Cholelithiasis
MONDO:0012672The presence of crystallized deposits forming in the gallbladder or biliary tree, primarily composed of cholesterol, bilirubin, and bile.
Also known as: gallstones
108 clinical trials for this condition and its sub-types, 74 tagged with Cholelithiasis itself.
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Sub-types of Cholelithiasis
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Choledocholithiasis 40 trials
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Cholecystolithiasis 14 trials
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Gallbladder disease 1 1 trial
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Primary intrahepatic lithiasis 0 trials
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One surgery or two? study tests combining gallbladder removal with Weight-Loss surgery
Disease control CompletedThis study looks at whether it is safe to remove the gallbladder at the same time as laparoscopic sleeve gastrectomy (a common weight-loss surgery) in patients who are at high risk due to age, multiple health problems, or increased anesthesia risk. It compares patients who had bo…
Sponsor: Zagazig University • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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New drug may shorten jaundice in gallstone patients
Disease control CompletedThis study looked at whether a drug called Remaxol can help people with gallstones and a serious complication called obstructive jaundice. Obstructive jaundice happens when a gallstone blocks the bile duct, causing yellowing of the skin and eyes. The study involved 286 adults who…
Sponsor: POLYSAN Scientific & Technological Pharmaceutical Company • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New balloon method may simplify bile duct stone removal during gallbladder surgery
Disease control CompletedThis study tested a technique where a balloon is used to widen the bile duct opening and clear stones during emergency gallbladder removal surgery. 100 adults with bile duct stones took part. After surgery, an MRI scan checked if all stones were gone. The goal was to see if this …
Sponsor: North Estonia Medical Centre • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Can a tiny plastic stent keep gallstones away before surgery?
Disease control CompletedThis study looked at whether placing a temporary plastic tube (stent) in the bile duct after removing gallstones helps prevent stones from returning while patients wait for gallbladder surgery. 200 adults with both gallbladder and bile duct stones took part. Half got the stent, h…
Sponsor: National Liver Institute, Egypt • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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New 'Smart' cut during ERCP aims to slash complication rates
Disease control CompletedThis study tested a new way to open the bile duct during an ERCP procedure. Instead of the standard pull-type cut, doctors used a special hooked knife (ASD) designed to cut only the circular muscle layer, potentially causing less damage. Over 1,500 patients were randomly assigned…
Sponsor: Military Medical Clinical Center of the Southern Region, Ukraine • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Blood test may spot hidden gallbladder cancer in gallstone patients
Diagnosis CompletedThis study looks at whether ten specific substances in the blood can help tell apart patients with gallbladder cancer from those with only gallstone disease. Researchers will measure these markers in a new group of Chilean patients to confirm earlier findings. If the markers prov…
Sponsor: Centre Paul Strauss • Aim: Diagnosis
Last updated Aug 06, 2026 00:00 UTC
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Acupuncture needles take on Post-Surgery nausea
Prevention CompletedThis study tested whether adding acupuncture to standard anti-nausea drugs could better prevent nausea and vomiting after laparoscopic gallbladder removal. 270 adults scheduled for surgery received either acupuncture plus standard drugs or standard drugs alone. The goal was to se…
Sponsor: Baylor College of Medicine • Aim: Prevention
Last updated Jun 27, 2026 09:09 UTC
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Robot could remove gallbladder and clear bile duct stones in one operation
Symptom relief CompletedResearchers at National Taiwan University Hospital are testing whether a single-port robotic surgery system can safely remove the gallbladder and clear stones from the bile duct in one operation. The study enrolls 24 adults with symptomatic gallstones, with or without bile duct s…
Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
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Tiny Star-Shaped cuts may make gallbladder removal easier and less painful
Symptom relief CompletedThis study tested a new way to remove a stubborn gallbladder during keyhole surgery. When the gallbladder is too large or thick to pull out easily, surgeons often make a bigger cut, which can cause bleeding and pain. The new method uses three tiny star-shaped cuts around the open…
Sponsor: Bangladesh Navy • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Nerve block may ease pain after gallbladder removal
Symptom relief CompletedThis study tested whether a nerve block called a TAP block can reduce pain after laparoscopic gallbladder removal. Sixty adults were split into two groups: one received the block plus standard painkillers, the other only standard painkillers. Researchers measured pain levels and …
Sponsor: Esencan Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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New nerve block may cut opioid use after gallbladder surgery
Symptom relief CompletedThis study tested whether a rectointercostal nerve block can reduce pain and the need for strong painkillers after laparoscopic gallbladder removal. 60 adults having elective surgery received the block as part of their pain management plan. The goal was to see if it lowers opioid…
Sponsor: Ankara Etlik City Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Shh! quiet anesthesia may ease pain and nausea after gallbladder surgery
Symptom relief CompletedThis study looked at whether reducing noise during the start of anesthesia (when you go to sleep) can improve recovery after laparoscopic gallbladder removal. 105 adults having planned surgery were included. Researchers measured pain, nausea, vomiting, heart rate, blood pressure,…
Sponsor: Namik Kemal University • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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Nerve block eases pain after gallbladder surgery, study finds
Symptom relief CompletedThis study looked at whether a TAP block (a type of nerve block) can reduce pain after laparoscopic gallbladder removal. Sixty adults were split into two groups: one got the TAP block with numbing medicine after surgery, the other did not. Researchers measured pain levels and how…
Sponsor: Darul Sehat Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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New painkiller cocktail cuts opioid use after gallbladder surgery
Symptom relief CompletedThis study looked at whether adding dexmedetomidine to a common numbing medicine (bupivacaine) could improve pain control after laparoscopic gallbladder removal. Thirty adults having elective surgery were randomly assigned to receive either the combo or bupivacaine alone, sprayed…
Sponsor: Ain Shams University • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Foot massage with essential oils may ease pain after gallbladder surgery
Symptom relief CompletedThis study tested whether aromatherapy foot massage can reduce pain, improve sleep, and speed recovery after laparoscopic gallbladder removal. 103 adults received two 10-minute foot massages with essential oils after surgery. Researchers measured pain, sleep quality, and recovery…
Sponsor: Ataturk University • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Pain relief showdown: ketamine vs lidocaine after surgery
Symptom relief CompletedThis study tested two common painkillers, ketamine and lidocaine, to see which works better for pain after gallbladder removal. 76 adults were randomly assigned to receive one of the drugs right after surgery. Researchers measured their pain levels over the next 24 hours. The goa…
Phase 1 • Sponsor: Liaquat National Hospital & Medical College • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Which painkiller works better after gallbladder removal? lidocaine vs. magnesium
Symptom relief CompletedThis study tested two common drugs, lidocaine and magnesium sulfate, to see which one works better for pain after gallbladder removal surgery. 168 adults received one of the two drugs during surgery, and their pain levels were checked at several points over 24 hours. The goal was…
Phase 1 • Sponsor: Liaquat National Hospital & Medical College • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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New pain block beats standard injection after gallbladder surgery
Symptom relief CompletedThis study tested different ways to control pain after laparoscopic gallbladder removal in 160 adults. Patients received either a TAP block (an injection into the abdominal wall muscles), local anesthetic at the incision sites, both, or no extra pain relief. The TAP block group r…
Sponsor: University of Warmia and Mazury in Olsztyn • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Which pain block works best after belly surgery?
Symptom relief CompletedThis study tested two types of nerve blocks—Quadratus Lumborum (QL) and Erector Spinae (ESP)—to see which provides better pain relief after abdominal surgery. 100 adults having surgery for colorectal, prostate, or kidney cancer, or gallbladder removal, received one of the blocks …
Sponsor: Jagiellonian University • Aim: Symptom relief
Last updated Jun 26, 2026 13:51 UTC
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Which anesthesia gas is easier on the lungs? new trial aims to find out
Knowledge-focused CompletedThis study compares two common anesthesia gases, sevoflurane and desflurane, to see which one puts less strain on the lungs during gallbladder removal surgery. Researchers will measure lung mechanics at three points during the operation in 138 adults. The goal is to find out if o…
Sponsor: Konya City Hospital • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Battle of the belly buttons: which incision is best for gallbladder surgery?
Knowledge-focused CompletedThis study compared two methods of creating the first opening (pneumoperitoneum) in laparoscopic gallbladder removal: one through the belly button and one just below it. Researchers looked at how fast each method was, complications, pain, hospital stay, and cosmetic satisfaction.…
Sponsor: Dr Mudassar Saeed Pansota • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Ultrasound vs. reality: can scans predict tough gallbladder surgeries?
Knowledge-focused CompletedThis study looked at 130 patients with gallstones who had their gallbladder removed by keyhole surgery. Researchers compared the ultrasound results done before surgery with what the surgeon actually found during the operation. The goal was to see if ultrasound can predict when th…
Sponsor: Nepal Medical College and Teaching Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Colombian hospital study reveals gaps in gallbladder care
Knowledge-focused CompletedThis study looked back at the medical records of 609 people treated for gallbladder inflammation (cholecystitis) in Villavicencio, Colombia, between 2019 and 2022. The goal was to understand how quickly patients received care, what treatments they got, and how many had complicati…
Sponsor: Hospital Departamental de Villavicencio • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Fatty liver may cloud surgical imaging, new study finds
Knowledge-focused CompletedThis study looked at 150 adults having gallbladder surgery to see if fatty liver disease (MAFLD) makes a special imaging technique less clear. The imaging uses a dye to help surgeons see bile ducts. Researchers found that fatty liver can reduce image quality and created a way to …
Sponsor: Zhujiang Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Simple breathing change before surgery may prevent stomach issues
Knowledge-focused CompletedThis study looked at 128 people having gallbladder surgery to see if giving them extra oxygen before anesthesia (instead of using a mask to help them breathe) would reduce stomach bloating and sore throat. The researchers compared two groups: one that got mask ventilation and one…
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Glow-in-the-Dark dye could make gallbladder surgery safer
Knowledge-focused CompletedThis study tested whether using a dye called indocyanine green along with infrared light helps surgeons see the bile ducts more clearly during gallbladder removal surgery. Over 600 adults having their gallbladder taken out were randomly assigned to either standard white light or …
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Deep sleep or light nod? study probes best sedation for gallstone procedure
Knowledge-focused CompletedThis study looked at over 121,000 procedures to remove gallstones from the bile duct using a scope (ERCP). Researchers wanted to see if the level of sedation given during the procedure affected whether stones were left behind. They found that deeper sedation might help the doctor…
Sponsor: Karolinska Institutet • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC