Nanjing First Hospital, Nanjing Medical University

This study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …

This study tests a procedure called pulmonary artery denervation (PADN) for people with heart failure whose heart pumps normally but is stiff. The procedure uses a catheter to burn nerves in the lung artery, which may help the heart work better. About 310 participants will either…

This study tests whether giving a low dose of esketamine or raising both legs before anesthesia can prevent blood pressure drops in elderly patients undergoing chest surgery. About 292 people aged 60-80 will take part. The goal is to find a simple way to keep blood pressure stabl…

This study will enroll 404 people with severe leakage in both the mitral and tricuspid heart valves. Participants will be randomly assigned to have either both valves repaired at once using a catheter-based device, or only the mitral valve repaired. The goal is to see which appro…

This study tests whether adding a traditional Chinese medicine granule (Huazhi Rougan) to standard antibiotics can better treat both H. pylori infection and metabolic-associated fatty liver disease (MASH). About 286 adults with both conditions will receive either the herbal granu…

This study tests whether a traditional Chinese medicine herbal formula, Jianpi Lishi Jiedu Granules, can prevent colorectal adenomas (precancerous polyps) from returning after they are removed during a colonoscopy. About 376 adults who recently had such polyps removed will take e…

This study tests a new method for numbing the throat before inserting a breathing tube while the patient is awake. It compares two ultrasound-guided nerve block techniques in 94 adults with difficult airways. The goal is to see if the newer thyroid cartilage approach works as wel…

This study investigates whether a molecule called PK2 in the blood is linked to thinking and memory problems that some older adults experience after surgery. Researchers will measure PK2 levels in 40 patients aged 65 to 80 before and after hip replacement surgery, and compare tho…

This study looks at 1,300 people with moderate-risk pulmonary embolism (blood clots in the lungs) to compare three treatments: blood thinners, clot-busting drugs, and mechanical clot removal. Researchers will track deaths, heart recovery, bleeding risks, and quality of life over …

This study tests whether a new, non-invasive AI-assisted simulation training helps anesthesia residents improve their ultrasound-guided needle skills. Thirty residents will be randomly assigned to either the new simulation training or standard teaching. The main goal is to see if…