Brain neoplasm

This early-phase trial tested whether giving activated natural killer (NK) cells, with or without a protein called rhIL15, is safe and feasible for children and young adults with solid tumors that didn't respond to other treatments. Sixteen participants received chemotherapy to l…

This phase 2 trial is testing whether combining two chemotherapy drugs—temozolomide and topotecan—can help children with neuroblastoma, brain tumors, or other solid tumors that have come back or not responded to standard treatment. Participants receive temozolomide by mouth and t…

This phase 1 study tested a drug called D2C7-IT in 81 adults with recurrent malignant glioma (a type of brain tumor). The drug is a lab-made antibody linked to a toxin that targets specific proteins on tumor cells. It was infused directly into the tumor over 72 hours using thin t…

This small pilot study tested whether combining focused ultrasound with a second round of radiation is safe for people with recurrent glioblastoma, an aggressive brain cancer. Seven adults who had already tried standard treatments received the combination therapy. The goal was to…

This pilot study tested a device called NaviFUS that uses focused ultrasound to temporarily open the blood-brain barrier, combined with the drug bevacizumab (Avastin), in 6 patients with recurrent glioblastoma (a type of brain cancer). The goal was to see if the combination is sa…

This study looked at whether a sedative called dexmedetomidine can protect the brain during surgery to remove a brain tumor. 56 adults having brain tumor surgery received either the drug or a placebo. The goal was to see if the drug reduces brain damage and inflammation, helping …

This early-phase study tested a new drug called CUDC-907 in 26 children and young adults (ages 1-21) with cancers that had come back or stopped responding to treatment, including solid tumors, brain tumors, and lymphoma. The main goal was to find a safe dose and check for side ef…

This completed Phase 1 trial tested whether a dye called indocyanine green (ICG) can make brain tumor cells glow during surgery, helping surgeons see and remove them more completely. 363 adults with brain tumors received an ICG injection before surgery, and special cameras captur…

This study tested a drug called 5-ALA in 78 children with brain tumors. The drug makes tumor cells glow under a special light during surgery, helping surgeons remove more of the tumor while avoiding healthy brain. The main goal was to check if the drug is safe for children. Resea…

This early-phase trial tested the safety of adding two drugs, pembrolizumab and vorinostat, to standard chemotherapy and radiation for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study enrolled 21 participants to find the highest safe dose of vorinos…

This study is testing a new MRI technique called magnetic resonance fingerprinting (MRF) to see if it can improve how doctors diagnose and assess brain tumors. Researchers will compare MRF scans with standard tests, clinical details, and biopsy results in 172 people with brain tu…

This study tested a new, fast MRI sequence called Neuromix in 32 children with suspected or confirmed brain tumors. The goal was to see if the quick scan works as well as the standard, longer MRI. If it does, it could make scanning easier and less stressful for children.

This study looked at whether a special type of PET scan (using a tracer called FET) can accurately tell the difference between a returning brain tumor (glioma) and harmless changes caused by previous treatment. Researchers analyzed scans from 253 patients of all ages who had alre…

This study tested a special PET scan tracer called FLT in 50 adults with brain tumors (gliomas or metastases). The goal was to see if FLT-PET can measure how fast tumor cells are growing, which could help doctors diagnose and predict tumor behavior better than current scans like …

This study tested whether a special dye called fluoroethyltyrosine (FET) can improve PET scans for detecting brain tumors that have come back. 143 people with suspected recurrent brain tumors received an injection of FET before their PET scan. The goal was to see if FET-PET could…

This early study tested a new imaging technique that combines a special tracer ([18F]PARPi) with PET and MRI scans to get clearer pictures of brain tumors. Five adults with new or suspected returning brain tumors took part. The goal was to see how well the tracer highlights tumor…

This completed Phase 3 trial tested whether Elucirem (gadopiclenol) provides better MRI images of brain gliomas compared to the standard contrast agent Dotarem. 138 adults with primary or recurrent brain tumors received one of the two agents during DSC-MRI perfusion scans. The ma…

This study tested a machine learning tool that uses routine medical data to predict pneumonia risk within the first week after brain tumor surgery. Researchers included over 1,800 adults having their first planned brain tumor removal. The goal was to see if the AI could help doct…

This study tested a new MRI contrast agent called RVP-001, made with manganese instead of gadolinium, in 18 adults with known brain lesions (like tumors or multiple sclerosis). The goal was to see if it is safe and can detect lesions as well as current gadolinium-based dyes. Each…

This study looked at whether a type of PET scan called FDOPA-PET can help doctors tell the difference between brain tumors and non-cancerous brain lesions. Researchers reviewed scans from 74 patients with suspected brain tumors. They measured how much of the tracer the lesions to…

Researchers tested an artificial intelligence program that analyzes retinal images to diagnose several nerve and brain conditions, such as optic neuropathy and brain tumors. The study used data from 693 patients with confirmed diagnoses. The goal is to create a fast triage tool f…

This study tested whether a 12-week physical activity program could improve memory and attention in children who had radiation for brain tumors. Thirty-six kids aged 8–17 who finished radiation at least a year ago took part. Half started the program right away, while the other ha…

This study tested whether a computer-based cognitive training program could help children with brain tumors who had radiation therapy. 45 children were randomly assigned to either an adaptive or non-adaptive training program. The goal was to see if the training could improve thin…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tested a preventive skin care routine in 14 children (ages 6 months to 18 years) with brain tumors who were receiving targeted therapy (BRAF, MEK, or Pan-RAF inhibitors). The goal was to see if gentle skin care and sun protection could reduce or prevent skin reactions …

After brain tumor surgery, some patients develop lung issues like pneumonia. This study tested a new nursing system that includes breathing exercises, early movement, and team care. In 165 patients, the new system reduced lung complications from 13.6% to 4.8% and helped patients …

This study tested whether giving melatonin along with the sedative dexmedetomidine could lower the chance of post-operative delirium (confusion) after open brain surgery. 100 adults aged 30-60 took part. The goal was to see if the combination works better than dexmedetomidine alo…

This pilot study tested a telehealth program called C-SMART for people with primary brain tumors who have mild memory or thinking problems. The program combines cognitive rehabilitation with mindfulness training over 8 weekly sessions. Researchers enrolled 32 patients and caregiv…

This study tested a therapy called Managing Cancer and Living Meaningfully (CALM) to see if it helps people with brain cancer feel less distressed. 60 adults with brain tumors or brain metastases who had high depression or death anxiety took part. The study measured how many peop…

This study tested whether watching 360° virtual reality movies can reduce fear and anxiety in cancer patients about to start radiation therapy. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched a VR movie and then filled …

This completed study enrolled over 1,200 people with brain or spinal cord tumors to collect medical information, blood samples, and tumor tissue. The goal was to better understand these cancers and identify promising areas for future research. Participants also received guidance …

This study looks at long-term hormone and metabolic problems in people who survived a childhood brain tumor. Researchers will check survivors for issues like growth, thyroid, and blood sugar problems, and see how these relate to the tumor and its treatment. The goal is to help do…

This study tests a new graphene-based electrode array used during brain tumor surgery to map brain activity. Ten participants will have the device used alongside standard monitoring to check its safety and how well it records brain signals. If awake during surgery, they may do si…

This study investigates which parts of the brain help us judge when a moving object will reach us, a skill used in daily life. Researchers test patients during awake brain surgery for tumor removal, using a simple task where they estimate when a disappearing object would have mad…

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This study tested whether a detailed genetic analysis of tumor tissue could find treatment targets in 80 children with recurrent or very high-risk brain tumors. The goal was to see if this approach is practical and can help doctors choose personalized therapies. No new drugs were…

This completed study enrolled 84 people with brain tumors, meningioma, or high-grade sarcoma who received proton beam therapy. Researchers analyzed tumor and blood samples to find biomarkers that might predict how well the cancer responds to treatment. The goal is to eventually h…

This study looked back at medical records of 41 patients who had surgery for aggressive brain tumors (high-grade gliomas). Some surgeries used fluorescent dyes that make tumor tissue glow, helping surgeons tell it apart from healthy brain. The goal was to see if using these dyes …

This study explored whether a nutritional index (PNI) can predict death and other complications after brain tumor surgery. Researchers analyzed data from over 3,200 adults who had surgery at a major hospital in South Korea. The goal was to see if this simple blood-based score cou…

This study looked at how children who survived brain tumors interact with others. Researchers tested their thinking and social skills to see what helps or hurts their friendships. The goal was to learn more, not to test a new treatment.

This study looked at whether online training can improve how well emergency department doctors interpret CT head scans. 173 clinicians from 6 UK hospitals took part. One group received training early, while a control group got it later. The goal was to see if training boosts accu…

This study followed 155 children with brain or central nervous system tumors who received proton radiation therapy at Massachusetts General Hospital. Researchers measured changes in thinking skills, behavior, and use of special education services one year or more after treatment.…

This pilot study tested a new maskless immobilization device (MID) for patients with head and neck cancers or brain tumors undergoing radiation therapy. The goal was to see if the device could keep patients as still and accurate as the standard thermoplastic mask. Only 12 patient…

This first-in-human study tested a new soft neural probe in 5 adults already scheduled for brain surgery to remove a tumor or epileptic tissue. The probe was inserted into the part of the brain being removed to see if it could be placed safely and record electrical signals. Parti…

This study looked at how radiation therapy for pediatric brain cancer affects memory and brain structure in children, teens, and young adults. Researchers used MRI scans and memory tests to compare 60 participants. The goal is to better understand which brain areas are harmed by …

This study tested a new, highly sensitive ultrasound technique to map brain activity during surgery in 23 adults with brain tumors or lesions. The method aims to provide real-time images of blood flow changes linked to brain function, without needing contrast agents. Researchers …