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Can a drug and a leg lift prevent anesthesia danger in seniors?

NCT ID NCT07374458

Disease control Sponsor: Nanjing First Hospital, Nanjing Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a low dose of esketamine or raising both legs before anesthesia can prevent blood pressure drops in elderly patients undergoing chest surgery. About 292 people aged 60-80 will take part. The goal is to find a simple way to keep blood pressure stable and reduce risks like heart or kidney problems.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Esketamine
What this could lead to
If it works, this could offer a simple way to prevent dangerous blood pressure drops during anesthesia in older patients, reducing complications.
What could go wrong
This is an early-stage study with no phase, so results are uncertain. The approach may not work for all patients or could have side effects like dizziness or nightmares.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 292 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 60-80 years old * American Society of Anesthesiologists (ASA) physical status classification Ⅰ-Ⅲ * Scheduled for elective thoracoscopic surgery under general anesthesia * Informed consent: All patients or their family members voluntarily agree to participate in the study and sign the informed consent form Exclusion Criteria: * Allergy to the drugs used in this study * Severe cardio-cerebro-pulmonary diseases (including myocardial infarction, heart failure, cerebral hemorrhage, stroke, respiratory failure) * Severe hepatic or renal diseases (Child-Pugh class C, or requiring renal replacement therapy) * Severe neurological diseases (including Parkinson's disease, Alzheimer's disease) * History of poorly controlled hypertension, or systolic blood pressure \> 180 mmHg or mean arterial pressure (MAP) \< 70 mmHg before anesthesia induction * Increased intracranial pressure, glaucoma, penetrating ocular trauma, or moderate to severe pulmonary arterial hypertension * Spinal diseases (deformity or trauma), history of spinal surgery, abnormal skin sensation of the chest and back, infection at the puncture site, or abnormal coagulation function * Abdominal hypertension or lower extremity deep vein thrombosis * Emergency surgery * Body mass index (BMI) ≥ 35 kg/m²

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-induction hypotension

How to take part

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  1. The official record

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