University Hospital Tuebingen

This study is testing a personalized peptide vaccine for children and young adults (up to age 30) with metastatic fusion-driven sarcomas (Ewing sarcoma, rhabdomyosarcoma, synovial sarcoma) who have completed standard treatment. The vaccine is custom-made for each patient based on…

This study tests a new booster vaccine called Prime-2-CoV_Beta, made from a harmless sheep virus, to see if it is safe and boosts immunity against COVID-19. About 96 healthy adults aged 18 to 55 who have already had COVID vaccines and infections will receive one booster dose. Res…

This early-stage trial tests a personalized peptide vaccine for people with a rare liver cancer called fibrolamellar hepatocellular carcinoma (FLC) or other tumors that share a specific genetic change (DNAJB1-PRKACA fusion). The vaccine is designed to train the body's immune cell…

This study tests a treatment called Lecigon® for people with Parkinson's disease. It is a gel given through a tube into the intestine that delivers a steady dose of medication. The goal is to see if this method reduces certain behavioral and emotional side effects better than sta…

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study tests a drug called tafasitamab in children aged 3 to 17 with a type of leukemia (B-cell ALL) that has come back or not responded to treatment. The goal is to see if the drug is safe and can delay or prevent the cancer from returning after a stem cell transplant. About…

This study tests whether robot-assisted groin lymph node removal causes fewer serious side effects than standard open surgery in 80 men with penile cancer. The goal is to reduce wound healing problems and other complications while still effectively controlling the cancer. Partici…

This study tests whether a non-invasive physical plasma treatment can clear HPV infections from the cervix. About 50 adults with HPV will receive the treatment, and researchers will check if the virus is gone afterward. The goal is to find a new way to prevent cervical cancer cau…

This study tests a precise type of radiation guided by MRI, given with standard chemotherapy, for people with distal rectal cancer. The goal is to destroy the tumor and avoid major surgery to remove the rectum. About 100 participants will be followed for two years to see if the t…

This study tests whether giving a higher dose of radiation along with a drug called bevacizumab can help people with a fast-growing brain tumor (glioblastoma) live longer. About 146 adults aged 18 to 70 with a specific type of glioblastoma will receive the treatment. The goal is …

This study tests whether a noninvasive magnetic stimulation, timed to the brain's natural rhythms, can help people recover arm and hand movement after a recent stroke. 144 participants who had a stroke 1-14 days ago and have arm weakness will receive either timed stimulation, unt…

This study compares quality of life in adults with Crohn's disease during a flare when treated with either standard care or an adapted diet plus liquid nutrition. About 52 participants will be assigned to one of two groups. The goal is to see if the diet approach leads to better …

This study tests a mindfulness program called 'Healthy under Stress' to see if it can lower stress levels in adults. Researchers will measure stress using a questionnaire before and after the program. The goal is to help people better cope with daily pressures.

This study tests an app designed to help families of premature babies track their mental and physical health after leaving the hospital. The goal is to identify problems early and offer personalized support. About 120 families with babies born between 28 and 34 weeks will partici…

This study follows people with congenital heart disease who already received a Melody valve as part of an earlier registry. Researchers will track long-term outcomes like death, need for repeat surgery, or valve infection. The goal is to understand how well the valve works over t…

This study follows 300 people with a rare genetic movement disorder called SCA27B, along with some family members and healthy volunteers, for up to 2 years. Researchers will use exams, digital devices, and blood tests to measure how the disease changes over time. The goal is to f…

This study looks at women with early-stage, hormone-positive breast cancer to see if the phase of their menstrual cycle changes a key growth marker called Ki67. Researchers will also check if adding a genetic test (PAM50) helps doctors choose better treatments. About 504 women wi…

This study aims to improve care for breast cancer patients by collecting health data and blood samples from 13,500 participants. Researchers will analyze up to 500,000 biomarkers to better understand how tumors change and which treatments work best. The goal is to make cancer car…

This study looks at how stress and inflammation affect the brains of women with major depressive disorder (MDD) or premenstrual dysphoric disorder (PMDD). Researchers will compare brain scans, stress responses, and immune markers in 75 naturally cycling women. The goal is to bett…

This study aims to train an artificial intelligence (AI) model to automatically detect surgical smoke during laparoscopic surgery. Researchers will collect video footage from 30 women undergoing laparoscopic procedures that use high-frequency surgery, which produces smoke. The AI…

This study looks back at genetic test results from about 12,000 people with rare diseases or family cancer syndromes. Researchers want to see how often newer DNA sequencing methods find a diagnosis compared to older tests. No new treatments are given; the goal is to learn which t…

This study watches about 185 people with anorexia or bulimia during a weight rehabilitation program. Researchers track stomach symptoms weekly and see if a flexitarian, vegetarian, or vegan diet makes a difference. The goal is to learn which diet might ease discomfort, not to tes…

This study is testing whether different types of surgeries create unique electrical patterns, like a digital fingerprint. Researchers will collect data from 160 adults undergoing specific procedures and see if a computer can correctly identify the surgery type just from the elect…

This study looks at why some patients experience heart injury after non-cardiac surgery. Researchers will track 3000 adults aged 40-80 with heart risks to see how anesthesia and surgery factors contribute. The goal is to find ways to better monitor and protect high-risk patients …

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecologic cancers (cervical, endometrial, ovarian, or vulvar). Researchers will track CRP levels in 120 women receiving immunotherapy plus chemo…

This study is for women with triple-negative breast cancer, either early-stage or advanced, who are receiving immunotherapy. Researchers want to see if changes in a simple blood marker called CRP can predict how well the treatment works. The goal is to find a way to personalize t…

This study creates a database to track leptomeningeal disease, a rare condition where cancer spreads to the membranes around the brain and spinal cord. Researchers will collect information from 50 adults in Germany about treatments, side effects, and survival. The goal is to bett…