Children's Oncology Group

This study tests whether adding daratumumab (a drug that helps the immune system attack cancer cells) to standard chemotherapy can improve outcomes for children and young adults with newly diagnosed T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma. About 1,700…

This study compares two chemotherapy approaches for people with newly diagnosed intermediate-risk rhabdomyosarcoma, a type of muscle cancer. One group gets a higher dose of chemo over a shorter time, while the other gets a lower dose over a longer time plus maintenance therapy. B…

This study tests whether a new type of PET scan (18F-MFBG) can find neuroblastoma tumors as well as or better than the current standard scan (123I-MIBG). About 84 children and adults with newly diagnosed, high-risk neuroblastoma will receive both scans at different times. The goa…

This study tests whether dental wipes containing xylitol, a natural sugar that limits bacteria growth, can reduce bloodstream infections in children with acute myeloid leukemia (AML). About 556 children and young adults (ages 1-25) will use either xylitol wipes or plain wipes dur…

This study looks at how access to care, hospital experiences, and stress affect the quality of end-of-life care for children with cancer. Researchers will study data from about 1,190 children who have passed away and talk to their parents. The goal is to find ways to identify fam…