Cardiac arrest

This trial tests whether giving naloxone during CPR helps people who have a cardiac arrest in the hospital. Naloxone is a drug that blocks opioid effects, and researchers want to see if it improves survival and recovery. About 850 adults who receive adrenaline during CPR will be …

This trial tests whether a communication training program for emergency dispatchers can help them recognize cardiac arrest over the phone and guide callers to start CPR faster. The study involves about 987 adults who experience cardiac arrest outside of a hospital and call the SA…

This trial tests whether specific care strategies used in the intensive care unit after cardiac arrest can improve neurological recovery and survival. Adults who remain comatose after their heartbeat is restored will be cared for using either head elevation or a near-supine posit…

This study tests whether an external abdominal tourniquet can temporarily block blood flow to the lower body during cardiac arrest, redirecting it to the brain and heart. Researchers will try it on 5 adults with non-traumatic cardiac arrest outside a hospital. The goal is to see …

This study compares two CPR methods for newborns with cardiac arrest: a new technique that combines chest compressions with sustained lung inflation versus the standard 3:1 compression-to-ventilation ratio. Researchers will enroll 554 newborns across multiple hospitals to see whi…

This study tests whether mirabegron, a drug typically used for overactive bladder, can reduce dangerous heart rhythms in people with heart disease. Twenty adults with an implanted defibrillator and frequent ventricular tachycardia will take the drug for two months. Researchers wi…

This study looks at whether giving volunteer community responders a small, portable defibrillator (about the size of a chocolate bar) helps them treat people having a cardiac arrest outside the hospital. Around 1,000 volunteers in Singapore will carry the device for up to a year …

This trial will test whether using smaller breaths (350ml) during CPR helps more people survive cardiac arrest compared to standard larger breaths (600ml). Paramedics will treat 1656 adults with presumed cardiac arrest. The main goal is to see if the smaller breaths lead to more …

This study tests whether using special devices to precisely control breathing during CPR can help more people survive a cardiac arrest. About 852 adults who have a cardiac arrest in the hospital will be randomly assigned to either standard manual breathing help or breathing tailo…

This study looks at whether giving a smaller dose of epinephrine (0.5 mg) during a heart attack outside the hospital helps more people survive with better brain function than the usual dose (1 mg). About 4,336 adults will be randomly assigned to receive either the low or standard…

This study tests a new CPR method called Bio-CPR, which synchronizes chest compressions with ventilation using a machine. Researchers will compare it to standard CPR in 408 adults who have a witnessed cardiac arrest. The goal is to see if this coordinated approach improves breath…

This study tests two heart ablation methods—right atrial only vs. bi-atrial—to see which better prevents fainting caused by reflex syncope. Fifty adults aged 18–60 with severe, recurrent fainting will be monitored with an implantable loop recorder. The goal is to find the most ef…

This study tests a new way to place an emergency IV line through the umbilical cord in newborns who need urgent resuscitation. The procedure aims to deliver adrenaline faster than the standard method. Researchers will enroll 26 full-term babies to see if the new technique can res…

This trial tests whether a Doppler ultrasound patch placed on the neck can quickly and accurately detect when a cardiac arrest patient's heart starts beating again during emergency resuscitation. The patch's readings are compared to those from an arterial line, the gold standard …

This study tests whether a simple bedside ultrasound of the inferior vena cava can detect low blood volume in shock patients as accurately as the standard invasive central venous pressure monitoring. Researchers will enroll 80 adults with shock from blood loss, infection, or othe…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

Emergency medical services teams use defibrillator pads to shock the heart during out-of-hospital cardiac arrest. The VECTORS trial compares two standard pad placements: one with pads on the front and back of the chest, and one with pads on the front and side. Researchers will tr…

Researchers are testing whether giving naloxone soon after resuscitation starts can help people whose hearts stop outside the hospital after an opioid overdose. The trial enrolls adults in out-of-hospital cardiac arrest who are at risk of opioid involvement and who have received …

Cardiac arrest survival in hospitals stays low, and staff on regular wards rarely face these emergencies. Researchers are studying a simulation-based self-training program that lets nurses, doctors, and assistants practice CPR without leaving their department. The study looks at …

This study investigates whether levels of a protein called neurofilament light chain (NFL) in the blood can predict neurological recovery in people who remain comatose after a cardiac arrest. Researchers will measure NFL at several time points over the first week in the ICU and c…

This study looks back at the medical records of 300 people with arrhythmogenic cardiomyopathy who have an implantable cardioverter-defibrillator (ICD) and have had dangerous heart rhythms. Researchers want to count how often ICD-related problems occur, such as lead failure or ina…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study aims to see if improving how emergency dispatchers handle calls and model their actions can speed up the detection of cardiac arrest and improve CPR quality. Researchers will study 4,000 people who experience cardiac arrest outside of a hospital. The goal is to learn i…

This study follows 75 volunteer first responders who are alerted via a smartphone app to help in out-of-hospital cardiac arrests. Researchers want to understand how these stressful events affect the volunteers' mental health and whether a structured follow-up conversation can hel…

This study examines whether volunteers alerted by a smartphone app can improve survival for people who have a cardiac arrest outside the hospital. Researchers will compare outcomes for about 5,200 adults who either did or did not receive help from these first responders. The goal…

This study will collect information on 1,200 emergency intubations across multiple hospitals in Taiwan. Researchers will track how often the tube is placed correctly on the first try and how often serious problems like low oxygen, low blood pressure, or cardiac arrest occur. The …

This study explores whether drones can deliver automated external defibrillators (AEDs) faster than traditional ambulances in simulated cardiac arrest scenarios. Researchers will compare drone and ambulance response times in different city locations and traffic conditions. Twenty…

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and compare the settings doctors used with those suggested by a computer algorithm. The goal is to improve future care…

This study tests a drug called GC7 in 20 people who have had a cardiac arrest and been revived. The goal is to see if GC7 can reduce cell damage caused by the sudden return of blood and oxygen. Researchers will measure stress levels in blood cells and look for signs of improved r…

This study tests a machine learning device that uses heart tracings (ECG) to predict if a person will have another cardiac arrest after being revived. Researchers will first see if EMS providers find the device useful in simulated scenarios, then test its accuracy in 68 real pati…

This study looks at how often colon damage (ischemia) happens in people who survive cardiac arrest and receive CPR. Researchers will perform a bedside colonoscopy 24-36 hours after CPR to check for colon injury. The goal is to better understand this complication and improve care …

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study looks at whether measuring changes in exhaled carbon dioxide (a breath test) during a leg-raising maneuver can help predict if a critically ill patient needs more fluids. Doctors often struggle to balance giving enough fluids without causing harm from too much. The stu…

This study looks at whether people with certain heart rhythm disorders also carry genetic variants linked to a rare muscle condition called non-dystrophic myotonia. Researchers will review medical records of 570 participants and invite some for a neurological exam and electromyog…

This study looks at whether getting a CT scan sooner after a person's heart stops outside the hospital and is revived can help them live longer. Researchers will review records from 5,000 adults treated at six hospitals in Taiwan. The goal is to find the best timing for CT scans …

This study looks at 5,000 patients who survived a cardiac arrest and were admitted to the intensive care unit (ICU). Researchers will use artificial intelligence to analyze past medical records and create a model that predicts how long a patient will stay in the ICU, their brain …

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

This study compares a standard high-field MRI with a portable low-field MRI to see if the portable version can detect brain damage in people in a coma after cardiac arrest. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two …