Infectious disease with sepsis

This study follows women who previously received the GBS-NN/NN2 vaccine during pregnancy to see how long their immune protection lasts. It also tests whether a booster dose given in a new pregnancy is safe and boosts immunity, aiming to protect newborns from group B strep infecti…

This study looks at 600 ICU patients with hospital-acquired sepsis to see if giving antibiotics continuously or adding a second antibiotic improves survival. Patients will be randomly assigned to receive a beta-lactam antibiotic either continuously or intermittently, and some wil…

This trial compares two treatments for people with severe sepsis who also have adrenal insufficiency, a condition where the adrenal glands do not make enough cortisol. Researchers test whether giving fludrocortisone along with hydrocortisone works better than hydrocortisone alone…

This trial tests two blood purification treatments—AN69-oXiris and polymyxin B hemoperfusion—in intensive care patients with sepsis caused by abdominal infections. The goal is to see which method better reduces endotoxin, a bacterial toxin that fuels inflammation, and whether tha…

This study tests whether Racecadotril, a drug given through a feeding tube, can help reduce organ injury in people with sepsis. About 44 adults in intensive care will receive either the drug or a placebo, along with standard sepsis treatment. The main goal is to see if organ func…

This study was designed to test whether adding an experimental drug and special immune cells to standard care could help critically ill adults with severe pneumonia, especially those with sepsis or lung failure. The trial was withdrawn before enrolling any participants, so no res…

This study was designed to see if adding two immune treatments (NAI and iNKT cells) to standard care could help critically ill adults with severe pneumonia, sepsis, or lung failure recover. It planned to enroll ICU patients and follow them for 90 days. However, the study was with…

This study tests esketamine, a drug related to ketamine, for sedation and delirium prevention in 80 septic patients who need a breathing tube. The goal is to see if esketamine can reduce time on the ventilator and improve survival compared to standard sedatives. The trial is acti…

This study tests a structured nutrition plan for 300 ICU patients who had abdominal surgery and cannot eat normally. The plan includes IV nutrition, oral supplements, and a device to measure calorie needs. Researchers will track infections, ICU stay length, and muscle loss to see…

This study planned to test a treatment called MET-2, a mix of gut bacteria, to help clear antibiotic-resistant germs from the body after a bloodstream infection. It was designed for adults not in intensive care who had a resistant infection. The trial was withdrawn before enrolli…

This study tests whether 7 days of antibiotics works as well as the standard 14 days for treating a serious bloodstream infection caused by Pseudomonas bacteria. About 300 adults who have already received 6 days of treatment will be randomly assigned to stop at 7 days or continue…

This study tests whether giving the steroid hydrocortisone early, right when shock is diagnosed, helps very small preterm babies (under 1500 grams) recover faster. Researchers will compare babies who get standard shock treatment plus hydrocortisone to those who get standard treat…

This phase 2 trial tests emapalumab, a drug that blocks a protein called interferon-gamma, in 75 adults with sepsis caused by a specific immune overreaction. The goal is to see if the drug can reduce organ failure, measured by a drop in the SOFA score. Participants are in ICUs ac…

This study looks at whether a strong antibiotic called meropenem (a carbapenem) works better than another antibiotic called piperacillin/tazobactam for treating sepsis in burn patients. Sepsis is a life-threatening infection that can happen after severe burns. The study will trac…

This study was designed to see if a device called LifeFlow could deliver fluids faster to children with sepsis compared to the usual push-pull method. The trial planned to include 600 children but was withdrawn before any participants were enrolled. No results are available.

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

This study is testing whether measuring a substance called IL-6 in the blood can help predict which patients with sepsis or septic shock are most likely to die within 28 days. Researchers will enroll 700 adults in intensive care units (ICUs) and follow them for 28 days. If the te…

This study looks at whether taking blood for culture in one go is as good as taking it from two separate spots to find bloodstream infections. Adults with suspected infections will have blood drawn twice: first, a larger sample from one vein, then a smaller sample from another ve…

This study tests a finger-clasp device called Lab Clasp that measures lactate from fluid just under the skin, similar to a pulse oximeter. Researchers want to see if it matches standard blood tests in 6 healthy adults. If it works, it could make sepsis monitoring easier and less …

This study is testing whether a blood test called Monocyte Distribution Width (MDW) can quickly identify patients with bacteria in their blood (bacteremia) in the emergency department. Researchers will observe 50,000 patients who have blood cultures ordered, comparing MDW results…

This study compares two blood tests—mass change in serum albumin and serum lactic acid—to see which better predicts whether non-surgical ICU patients with sepsis will be discharged or die. Researchers will track 40 adults aged 18-70 with sepsis, excluding those with liver disease…

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

This study is measuring certain substances in the blood, stool, saliva, and airway fluid of 200 adults with sepsis. The goal is to see if these biomarkers, combined with standard medical data, can predict which patients are more likely to die or develop long-term critical illness…

Researchers at two Beijing hospitals are following more than 800 patients who develop sepsis after surgery. The team collects clinical data and biological samples to map immune patterns linked to acute kidney injury. Using multi-omics and single-cell sequencing, they aim to build…

Researchers at the University of Florida are studying sepsis survivors in the surgical intensive care unit to understand why some develop chronic critical illness, a condition marked by persistent inflammation, immune suppression, and muscle wasting. The trial follows 668 adults,…

This study tracks how paramedics use the ZOLL 731 ventilator when helping people with serious conditions like cardiac arrest, sepsis, or heart failure before they reach the hospital. Researchers will record which ventilator modes and settings are used, and how often alarms go off…

This study at Mayo Clinic is testing whether a simple blood test can measure organ damage and immune system changes in people with sepsis. Researchers will take one extra blood sample from 1,000 patients in the emergency department and use advanced DNA analysis to look for signal…

This study follows thousands of critically ill patients in intensive care units across China to better understand sepsis, a life-threatening condition where the body's response to infection damages its own organs. Researchers will collect detailed information on infections, treat…

This study will observe how safe and effective the antibiotic Zavicefta is when used in everyday medical practice in Japan. It includes 59 patients with sepsis (a severe blood infection) or reduced kidney function who are receiving Zavicefta for the first time. Researchers will t…

This study looks back at medical records from four hospitals in Thailand to understand what happens when doctors reduce antibiotic treatment (de-escalation) in patients who received short-course IV antibiotics. It compares outcomes like new resistant infections and death between …

This study compares a standard early-warning system called NEWS2 with a machine-learning model to see which can detect sepsis earlier in hospital patients. Researchers will monitor 100 adults admitted with suspected infection, recording when each system first raises an alert and …

This study looks at whether measuring lactate in stool can help doctors predict how well critically ill patients with low blood flow will respond to treatment. About 40 adults in the ICU will provide a stool sample within 24 hours of admission. Researchers will check if high stoo…

This study at St. Jude Children's Research Hospital is testing whether a next-generation DNA test can predict bloodstream infections in children and teens with cancer who are at high risk. Current methods often detect infections too late, leading to severe illness or death. The g…

This study follows 2,400 critically ill patients in intensive care units across China to better understand sepsis, a life-threatening condition where the body's response to infection damages its own organs. Researchers will collect detailed data on infections, immune responses, a…

This study looks at how the immune system bounces back in people who survive a severe bloodstream infection caused by Staphylococcus aureus bacteria. Researchers are measuring specific immune markers, like HLA-DR on monocytes, to see if recovery differs between people with and wi…

This study examines medical records from 10,000 people who had sepsis (blood poisoning) and developed dangerous blood clots (VTE) while in the ICU. Researchers want to see how many also had a serious blood disorder called DIC, which can cause clots throughout the body. By looking…

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…

This study looks at whether using a simple bedside ultrasound exam on all hospitalized patients can shorten their hospital stay. Researchers will check the heart, kidneys, liver, and lungs for common problems. The goal is to see if this routine check helps doctors make faster dec…

This study gathers 35-50 international critical care experts to agree on how to classify and manage septic shock using point-of-care ultrasound. The goal is to create consensus statements that could help personalize treatment. No patients are enrolled; instead, experts complete s…

This observational study of 16,000 ICU patients aims to find if age- and sex-specific blood lactate levels better predict death risk than the current standard threshold. Researchers will analyze hospital data from 2016-2024, focusing on sepsis patients. The goal is to improve ear…

This study looks at small molecules called microRNAs in the blood of people with sepsis, a severe bloodstream infection. Researchers want to see if changes in these molecules can help predict who will survive. About 150 participants will provide blood samples, and their microRNA …

This study aimed to see if an artificial intelligence system could predict sepsis—a serious infection—in people recovering from abdominal surgery. Researchers planned to use wearable sensors and hospital data to spot early warning signs. However, the study was withdrawn before en…

This study aimed to see if supportive text messages help sepsis patients track and share their health data after leaving the hospital. It was withdrawn before enrolling anyone, so no results are available. The goal was to improve how patient-reported information is collected and …

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors make better decisions about fluids and dialysis. However, the study was withdrawn before enrolling any par…

This study looks at how sepsis, a severe infection, can cause heart problems in intensive care patients. Researchers will collect data, blood samples, and heart ultrasound images from 330 adults with septic shock. The goal is to find patterns that help doctors better diagnose and…

This study was designed to explore whether problems with mitochondria—the energy powerhouses in cells—play a role in causing heart damage in people with sepsis. Researchers planned to compare blood samples from sepsis patients and healthy volunteers to look for links between mito…

This study tests a new microfluidic device that uses a very small blood sample to measure how well immune cells (neutrophils) function in premature newborns. The goal is to see if this test can predict which babies will develop sepsis, a life-threatening infection. Researchers wi…

This study follows 312 older adults who survived a critical illness to see how much they moved during their ICU stay. Researchers want to learn if more activity leads to less disability, better mobility, and clearer thinking 3 to 12 months later. The goal is to find ways to impro…

This study tests whether using rapid, advanced lab tests to identify the exact bacteria causing a severe infection can help doctors choose the right antibiotics faster. About 190 adults with sepsis in Greek ICUs will either get standard care or the new testing strategy. The goal …

This study looks at a gene called TRIM25 in blood cells of people with sepsis—a life-threatening infection that can damage organs. Researchers will compare these gene activity levels between sepsis patients and non-sepsis patients. The goal is to find new markers that could lead …

This study looks at how the antibiotic cefazolin behaves in the blood of people on chronic hemodialysis who have catheter infections. Researchers will take blood samples at different times to measure drug levels. The goal is to find the best dose to treat infections while avoidin…

This study looks at 120 adults getting a left ventricular assist device (LVAD) to see how often infections happen and how their immune system changes after surgery. The goal is to find what makes some patients more likely to get infections. This research does not test a new treat…

This study was designed to measure how stiff the arteries are in intensive care patients receiving drugs to support their heart or blood pressure. The goal was to see if a simple monitor reading could help doctors adjust treatment. However, the study was withdrawn before any pati…

This study looks at blood markers in 90 sepsis patients who develop confusion or delirium. Researchers will take blood samples over 72 hours to measure proteins linked to brain injury. The goal is to find patterns that predict recovery or long-term problems.

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that can quickly tell if someone has a bloodstream infection, which could help diagnose sepsis faster. About 100 adults with gum disease ar…

This study looks at two ways of setting a breathing machine (ventilator) for people with sepsis who need help breathing. One method is personalized based on each patient's lung measurements, while the other is a standard approach. Researchers will use CT scans to see how air move…

This study looks back at medical records of about 5,000 people with a serious bloodstream infection caused by a common bacterium. Researchers compare two antibiotic treatments to see which one leads to better survival and fewer side effects. The goal is to find out if a newer opt…