Children's Oncology Group

This study aimed to find the best chemotherapy treatment for very young children (under 3 years old) with newly diagnosed, high-risk brain tumors. Researchers compared two intense drug combinations—one with a drug called methotrexate and one without—to see which was more effectiv…

This study tested whether doctors could safely use a lower dose of radiation therapy to treat children and young adults with specific types of brain tumors. The goal was to see if this approach could still effectively control the cancer while potentially reducing long-term side e…

This study tested whether an intensive, multi-step treatment approach was feasible for children and young adults with newly diagnosed high-risk neuroblastoma. The treatment involved several rounds of chemotherapy, a targeted radiation therapy, a stem cell transplant, and ongoing …

This large, completed study tested whether adding a new combination of three chemotherapy drugs (vincristine, topotecan, and cyclophosphamide) to the standard five-drug treatment would help children and young adults with localized Ewing sarcoma live longer without their cancer re…

This study tested a two-part treatment for children and young adults who developed a specific type of cancer after an organ transplant. The cancer is linked to the Epstein-Barr virus. Researchers combined a standard antibody drug (rituximab) with specially trained immune cells de…