University Of Pittsburgh

This study tests a new program where schools, families, and doctors work together to help children manage type 1 diabetes. About 30 kids will take part to see if the program is practical and well-liked. The goal is to improve daily diabetes care at school.

This study tests which ACL surgery method works best for young, active people at high risk of re-injury. About 1,200 participants aged 14-25 will receive either a bone-patellar-tendon-bone or quadriceps tendon graft, with or without an extra stabilizing procedure. The goal is to …

This study looks at using radiofrequency ablation (RFA), a heat-based treatment, to control lung tumors in people who cannot have surgery. It involves 72 adults with early-stage lung cancer or tumors that have spread to the lungs. The goal is to see if RFA can help control the tu…

This study looks at whether allowing pregnant women with diabetes to have slightly higher blood sugar levels during labor can reduce the chance of their newborns having dangerously low blood sugar. Researchers will compare a more relaxed blood sugar target to the usual strict con…

This pilot study tests whether group telemedicine visits can help young adults (ages 18-26) with type 1 diabetes learn and practice self-management skills. Participants attend up to 4 virtual sessions and are followed for 6 months. The goal is to improve engagement in diabetes ed…

This study aimed to see if romosozumab (Evenity) could improve bone density and muscle mass in postmenopausal women with osteoporosis who need spine surgery. Participants would have received either romosozumab or alendronate before surgery. However, the trial was withdrawn before…

This study tests whether giving time- and event-based cues (like alarms or visual reminders) helps people with schizophrenia or schizoaffective disorder remember to take their medication. 104 adults aged 18-60 with a schizophrenia diagnosis are taking part. The goal is to see if …

This study tests a program called Forging Hopeful Futures that teaches teens aged 13-19 about racial, gender, and economic fairness to help them avoid violence. About 720 teens from participating neighborhoods or schools will take part. Researchers will check if the program reduc…

This study tests whether a smartphone mindfulness app can help stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will either use the app for four weeks or continue their normal routine. Researchers will measure stress, blood pressure, and…

This study tests whether a short computer-based cognitive training can enhance and extend the rapid antidepressant effects of ketamine or esketamine. Researchers will enroll 600 adults aged 18-80 with treatment-resistant depression who are already receiving ketamine as part of th…

This study tests a mobile cognitive-behavioral therapy program called MAAT to help breast cancer survivors who have memory and concentration problems after chemotherapy. About 220 survivors who finished chemo 1-5 years ago will either use MAAT or receive supportive therapy. The g…

This study tests whether an enhanced telemedicine program is practical for adults with type 2 diabetes who use insulin and have other health issues. Participants will have 2-3 video visits over 6 months, with some getting extra support like pre-visit calls and education. The goal…

This study is testing a family-focused therapy for families who lost a parent to suicide at least a year ago. It includes 30 families with children aged 8-14 who are struggling with prolonged grief. The therapy is done online and aims to reduce grief symptoms in both parents and …

This study tests whether adding a computer-based cognitive training program can improve depression relief for people already receiving esketamine treatment. Researchers will enroll up to 40 adults aged 18-80 at the University of Pittsburgh. The goal is to see if this approach can…

This study tests a program called Nae Disha for Life to see if it can reduce suicide thoughts in young people aged 12-17 in rural India. About 272 students from 4 schools will take part. The program teaches resilience and coping skills to help ease suicidal thoughts and anxiety.

This study tests an electronic symptom management system called Nurse AMIE in 344 people with stage 3 or 4 cancer living in rural areas. The goal is to see if tracking symptoms digitally can improve survival and quality of life. Participants use the system to report symptoms, and…

This study looks at whether having surgery earlier or later, and starting rehab sooner or later, helps people with severe knee injuries recover faster. It includes 690 military personnel and civilians aged 16 to 55 with injuries to two or more knee ligaments. Participants are ran…

This study follows 180 children with overweight or obesity to see how their thinking skills, especially memory and control, relate to their eating behaviors and weight changes over time. Researchers will use brain tasks and interviews to understand these links. The goal is to fin…

This study looks at whether the inner shape (concave or convex) of a full-arch dental implant bridge affects bone loss around the implants. Researchers will measure bone levels and plaque buildup in 50 adults who have had these bridges for at least a year. The goal is to find out…

This study looks at whether a mindfulness program can improve attention and brain connectivity in 11-14 year olds who have a family history of mood disorders and high mood swings. About 224 teens will be randomly assigned to mindfulness or a health education class. The goal is to…

This study tests whether a mobile health app can help parents of children aged 5-8 with disruptive behaviors. 324 parents will be randomly assigned to use the app alone, with a coach, or a control version. The goal is to see which approach improves parenting skills and child beha…

This study looks at two different strategies to get more veterans tested for colon and liver cancer: directly contacting people who need screening, or helping doctors fix delays. Researchers will compare how well each method works across many VA sites. The goal is to find the mos…

This study looks at how the overall environment and attitudes in schools (called 'school ethos') affect mental health programs for young people. Researchers will interview students, teachers, parents, and school staff in Chennai, India to find out what helps or hinders these prog…

This study looks at whether a pharmacist's review that includes a person's genetic test results can lead to better medication outcomes and lower healthcare costs. About 600 employees from Pitt/UPMC who already had genetic testing will take part. Half will get a medication review …

This study follows 2,000 adults aged 45-75 in Pennsylvania to better understand why some groups have higher heart disease risk. Researchers will test a community-based program to help high-risk participants lower their risk. The goal is to improve prevention and reduce heart-rela…

This study looks at how gum inflammation around dental implants heals after being treated with or without a smoothing procedure called implantoplasty. Researchers will track 30 adults with previously treated implants to measure gum bleeding, plaque, and immune markers. The goal i…

This study follows 164 adults with dental implants for 15 months to see if bleeding when the dentist probes the gums can predict bone loss around the implant. Participants attend check-ups every 3 months, where the dentist measures bleeding and takes X-rays to track bone levels. …

This study works with 24,000 families in Allegheny County to test programs that help young children from birth to school age develop language, behavior, and thinking skills. It focuses on supporting parents and preventing problems, especially in low-income families. The goal is t…

This study tests a program called ALIGN, designed to help adults with spina bifida better manage their health tasks like coordinating doctors and handling insurance. The program includes six virtual group sessions and one individual session. Researchers will check if the program …

This study follows 2,500 people with GERD to see how well medication and surgery work over time. Researchers track quality of life, symptom relief, and patient satisfaction. The goal is to help doctors and patients choose the best treatment.

This study aimed to measure antibiotic levels in the knee joint fluid of people being treated for an infected knee replacement. Researchers planned to use mass spectrometry to track how antibiotics elute from a spacer placed during surgery. The study was withdrawn before enrollin…