The Fourth Affiliated Hospital Of Zhejiang University School Of Medicine

This trial tests whether a cold knife hysteroscopy technique (Yiwu procedure) can remove multiple endometrial polyps as effectively as standard electrocision, but with less damage to the uterine lining. About 850 women aged 20 to 48 with multiple polyps will be randomly assigned …

This study tests whether an oral medication that removes lead from the body can slow kidney function decline in people with type 2 diabetes and high lead levels. Participants take dimercaptosuccinic acid (DMSA) capsules for up to 3 months, then are followed for 12 months. The goa…

This study tests whether a drug that removes lead from the blood can slow the worsening of kidney function in people with type 2 diabetes who also have higher-than-normal lead levels. Participants receive intravenous infusions of calcium disodium edetate, and their kidney functio…

This study develops and tests a standardized oral care protocol for stroke patients who have a breathing tube (orotracheal intubation). The goal is to see if this special mouth care plan can lower the risk of ventilator-associated pneumonia compared to usual care. The trial inclu…

This study tests whether a smartphone app, based on proven talk therapies, can help adolescents aged 12–25 who engage in non-suicidal self-injury (NSSI). Participants use the app for 8 weeks, completing short modules on emotion regulation, distress tolerance, and mindfulness, plu…

This phase 2 trial tests whether combining SKB264 (a chemotherapy) with anlotinib (a targeted therapy) can shrink tumors and control disease in people with advanced non-small cell lung cancer that has spread to the liver and stopped responding to standard EGFR-targeted drugs. Abo…

This phase 4 trial will test whether adding alogliptin to a standard two-drug regimen (pioglitazone and metformin) improves blood sugar control and liver health in 80 adults with type 2 diabetes and fatty liver disease. Participants must not have used diabetes medications in the …

This study will test whether taking liraglutide together with orlistat helps overweight or obese adults lose more weight than liraglutide alone. About 120 participants will be followed for 24 weeks. The goal is to see which approach works better in real-world conditions.

This phase 2 trial is testing a combination of four drugs—irinotecan liposome, capecitabine, bevacizumab, and camrelizumab—as a second or later treatment for people with metastatic colorectal cancer. The study will enroll 68 participants and measure how long the disease stays und…

This study looks at whether lying on the side at different angles can improve lung function in people with acute respiratory distress syndrome (ARDS), a serious lung condition. About 140 adult patients will be randomly placed in either the standard face-down position or a side-ly…

This study tests whether a herbal medicine called Danhong injection can help protect the heart in people with sepsis, a life-threatening infection. Researchers will give 140 patients either the injection or a placebo for 7 days and check heart function and survival rates. The goa…

This study tests a smartphone-based rehab program for young and middle-aged people (18-60) who had a heart attack. The program uses an app to guide exercise, diet, medication, and stress management, with support from a team of heart doctors, nurses, nutritionists, and psychologis…

This study tests Shenkangling, a traditional Chinese herbal tonic, in 100 adults who experience kidney injury during surgery. The goal is to see if it helps kidneys recover and is safe. Participants take the herb twice daily, and researchers measure urine and blood markers of kid…

This trial is testing whether using a genetic test to choose antidepressants leads to better outcomes for people with major depressive disorder. Half of the 220 participants will have their treatment guided by a cheek swab that analyzes genes affecting drug metabolism, while the …

This trial tests whether adding a traditional Chinese herbal decoction, Bushen Huoxue Simiao Formula, to standard care can ease urinary symptoms and improve quality of life for adults recovering from upper urinary tract stone surgery. Participants, aged 18 to 80, will receive eit…

This study tests whether having a clinical pharmacist guide pain management before, during, and after orthopedic surgery can reduce moderate-to-severe pain. About 600 adults scheduled for major orthopedic procedures (like hip or knee replacement) will be randomly assigned to eith…

This study looks at whether adding a bacterial lysate (OM-85) to standard antihistamines can better control chronic spontaneous urticaria (CSU), also known as chronic hives. Researchers will observe 132 adults who have not responded well to antihistamines alone. The main goal is …

This study tests whether a smartphone app can improve recovery for 60 adults after knee ligament surgery. The app provides exercise videos, lets patients upload their own videos for feedback, and offers online chats with nurses and therapists. The goal is to help patients exercis…

This study tests whether a chatbot on the Doubao app can reduce depression in people who have had a stroke. Researchers will enroll 240 participants and use the chatbot to provide positive psychological counseling. The main goal is to see if depression scores improve, with qualit…

This study tests a nursing program based on the ABC-X model for 117 adults aged 30-65 getting their first total knee replacement. The program helps patients and families handle stress, find support, and think more positively. Researchers will measure mental strength, self-care, e…

This study tests whether a structured cognitive behavioural therapy (CBT) program can reduce social media addiction by targeting 'rest shame'—the guilt people feel when taking breaks. Researchers will randomly assign 120 university students aged 18-25 to receive the CBT intervent…

This study looks at why some people have trouble sleeping on their first night after lung surgery. Researchers will collect information before, during, and after surgery to build a model that predicts who is most likely to have poor sleep. They will also examine how hospital rout…

This study explores whether a full English course built on the DeepSeek artificial intelligence platform can improve orthopedic nurses' professional English skills. Twenty nurses will take an 11-week blended online and offline course covering topics like trauma nursing, joint rep…

This study aims to create an AI system that combines Traditional Chinese Medicine (TCM) body type data with modern technology to give personalized health advice. Researchers will enroll 195 adults who have all three conditions: high blood pressure, high blood sugar, and high chol…

This study looks at how sensory training changes brain connections in people with chronic low back pain. Researchers will use brain scans to track these changes and see if they relate to pain relief. The goal is to better understand how the brain adapts, not to test a new treatme…

This study tests whether a traditional Chinese therapy called umbilical moxibustion (applying heat near the belly button) can help people with irritable bowel syndrome (IBS). Researchers will compare gut bacteria and blood chemicals between 60 patients who receive the therapy and…

This study will create and test a WeChat mini-program that provides health education to people with interstitial lung disease. The program covers disease knowledge, medication, diet, and rehabilitation, and allows patients to check test results and consult with doctors. Researche…