Children's Oncology Group

This study compares two types of stem cell donors for children, teens, and young adults with high-risk leukemia or myelodysplastic syndrome (MDS). Participants receive a stem cell transplant from either a partially matched family donor or a fully matched unrelated donor. The goal…

This study tests how well combining chemotherapy with or without radiation works for children and young adults (under 30) newly diagnosed with stage III or IV Wilms tumor, a type of kidney cancer. The goal is to see if these treatments can prevent the cancer from coming back. Abo…

This study tests different combinations of chemotherapy drugs in children and young adults with liver cancer (hepatoblastoma or hepatocellular carcinoma). The goal is to see which combinations work best alongside surgery to stop tumors from growing or spreading. About 537 partici…

This early-phase trial tests a drug called flotetuzumab in children, teens, and young adults whose acute myeloid leukemia (AML) has returned or not responded to standard treatment. The drug works by helping the immune system attack leukemia cells. The main goals are to find the s…

This study tests whether adding two chemotherapy drugs (irinotecan and temozolomide) to the standard immunotherapy regimen (dinutuximab, GM-CSF, and isotretinoin) can safely prevent high-risk neuroblastoma from returning after intensive initial therapy. About 41 children and youn…

This study tests a new oral drug (revumenib) combined with chemotherapy for infants and young children with a hard-to-treat leukemia that has returned or not responded to treatment. The drug targets a specific genetic change (KMT2A rearrangement) that drives the cancer. The goal …

This study looks at whether giving lower doses of radiation and chemotherapy to children with a specific, less-aggressive type of brain tumor (WNT medulloblastoma) can still cure the cancer while causing fewer long-term problems like learning issues or hormone imbalances. About 4…

This study looks at how well different treatments work for children with a type of kidney cancer called Wilms tumor. After surgery, some children get chemotherapy drugs (vincristine, dactinomycin, doxorubicin) with or without radiation, while others are simply watched to see if t…

This phase III study tests whether combining two drugs—tretinoin and arsenic trioxide—can effectively treat newly diagnosed acute promyelocytic leukemia (APL) without the need for standard chemotherapy that can damage the heart. The trial includes 158 patients and aims to see if …

This study tests a drug called nirogacestat in children and teens with desmoid tumors that have grown despite prior treatment and cannot be surgically removed. The goal is to see if the drug can stop or slow tumor growth and to check for side effects. About 31 participants aged 1…

This study tests whether using the tumor's biology and how it responds to treatment can guide therapy for children with non-high-risk neuroblastoma. Some children may only need monitoring instead of immediate treatment, which could avoid unnecessary side effects. The trial enroll…

This study looks at whether children with chronic myeloid leukemia (CML) who have had very low disease levels for at least two years can stop taking their daily targeted therapy (tyrosine kinase inhibitors) and still stay in remission. About 110 children are enrolled to see how m…

This study tests whether adding three drugs (vincristine, irinotecan, regorafenib) to standard chemotherapy helps people with newly diagnosed Ewing sarcoma that has spread. About 437 participants aged 1 to 50 will receive either the new combo or standard treatment. The goal is to…

This study tests a cancer vaccine called SurVaxM in 35 children whose brain tumors have come back or are hard to treat. The vaccine teaches the immune system to find and destroy tumor cells. The goal is to see if it is safe and helps control the disease.

This study looks at the best way to treat children with a slow-growing type of Hodgkin lymphoma called LPHD. It compares surgery alone, chemotherapy with or without radiation, or just watching and waiting. The goal is to find treatments that work well while reducing side effects.

This study looks at a drug called enasidenib for children and teens with acute myeloid leukemia (AML) that has returned or not responded to standard treatment. Only patients with a specific genetic change (IDH2 mutation) are included. The goal is to check the drug's safety and ho…

This study tests whether adding levocarnitine, a natural nutrient, to standard chemotherapy can prevent severe liver damage in teens and young adults (ages 15-39) with leukemia or lymphoma. Liver toxicity from the chemo drug asparaginase often delays treatment, especially in cert…

This early-stage study tests a treatment called HER2 CAR T cells in up to 50 children whose ependymoma brain tumor has come back or not responded to standard care. The cells are made from each child's own blood and trained to recognize and attack the tumor. The main goals are to …

This study tests a drug called larotrectinib in children and young adults up to age 30 who have certain cancers (solid tumors or leukemia) with a specific genetic change called a TRK fusion. The goal is to see if the drug can shrink tumors or control the cancer. About 33 particip…

This study tests a targeted cancer drug (imatinib) with two different chemotherapy plans in children and teens newly diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The goal is to see if a milder chemo regimen works just as well as a strong…

This study is testing a drug called bosutinib in children with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). The goal is to find the best dose and see if it is safe and works for children who are newly diagnosed or whose cancer has not responded to other tr…

This study tests whether adding a drug called vinorelbine to standard chemotherapy can help children and young adults with high-risk rhabdomyosarcoma, a rare muscle cancer. About 118 participants will receive either the standard treatment or the new combination, followed by maint…

This study tests whether adding a drug called eflornithine (DFMO) to a standard treatment (irinotecan, temozolomide, and dinutuximab) helps children with neuroblastoma that has come back or is not responding to treatment. About 94 children will be randomly assigned to receive the…

This study looks at whether a wearable device called Optune is safe and practical for children with aggressive brain tumors. In one group, kids with recurrent high-grade glioma or ependymoma use the device alone. In another group, children with newly diagnosed DIPG use the device…

This study was designed to test the safety and best dose of a drug called revumenib in children with certain types of leukemia after they had a stem cell transplant. The goal was to see if revumenib could help prevent the cancer from returning. However, the trial was withdrawn be…

This large phase 3 study is testing different combinations and doses of chemotherapy drugs in over 9,000 children and young adults newly diagnosed with standard-risk B-cell acute lymphoblastic leukemia or localized B-cell lymphoblastic lymphoma. The goal is to find which treatmen…

This study tests whether a probiotic called Lactobacillus plantarum can prevent a serious gut condition called graft-versus-host disease (GvHD) in children receiving a donor stem cell transplant. About 173 children with blood cancers or other blood disorders are taking part. The …

This study tests whether memantine, a drug used for Alzheimer's, can protect memory and thinking in children aged 4-17 receiving brain radiation for central nervous system tumors. About 192 participants will receive either memantine or a placebo during radiation. The goal is to s…

This study follows up to 5,000 children and teens who have had cancer or a stem cell transplant. Researchers collect health information over many years to learn about long-term side effects of treatment. The goal is to reduce future health problems and improve quality of life for…

This study tracks how financial distress (worry about money) changes for parents of children aged 1 to 14 being treated for acute lymphoblastic leukemia. Researchers will survey 100 parents over time to understand what factors, like income or hospital policies, affect these money…

This study follows 376 people who survived high-risk neuroblastoma to see what long-term health problems they face, like organ damage, growth issues, or learning difficulties. The goal is to learn which treatments cause fewer side effects over time, helping doctors choose better …

This study looks at how inherited genes may make some children more likely to develop Langerhans cell histiocytosis (LCH), a rare disease where immune cells grow out of control. Researchers will analyze DNA from 647 children and their parents to find gene changes linked to LCH an…

This study creates a large registry to collect information from nearly 58,000 children diagnosed with cancer or similar conditions in the U.S. and Canada. The goal is to help researchers study patterns, causes, and characteristics of childhood cancer. Parents provide details abou…

This study tracks how the immune systems of children, teens, and young adults with cancer respond to COVID-19 vaccines. Cancer and its treatments can weaken immunity, so researchers want to see if factors like vaccine type, timing, and booster shots affect protection. About 549 p…

This study collects saliva or cheek cell samples from 900 children with a rare muscle cancer called rhabdomyosarcoma, along with samples from their parents. Researchers look for genetic mutations that may be linked to the disease. The goal is to learn more about how these gene ch…

This study compares two ways to increase physical activity in teens and young adults who have finished cancer treatment. One group uses a mobile app and social media support, while the other just wears a fitness tracker. The goal is to see which approach helps them stay active an…

This research study looks at tumor tissue from children newly diagnosed with neuroblastoma or related tumors. By studying these samples, doctors hope to find biological markers that can predict how the disease will behave and help guide treatment decisions. The study does not tes…

This study looks at children who were born with a birth defect and later developed cancer. Researchers want to find out if there are shared genes that cause both conditions. They will collect DNA from up to 1,000 children and their parents to search for genetic clues. The goal is…

This study follows 1,200 children with cancer to understand how the disease and its treatments affect learning, memory, emotions, and behavior over time. Researchers collect data from tests and questionnaires to identify patterns and challenges. The goal is to gather knowledge th…

This study looks at whether lab results can be sent automatically from hospital computers to research databases, instead of being typed in by hand. Researchers will test this process at multiple hospitals to see if it saves time and reduces errors. About 118 participants' data fr…

This study compares a new dosing method for the cancer drug vincristine in infants and young children to the standard method used in older children. The goal is to see if the new approach gives similar drug levels in the blood with fewer side effects. About 83 children up to 12 y…