National Institute Of Environmental Health Sciences (niehs)

This study tests an oral drug called H01 (hymecromone) in 37 adults with interstitial lung disease, a condition that causes lung scarring and often leads to death within 3-5 years. Participants take the drug twice daily for 12 weeks. The goal is to see if H01 can lower a marker o…

This study tests whether omega-3 fatty acid supplements from fish oil can reduce disease activity in adults with dermatomyositis, a rare autoimmune condition causing muscle weakness and skin rashes. About 300 participants will take either omega-3 capsules or a placebo for 6 month…

This study aims to learn more about myositis, a group of diseases that cause muscle inflammation and damage. Researchers will study up to 1,200 children and adults with or without myositis to understand its causes, immune system changes, and related health problems. Participants …

This study looks at how things in your environment—like pollution, chemicals, food, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like infertility, early or late puberty, or hormone imbalances…

This study aims to understand how environmental factors like pollution, diet, and stress contribute to human diseases. Researchers will collect blood, urine, hair, and other samples from 2,000 healthy adults aged 18 and older. Participants may also complete surveys and provide sa…

This study aims to understand how the COVID-19 pandemic has affected the mental, physical, and social well-being of minority women and their families in North Carolina. Researchers will survey 700 healthy women aged 18 and older, and may collect blood, urine, saliva, toenail, dus…

This study follows healthy girls ages 8-14 and those at risk for PCOS to learn how their menstrual cycles become regular in the first two years after their first period. Researchers will track hormones and cycle patterns through at-home urine tests and clinic visits every six mon…

This study looks at whether overweight girls start puberty earlier than normal-weight girls. Researchers will use breast and pelvic ultrasounds, blood and urine tests, and X-rays to measure body fat and bone maturity. The goal is to understand if early breast development in overw…

This study aims to find genetic causes of inherited reproductive disorders, such as early or delayed puberty and infertility. Researchers will collect blood samples, medical histories, and smell tests from 850 participants with these conditions. No treatment is offered; the goal …

This study looks at how a person's genes and their environment (like pollution, diet, and lifestyle) work together to cause common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires and genetic data from 25,000 adults to build a…

This study looks at whether certain environmental exposures—like infections, stress, or sun exposure—are more common in people with anti-synthetase syndrome (a type of myositis with lung involvement) compared to other myositis patients and healthy volunteers. Researchers will col…

This study looks at how white blood cells from healthy adults respond to different signals in a lab. The goal is to understand how these cells sense threats and may cause inflammation. Participants donate blood up to six times a year, which is used to test cell reactions and meas…

This study follows 400 nonsmoking adults aged 18–60 with moderate-to-severe asthma for up to 5 years. Researchers collect blood, urine, stool, dust, saliva, and lung samples at regular visits to see how bacteria and other environmental factors affect asthma symptoms and flare-ups…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…