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Brain games for young cancer survivors: a promising pilot study

NCT ID NCT01503086

Symptom relief Sponsor: Children's Oncology Group Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This study tested whether a computer-based cognitive training program could help children with brain tumors who had radiation therapy. 45 children were randomly assigned to either an adaptive or non-adaptive training program. The goal was to see if the training could improve thinking skills and quality of life. The study focused on whether children could complete enough training sessions to potentially see benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Jul 2014

Finished

Mar 2026

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 16 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must be newly diagnosed or relapsed/progressed with a brain tumor that has not previously been treated with CRT * Note: COG therapeutic study participation is not required for ACCL10P1 enrollment * Patient enrollment must occur within 4 calendar months following completion of CRT * Reminder: after patient enrollment, baseline testing followed by randomization must occur within 2-4 months after completion of CRT * The patient must have an identified caregiver who is willing and able to oversee the training practice during the intervention period (ie, for 5-9 weeks starting approximately 3 months after completion of CRT) * The patient must have access to a telephone and phone number where they can be reached * The patient and caregiver must have reading, speaking and listening comprehension of English * All patients and/or their parents or legal guardians must sign a written informed consent (patient assent is also recommended when applicable according to each institution's policy) * All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met Exclusion Criteria: * Patients with pontine glioma are not eligible * Patients with an estimated survival of less than one year are not eligible * Patients with a history of traumatic brain injury prior to tumor diagnosis are not eligible * Patients with a motor, visual, or auditory handicap that prevents computer use (e.g., unresolved posterior fossa syndrome) are not eligible to participate in this trial * Patients with full-scale intelligence quotient (IQ) \< 70 per previous testing OR existing diagnosis of/educational classification as a student with an intellectual disability are not eligible

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm primary brain neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain neoplasm Recurrent brain neoplasm

Contacts and locations

Locations

  • Albany Medical Center

    Albany, New York, 12208, United States

  • Alfred I duPont Hospital for Children

    Wilmington, Delaware, 19803, United States

  • Blank Children's Hospital

    Des Moines, Iowa, 50309, United States

  • Broward Health Medical Center

    Fort Lauderdale, Florida, 33316, United States

  • C S Mott Children's Hospital

    Ann Arbor, Michigan, 48109, United States

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Mercy Hospitals and Clinics

    Kansas City, Missouri, 64108, United States

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • East Tennessee Childrens Hospital

    Knoxville, Tennessee, 37916, United States

  • Golisano Children's Hospital of Southwest Florida

    Fort Myers, Florida, 33908, United States

  • Hospital for Sick Children

    Toronto, Ontario, M5G 1X8, Canada

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Nemours Children's Clinic-Jacksonville

    Jacksonville, Florida, 32207, United States

  • Nemours Children's Hospital

    Orlando, Florida, 32827, United States

  • Providence Sacred Heart Medical Center and Children's Hospital

    Spokane, Washington, 99204, United States

  • Saint Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • Tampa General Hospital

    Tampa, Florida, 33606, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.