Children's Oncology Group

This study tested whether adding an extra drug combination (topotecan, vincristine, and cyclophosphamide) to the usual 5-drug chemotherapy could improve outcomes for children and teens with Ewing sarcoma that had not spread. A total of 642 participants were randomly assigned to r…

This study tested a combination of a drug (rituximab) and specially trained immune cells (LMP-T cells) in 18 children who developed a rare cancer (PTLD) after an organ transplant. The goal was to see if this approach was feasible and could help control the disease. The treatment …

This study looked at two different chemotherapy plans for children under 3 with aggressive brain tumors. One plan included a drug called methotrexate, the other did not. Both plans were followed by a stem cell transplant. The goal was to see which plan worked better at shrinking …

This study tested a very strong treatment plan for children newly diagnosed with high-risk neuroblastoma, a rare nerve tissue cancer. It combined intensive chemotherapy, a radioactive drug called 131I-MIBG, and a stem cell transplant to kill as many cancer cells as possible. The …

This study tested whether giving chemotherapy first, then a lower dose of radiation, could safely treat children and teens with newly diagnosed central nervous system germ cell tumors that hadn't spread. 262 participants received chemotherapy drugs (carboplatin, etoposide, ifosfa…

This study tested two methods to help children with acute lymphoblastic leukemia (ALL) take their daily chemotherapy pill (mercaptopurine) as prescribed. About 570 children in remission were assigned to either an educational program or a more intensive intervention. The goal was …

This study looked at whether giving chemotherapy after surgery and radiation helps children with a rare brain tumor called ependymoma live longer without the cancer coming back. It included 479 children aged 1 to 21. The results showed that adding chemo did not clearly improve ou…

This study tested whether a computer-based cognitive training program could help children with brain tumors who had radiation therapy. 45 children were randomly assigned to either an adaptive or non-adaptive training program. The goal was to see if the training could improve thin…

This study followed nearly 4,000 childhood cancer survivors to understand why some develop serious health problems years later, such as heart failure, stroke, or a second cancer. Researchers looked at patients' genes and medical history to find clues about who is at higher risk. …

This study collected tumor tissue, blood, and urine samples from 8,000 children and young adults with kidney tumors. The goal was to store these samples for future research to find DNA changes and biomarkers linked to cancer. No new treatments were tested; instead, the study focu…