America Health Sciences

    Sugar Hill, Georgia, 30518, United States

  • Research Institute of South Florida

    Miami, Florida, 33173, United States

  • Royal Liverpool University Hospital

    Liverpool, Merseyside, L7 8XP, United Kingdom

  • SSD Asma Grave e Malattie Rare del Polmone, AOU San Luigi Gonzaga

    Orbassano, Torino, 10043, Italy

  • Samsung Medical Center

    Seoul, 6351, South Korea

  • Sante Clinical Research

    Kerrville, Texas, 78028, United States

  • Seoul National University Hospital

    Seoul, 3080, South Korea

  • Sociedad medica Sy G Limitada

    Santiago, 7501126, Chile

  • Soonchunhyang University Bucheon Hospital

    Bucheon-si, 14584, South Korea

  • St Augustine's Hospital/Dr. IA Abdullah

    Durban, KwaZulu-Natal, 4001, South Africa

  • St Peter's Hospital

    Chertsey, Surrey, KT16 0PZ, United Kingdom

  • Summit Research Group LLC

    Munroe Falls, Ohio, 44262, United States

  • Synapta Clinical Research Centre

    Durban, 4001, South Africa

  • The Catholic University of Korea, Seoul St. Marys Hospital

    Seoul, Republic of Korea, 06591, South Korea

  • Tokyo-Eki Center-building Clinic

    Chuo-ku, Tokyo, 103-0027, Japan

  • Toledo Institute of Clinical Research Inc

    Toledo, Ohio, 43617, United States

  • Toronto Allergists

    Toronto, Ontario, M5G1E2, Canada

  • Treasure Valley Medical Research

    Boise, Idaho, 83706, United States

  • UMHAT Sveti Georgi

    Plovdiv, 4001, Bulgaria

  • UOSD Allergologia e Immunodeficienze dell'A.O.U. Federico II

    Naples, 80131, Italy

  • Unique Clinical Trials

    Doral, Florida, 33172, United States

  • University of Cape Town Lung Institute

    Cape Town, Western Cape, 7700, South Africa

  • University of Wisconsin--Madison

    Madison, Wisconsin, 53792, United States

  • Uniwersyteckie Centrum Kliniczne, Klinika Alergologii i Pneumonologii

    Gdansk, Pomorskie Voivodeship, 80-214, Poland

  • Urban Health Plan INC

    The Bronx, New York, 10459, United States

  • Velocity Clinical Research

    West Jordan, Utah, 84088, United States

  • Velocity Clinical Research - Anderson

    Anderson, South Carolina, 29621, United States

  • Velocity Clinical Research - Lafayette LA

    Los Angeles, California, 70508, United States

  • Velocity Clinical Research - Medford

    Medford, Oregon, 97504, United States

  • Velocity Clinical Research - Meridian

    Meridian, Idaho, 83642, United States

  • Velocity Clinical Research - Spartanburg

    Spartanburg, South Carolina, 29303, United States

  • Velocity Clinical Research Germany , Berlin

    Berlin, 10787, Germany

  • WR-ClinSearch, LLC

    Chattanooga, Tennessee, 37421, United States

  • WR-Notus Clinical Research, LLC

    Charleston, South Carolina, 29414, United States

  • Winchester Hospital

    Winchester, Ontario, K0C 2K0, Canada

  • Woodland Clinic Medical Group

    Woodland, California, 95695, United States

  • Yeungnam University Hospital

    Daegu, 42415, South Korea

  • Yokohama City University Medical Center

    Yokohama, Kanagawa, 232-0024, Japan

  • Yonsei University Health System - Severance Hospital

    Seoul, 3722, South Korea

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