Children's Oncology Group

This study tests whether adjusting treatment based on each child's specific risk of relapse can improve cure rates for Wilms tumor, a common childhood kidney cancer. About 1,656 children with favorable histology Wilms tumor will receive therapy matched to their tumor's features a…

This study looks at two groups of people with germ cell tumors. For those with low-risk tumors that haven't spread, doctors will simply monitor them closely after surgery instead of giving extra treatment. For standard-risk patients whose tumors have spread, the study compares tw…

This study is for people aged 3 to 29 with a rare type of brain tumor called non-germinomatous germ cell tumor that hasn't spread. The goal is to see if giving radiation based on how well the tumor shrinks after initial chemo can reduce side effects and prevent the cancer from co…

This study tests a drug called tegavivint in children, teens, and young adults (ages 1 to 30) whose solid tumors have returned or not responded to standard therapy. The drug works by blocking a key signal that tells cancer cells to grow. The trial aims to find the safest dose, un…

This study tests two powerful chemotherapy combinations in children with a rare, aggressive kidney cancer called Wilms tumor. The goal is to see if these drug mixes can stop the cancer from growing or coming back. About 256 children with newly diagnosed or relapsed Wilms tumor wi…

This study compares two surgical methods to remove osteosarcoma that has spread to the lungs: open surgery (one large cut) and keyhole surgery (several small cuts with a camera). About 62 people under age 50 with up to 4 lung nodules will take part. The goal is to see which appro…

This early-stage study tests a new drug called imetelstat combined with two chemotherapy drugs (fludarabine and cytarabine) in children and young adults up to age 18 whose leukemia (AML, MDS, or JMML) has returned or not responded to treatment. The main goal is to find the safest…

This study tests a new drug combination (DT2216 plus irinotecan) in children, teens, and young adults whose solid tumors have returned or not responded to treatment. The goal is to find the safest dose and see if the combination can shrink tumors. The study includes a special gro…

This study tests whether giving triptorelin before chemotherapy can protect the ovaries of young women (under 40) with cancer. Chemotherapy drugs called alkylating agents can harm the ovaries, making it hard to get pregnant later. Triptorelin temporarily pauses ovary activity to …

This study is for children and young adults (ages 3-29) with a type of brain tumor called germinoma. Researchers want to see if giving a lower dose of radiation after chemotherapy can still control the tumor while causing fewer long-term side effects. About 240 participants will …

This study tests whether new drug combinations work better than standard therapy for children and young adults with newly diagnosed acute myeloid leukemia (AML). About 1,186 participants will receive either standard chemo plus gemtuzumab ozogamicin, or a newer drug called CPX-351…

This large phase 3 study is testing whether adding a targeted drug called inotuzumab ozogamicin to standard chemotherapy and immunotherapy can improve outcomes for children and young adults with high-risk B-cell acute lymphoblastic leukemia (B-ALL). The drug works like a guided m…

This study tests a drug called CBL0137 in children and young adults (ages 1 to 21) whose solid tumors, brain tumors, or lymphoma have returned or stopped responding to treatment. The goal is to find the safest dose and see if the drug can shrink tumors by blocking signals that he…

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens after a stem cell transplant. About 105 participants aged 2 to 17 who are CMV-positive will receive letermovir to see if it lowers infection rates compared to …

This study is for children with a type of brain cancer called medulloblastoma. It tests if a drug called sodium thiosulfate can reduce hearing loss caused by chemotherapy. It also tests if children with a lower-risk form of the cancer can receive less intense radiation without af…

This study tests whether adding a radioactive drug (131I-MIBG) or a targeted pill (lorlatinib) to standard therapy helps children with high-risk neuroblastoma live longer without the cancer coming back. About 750 children and young adults (ages 1 to 30) with newly diagnosed high-…

This study looks at whether a drug called dexrazoxane can help prevent heart problems in children and teens who have been treated for certain cancers like leukemia or lymphoma. Researchers will check blood samples and heart scans from about 420 survivors to see how well the drug …

This study tests a drug called inotuzumab ozogamicin in children and young adults (ages 1-21) whose B-cell acute lymphoblastic leukemia (B-ALL) has returned or not responded to standard treatment. The drug works like a smart bomb: it attaches to a protein (CD22) on leukemia cells…

This study is for children and young adults with a newly diagnosed, low-risk type of muscle cancer called rhabdomyosarcoma. The goal is to see if a shorter course of two chemotherapy drugs (vincristine and dactinomycin) works just as well for very low-risk patients, while also te…

This study tests if adding a drug called melphalan (given as an injection into the eye) to standard chemotherapy can better treat retinoblastoma, a rare eye cancer in children. The trial focuses on cases with 'vitreous seeds'—cancer cells floating in the eye's jelly-like fluid. A…

This early-stage trial is testing a new drug called AZD1390 combined with radiation therapy in children and young adults with aggressive brain tumors (high-grade glioma, diffuse midline glioma, or DIPG). The drug works by blocking the cancer cells' ability to repair damage caused…

This study looks at the best way to treat a rare childhood lung tumor called pleuropulmonary blastoma (PPB). For early-stage (type I) tumors, it compares surgery alone to surgery followed by chemotherapy to see if chemo is needed. For more advanced (types II and III) tumors, it t…

This study tests if a home-based exercise program designed for Hispanic and Latino/Latina teens and young adults who survived childhood cancer can help them be more active. Participants will use a Fitbit and get support through social media. The goal is to improve physical fitnes…

This study collects health information and leftover tumor or blood samples from children and young adults with cancer. The goal is to learn more about these diseases and find better ways to treat and care for patients over time. Up to 75,000 people will take part, and no experime…

This study looks at how certain blood cell changes (called clonal hematopoiesis) after Hodgkin lymphoma treatment might be linked to later heart problems. Researchers will test blood samples from 190 survivors who received chemotherapy as children or young adults. The goal is to …

This study follows over 1,100 children and teens diagnosed with germ cell tumors to learn about short- and long-term side effects from treatment, especially hearing loss. Researchers will also analyze tumor genetics to find patterns that could better predict which patients need m…

This study examines stored umbilical cord blood from 300 children who later developed leukemia. Researchers will check the cord blood for the same genetic changes found in the children's leukemia cells. The goal is to understand how and when these changes first appear before birt…

This study looks at 50 twins where only one has a childhood brain tumor. Researchers will compare DNA from blood and saliva samples to find small genetic differences that might explain why one twin got sick. The goal is to better understand what causes these cancers, not to test …

This study looks at the long-term health of children and young adults with Down syndrome who have been treated for acute leukemia. Researchers want to understand what chronic health problems they may face after cancer treatment. By gathering this information, they hope to create …