National Institute Of Environmental Health Sciences (niehs)

This completed Phase 2 trial looked at whether vitamin D supplements affect hormones linked to healthy menstrual cycles. Nearly 1,000 women aged 19-40 with natural cycles took either high-dose vitamin D (50,000 IU/week) or a placebo for about 3 months. Researchers measured hormon…

This completed study looked at how genetic differences might change the way immune cells in the lungs respond to environmental triggers like dust and germs. Researchers collected blood and lung samples from 20 healthy adults to compare cell function between people with different …

This study collects biological and environmental samples—like blood, urine, saliva, and household dust—from over 5,000 healthy adults. The goal is to create a biobank that researchers can use to develop and validate new lab tests for environmental health studies. Participants pro…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study looked at people with low or no GnRH, a hormone that controls puberty and fertility. Researchers studied 111 adults and teens to understand how GnRH problems affect the body. The goal was to find new hormone patterns and genetic causes, not to test a treatment.

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study examined whether a chemical called TGF-Beta, which is more common in the lungs of people with asthma, makes them more vulnerable to respiratory syncytial virus (RSV). Researchers collected lung cells from 113 healthy adults and mild asthmatics using a bronchoscopy. The…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This study looked at how certain gene variations affect the health of blood vessels in 178 healthy adults. Participants had an ultrasound and a short-acting medication to measure blood flow. The goal was to learn more about genetic risks for heart disease, not to provide treatmen…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study looked at how small differences in the COX-2 gene affect the balance of immune cells that play a role in allergies and asthma. Researchers analyzed blood and urine samples from 117 adults who were part of a larger genetic registry. No treatments were given; the goal wa…

This study looked at how diet and exercise changes affect hormones and menstrual cycles in healthy women aged 18-28. Participants followed special diets and exercise programs while researchers measured hormone levels. The goal was to better understand a condition called functiona…

This study looked at why Black professionals and managers often have shorter, lower-quality sleep than their white coworkers. Researchers held focus groups with 263 Black and white adults who work full-time. They asked about work, sleep habits, and health to find patterns that mi…

This study looked at how certain genes in blood cells respond to environmental exposures in 178 healthy volunteers aged 18 to 45. Researchers measured gene activity to better understand links to inflammation, cancer, and other diseases. The goal was to gather knowledge, not to pr…

This study aimed to improve how scientists measure people's contact with chemicals in household and personal care products. Eleven healthy women aged 35-74 who used at least 15 products daily took part. Researchers compared surveys, home air samplers, dust samples, and urine test…

This study followed 132 healthy smokers and non-smokers aged 30-55 to see how smoking history affects immune cells and COVID-19 risk. Participants provided blood, saliva, and nasal swab samples over up to six monthly visits. The goal is to understand why smokers may have more sev…

This study followed 643 healthy adults in central North Carolina for one year to see how many developed antibodies to the COVID-19 virus. Participants had blood drawn five times and completed weekly symptom surveys. The goal was to better understand exposure rates and immune resp…