Children's Oncology Group

This study tests different combinations of chemotherapy drugs, along with surgery, for children and young adults with two types of liver cancer: hepatoblastoma and hepatocellular carcinoma. The goal is to see which combinations work best to stop tumor growth and improve survival.…

This study tests a new oral drug (revumenib) combined with standard chemotherapy for infants and young children with a specific type of leukemia (KMT2A-rearranged) that has returned or not responded to treatment. The goal is to see if the combination is safe and works better than…

This study tests a personalized approach for children with non-high-risk neuroblastoma, where treatment is guided by the tumor's biology and how it responds over time. Some children may only need monitoring instead of immediate therapy, potentially avoiding harsh side effects. Th…

This early-phase trial is testing a drug called flotetuzumab in children and young adults with acute myeloid leukemia (AML) that has returned or not responded to standard treatment. Flotetuzumab is an immunotherapy designed to help the body's immune cells find and attack cancer c…

This study tests a new drug called DT2216 combined with the chemotherapy irinotecan in children, teens, and young adults whose solid tumors have come back or not responded to treatment. The goal is to find the safest dose and see if the combination can shrink tumors, especially i…

This study tests whether adding three drugs (vincristine, irinotecan, and regorafenib) to standard chemotherapy can help people with Ewing sarcoma that has spread. About 437 participants will receive either the new combo or standard treatment. The goal is to see if the new approa…

This phase 3 trial is testing whether adjusting chemotherapy based on a child's early response can improve outcomes for acute myeloid leukemia (AML) or myelodysplastic syndrome in children with Down syndrome. After the first round of treatment, patients are placed into risk group…

This phase 3 trial tests imatinib, a targeted cancer drug, with two different chemotherapy backbones in children and adolescents with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The goal is to see if a less intense chemo regimen works as well as the s…

This study tests a new drug called AZD1390 given alongside radiation therapy for children with aggressive brain tumors (high-grade glioma, DIPG, or DMG). The drug blocks cancer cells from repairing damage caused by radiation, potentially making treatment more effective. About 54 …

This study tests a drug called nirogacestat in children and teens with desmoid tumors that have grown despite treatment and cannot be surgically removed. The goal is to see if the drug can stop or slow tumor growth and to check for side effects. About 31 participants aged 1 to 18…

This phase 3 trial compares two types of stem cell transplants for children, adolescents, and young adults with acute leukemia or myelodysplastic syndrome (MDS). One uses a half-matched family donor (haploidentical), the other a fully matched unrelated donor. The goal is to see w…

This study tests a drug called inotuzumab ozogamicin in children and young adults (ages 1 to 21) whose B-cell acute lymphoblastic leukemia (B-ALL) has returned or not responded to standard treatment. The drug works like a guided missile, attaching to a marker (CD22) on cancer cel…

This study tests whether adding a drug called vinorelbine to standard chemotherapy can better control high-risk rhabdomyosarcoma, a rare and aggressive muscle cancer in children and young adults. About 118 participants will receive either the standard treatment or the new combina…

This phase 2 trial is testing whether giving lower doses of radiation and chemotherapy can effectively treat a specific type of brain tumor called WNT-driven medulloblastoma in children and young adults aged 3 to 21. The goal is to kill cancer cells while reducing long-term side …

This study looks at whether children with chronic myeloid leukemia (CML) who have very low levels of disease can stop taking their daily tyrosine kinase inhibitor (TKI) medication and still stay in remission. About 110 children will stop their TKIs and be closely monitored. If th…

This early-stage trial tests a new treatment for children whose ependymoma brain tumor has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to recognize and attack tumor cells that carry a protein called HER2. Th…

This early-phase study tests a vaccine called SurVaxM in 35 children with certain brain tumors that have come back or are hard to treat. The vaccine is designed to teach the immune system to find and destroy tumor cells that have a protein called survivin. The goal is to see if i…

This study tests the Optune device, a wearable cap that creates low-intensity electric fields to disrupt cancer cell growth, in children with aggressive brain tumors. One group of children with recurrent high-grade glioma or ependymoma will use the device alone to see if it's fea…

This study was designed to test the safety and best dose of the drug revumenib in children and young adults with certain types of leukemia (ALL, AML, or mixed phenotype) after they have received a stem cell transplant. The goal was to see if revumenib could help prevent the cance…

This phase III trial tests a combination of arsenic trioxide and tretinoin (a vitamin A derivative) in 158 people with newly diagnosed acute promyelocytic leukemia (APL). The goal is to see if this drug pair can replace high-dose anthracycline chemotherapy, which can cause long-t…

This study tests whether adding eflornithine (DFMO) to a standard chemotherapy and immunotherapy regimen can improve outcomes for children with neuroblastoma that has returned or is not responding to treatment. About 94 children will be randomly assigned to receive the standard t…

This study looks at a drug called enasidenib for children and teens with acute myeloid leukemia (AML) that has come back or is hard to treat. The drug targets a specific genetic change (IDH2 mutation) found in their cancer cells. The main goals are to check the drug's safety and …

This study tests a drug called larotrectinib in children and young adults (up to age 30) with certain cancers that have a specific genetic change called a TRK fusion. The goal is to see if the drug can shrink solid tumors or control leukemia that has returned. The drug works by b…

This study tests whether adding two chemotherapy drugs (irinotecan and temozolomide) to the standard immunotherapy regimen (dinutuximab, GM-CSF, isotretinoin) can safely prevent high-risk neuroblastoma from returning after intensive initial therapy. About 41 children and young ad…

This study tests the drug bosutinib in 60 children with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Some children are newly diagnosed, while others have not responded to or cannot tolerate other treatments. The goal is to find the best dose and see if the…

This study tests whether a new type of PET scan (18F-MFBG) can detect neuroblastoma tumors as accurately as the current standard scan (123I-MIBG). About 84 children and adults with newly diagnosed, high-risk neuroblastoma will receive both scans to compare results. If the new sca…

This study tests whether a probiotic called Lactobacillus plantarum can prevent a serious complication called graft-versus-host disease (GvHD) in the gut of children receiving a donor stem cell transplant. About 173 children with blood cancers or other conditions are taking the p…

This study tests whether adding levocarnitine, a natural nutrient, to standard chemotherapy can prevent severe liver damage in teens and young adults (ages 15-39) with leukemia or lymphoma. About 440 participants will receive either chemotherapy alone or chemotherapy plus levocar…

This study tests whether memantine, a drug used for Alzheimer's, can protect memory and thinking in children aged 4-17 receiving brain radiation for central nervous system tumors. About 192 participants will receive either memantine or a placebo during and after radiation. The go…

This study looks at whether a mobile health program combined with social media can help teens and young adults who survived childhood cancer become more physically active. About 387 participants will either use the program plus a fitness tracker or just the tracker alone. The goa…

This study follows 549 children, teens, and young adults with cancer to see how their immune systems respond to COVID-19 vaccines. Researchers collect blood samples to measure protective antibodies. The goal is to learn how cancer and its treatment affect vaccine effectiveness, a…

This long-term study follows 5,000 childhood cancer survivors who had a stem cell transplant or treatment for leukemia or solid tumors. Researchers collect health updates and quality-of-life questionnaires over 20+ years to understand late effects of therapy. The goal is to reduc…

This study looks at 1,000 children who have both a birth defect and cancer, along with their parents. Researchers will analyze DNA from saliva and blood samples to find genetic changes that might explain why these conditions occur together. The goal is to improve cancer risk mana…

This study looks at a new method for giving the cancer drug vincristine to infants and young children. The goal is to see if this new way of calculating the dose leads to similar drug levels in the blood as the standard method used in older children. About 83 children up to 12 ye…

This study explores genetic mutations in children with embryonal or alveolar rhabdomyosarcoma by analyzing saliva or cheek cell samples from the child and their parents. The goal is to identify inherited or new gene changes that may help doctors predict how the disease will progr…

This study investigates how inherited genetic variations, especially in the SMAD6 gene, influence a person's risk of developing Langerhans cell histiocytosis (LCH), a rare disease where immune cells build up in tissues. Researchers will collect saliva or cheek swabs from 647 chil…

This study looks at how worried parents are about money while their child is being treated for acute lymphoblastic leukemia. Researchers will survey 100 parents over time to see how financial distress changes and what factors make it better or worse. The goal is to gather informa…

This research study follows 376 survivors of high-risk neuroblastoma to see what long-term side effects they experience from their past treatments. By collecting blood, urine, and quality-of-life data, researchers hope to learn which therapies cause fewer late health problems lik…

This study is a large registry that collects information from children diagnosed with cancer across the US and Canada. Its goal is to help researchers understand patterns, causes, and characteristics of childhood cancer. No treatments or drugs are given—it is purely for research …