Arthropathy

Researchers are testing an experimental drug called sonelokimab in adults with active psoriatic arthritis, a condition that causes painful, swollen joints along with skin psoriasis. The trial compares sonelokimab injections with placebo injections, and also includes a third group…

This Phase 3 trial tested a single injection of TG-C, a cell-based treatment, in 531 people with moderate knee osteoarthritis. The goal was to see if it reduces pain and improves knee function compared to a placebo injection. Participants were followed for 24 months to check safe…

This trial investigates whether placing a kaolin-based clotting gauze inside the knee joint, combined with an intravenous dose of tranexamic acid, can reduce total blood loss during total knee replacement. About 140 adults with advanced knee osteoarthritis will be randomly assign…

This study looks at how well the SAGITTA EVL R hip implant works over the long term—7 to 10 years after surgery. Researchers are checking how many implants survive without needing another revision, how satisfied patients are, and what complications arise. The study includes adult…

This study compared four different knee replacement devices in 218 adults with knee arthritis to see which one patients 'forget' about most after surgery. The main goal was to measure how natural the joint feels using the Forgotten Joint Score. Results could help surgeons choose …

This study looked at how well a specific knee replacement (balanSys UNI) works over time. 116 people with knee arthritis got the implant and were followed for at least 2 years. Doctors measured knee function using the Knee Society Score and checked X-rays for any problems.

This study looked at a medical device used to fix bone deformities in children's legs, like knock-knees or bowlegs. Researchers checked the safety and how well the device worked in 69 children who had already been treated. The goal was to see if the device corrected the bone shap…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were randomly given either ibuprofen or a placebo. Researchers tracked serious problems like heart attack, stroke, blood clots, kidney failure, and bleedi…

This study tested an oral drug called upadacitinib (RINVOQ) against a placebo and an injected drug (adalimumab/Humira) in 1705 people with active psoriatic arthritis who had not responded well to standard non-biologic treatments. The goal was to see if upadacitinib reduces joint …

This phase 3 study tested upadacitinib, an oral anti-inflammatory drug, in 642 adults with active psoriatic arthritis who had not responded well to at least one biologic treatment. Participants received either 15 mg or 30 mg of upadacitinib daily or a placebo. The main goal was t…

This study followed 76 adults who received a total shoulder replacement using the MIRAI modular prosthesis. Researchers measured how well the shoulder functioned and how stable the implant was over five years. The goal was to see if the implant helps patients move better and last…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study looks at whether virtual reality (VR) therapy or a simple deep rest relaxation technique can help older adults feel less stressed and recover better after hip or knee replacement surgery. About 90 people aged 60 and older who recently had surgery will try one of these …

This study tests a device called RELAY that delivers both local anesthetic and mild electrical pulses to nerves after shoulder or foot surgery. The goal is to provide up to 28 days of pain relief, much longer than current options. About 50 adults undergoing specific surgeries wil…

This study tested whether a single injection of amniotic suspension allograft (ASA) can reduce pain and improve function in adults with knee osteoarthritis who haven't found relief from other treatments. About 594 participants received either ASA or a placebo, and their pain and …

This study looked at 60 people having knee replacement surgery to compare two types of nerve blocks for pain relief: the adductor canal block and the pericapsular nerve group block. The goal was to see which one provides better pain control and helps patients feel more comfortabl…

This study looked at whether doing physical therapy online (telerehabilitation) works as well as going to a clinic in person after shoulder replacement surgery. 93 patients were randomly assigned to either online or in-person therapy. Researchers measured shoulder movement, pain,…

This pilot study looked at whether passive static stretching can increase hip flexibility in three groups: people who had hip replacement, those with long-term hip pain, and healthy volunteers. Twelve participants followed a 4-week stretching program three times a week under supe…

This study looked at whether high-intensity laser therapy can reduce shoulder pain and improve movement in people who have had a stroke. Forty participants aged 50-85 with lasting shoulder pain after a stroke received the laser treatment. The goal was to see if it helps with pain…

This study tested whether a custom knee brace connected to a mobile app and motion sensors can improve symptoms and daily function for people with knee osteoarthritis. 36 adults aged 45-75 with mild to moderate knee OA wore their assigned brace for 6 months and completed surveys …

This study tested a program called OPERAS that includes a web app for tracking symptoms and a physiotherapist who gives activity advice using a Fitbit. The goal was to see if it helps people with rheumatoid arthritis feel more confident managing their disease. 132 adults with rhe…

This study tested a dietary supplement containing Boswellia serrata, curcumin, and MSM in 100 adults with joint pain or stiffness. Participants took either the supplement or a placebo for a period, and researchers measured inflammation markers and arthritis symptoms using a stand…

This study looked at whether manual therapy (hands-on treatment) and structured exercises could improve balance and walking ability in adults with hemophilia. Thirty-five adults with moderate or severe hemophilia took part. Half received 12 physiotherapy sessions over 6 weeks, wh…

This study tested different volumes of an ultrasound-guided nerve block (adductor canal block) to manage pain after total knee replacement. 90 adults scheduled for knee replacement under spinal anesthesia received one of two volumes. The goal was to see which volume reduces opioi…

This study compared two ways to manage pain after total hip replacement: a newer ultrasound-guided nerve block (PENG block) versus standard surgical infiltration. The goal was to see which method reduces the need for strong painkillers like morphine, especially in older patients …

This study tested whether manually mobilizing the sacroiliac joint (a joint in the lower back) can reduce tension and pain in the piriformis muscle, a deep hip muscle that often cramps. Researchers used physical therapy techniques on 40 adults with lower back or hip pain and musc…

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

This study tested a new device called RELAY that delivers both local anesthetic and mild electrical stimulation through a single catheter to control pain after shoulder or foot surgery. Twenty adults who had surgery for rotator cuff tears, shoulder replacement, or foot problems t…

This study tested whether an injection made from donated human amniotic tissue and cells (called ASA) can reduce pain and improve function in people with knee osteoarthritis. Over 500 adults with moderate to severe knee OA received either ASA or a placebo (salt water) injection. …

This study tested whether a Fitbit activity tracker, a smartphone app, and phone calls with a physical therapist could help people with knee osteoarthritis become more active and sit less. Fifty-one participants were split into two groups: one received the program right away, the…

This study compared robotic-assisted total knee replacement to the conventional technique in 95 patients with knee arthritis. The goal was to see if robotic surgery leads to better knee function, less pain, and higher satisfaction two years after the operation. Researchers also c…

Researchers at Nantes University Hospital are studying how joint damage from bleeding affects walking in adults with moderate hemophilia. About 24 participants will have their gait measured with motion capture and force platforms during a single visit. The study also collects cli…

This study looks at whether using an activity tracker with motivational feedback helps people become more active after knee replacement surgery compared to using a tracker without feedback. About 152 adults aged 40-85 scheduled for knee replacement will take part. The goal is to …

This study looked at how a mix of step-aerobic and resistance training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researc…

This study tested updated features of the ROSA Knee System, a robot used during knee replacement surgery. Forty adults having knee replacement took part. The goal was to check if the new features were safe and easy for surgeons to use, not to cure or treat the disease.

This completed study used Danish national health records to compare infection rates after total knee replacement in obese (BMI ≥30) versus non-obese patients. Researchers analyzed data from over 100,000 adults who had knee replacement for osteoarthritis between 2011 and 2021. The…

This study followed 225 people who had ACL reconstruction surgery to see how their knees were doing 10 years later. Researchers looked at X-rays and pain scores to find out which factors increase the risk of developing osteoarthritis. The goal is to better understand long-term ou…

This study looked at whether repairing the subscapularis tendon during reverse shoulder replacement surgery leads to better short-term outcomes. A total of 102 adults having primary reverse shoulder arthroplasty took part. Half had the tendon repaired, half did not. The goal was …

This study looked at whether special imaging techniques can predict how knee osteoarthritis will get worse over time. Researchers followed 167 people with knee osteoarthritis for 3 years, using MRI, X-rays, and bone texture analysis. The goal was to find patterns that could help …

This study looked at whether hip precautions—like not bending too far or crossing legs—are needed after hip replacement surgery. Over 1,100 patients were randomly assigned to follow precautions or not for six weeks. Researchers tracked dislocations, return to daily activities, an…

This study looked at how common joint pain and swelling are in 100 nursing home residents aged 65 and older, both with and without dementia. Researchers performed a physical exam and used simple pain questions or a special checklist for those with severe dementia. The goal was to…

This study tested a mixed reality system called HOLOBLUEPRINT that helps surgeons see 3D plans during shoulder replacement surgery. 44 adults having shoulder surgery used the tool. Researchers checked if the implant was placed accurately by comparing CT scans before and after sur…